Protein detail

PGFRA

Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)

Protein symbol
PGFRA
UniProt ID
P16234
EVMP score
0.50
Frequency
3
Transmembrane count
1
Protein classification
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins
Basic Information
Protein Names
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Protein Class
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins
Protein Function
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • CD markers
  • RAS pathway related proteins
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
  • FDA approved drug targets:Biotech drugs
Transmembrane
529..549; Helical
Transmembrane Count
1
Ensembl
ENSG00000134853
Entrez Gene Symbol
PDGFRA
Gene Synonym
CD140aGAS9PDGFR2
Gene Description
Platelet derived growth factor receptor alpha
Chromosome
4
Position
54229280-54298245
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecifictestisCell SpecificRetinal pigment epithelial cellsSingle-Nuclei Brain SpecificMGE interneuronSecretome LocationSecreted in other tissuesSecretome FunctionReceptor
Function & Pathway
Protein Function
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • CD markers
  • RAS pathway related proteins
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
  • FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
  • M117 Pid cone pathway
  • M204 Pid rhodopsin pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

5 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
PDGFRAPTPRGP23470Y754dephosphorylationSIGNORSIGNOR:25624455
PDGFRAPTPRGP23470Y742dephosphorylationSIGNORSIGNOR:25624455
PDGFRAPTPRGP23470Y754phosphorylationSIGNOR_ProtMapperProtMapperProtMapper:25624455
PDGFRAPTPRGP23470Y742phosphorylationSIGNOR_ProtMapperProtMapperProtMapper:25624455
PDGFRAPDGFRBP09619Y754phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper

Ligand-Receptor Signaling

70 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorCellPhoneDBNoYesNoYesNo
receptorreceptorGO_IntercellNoYesNoYesNo
receptorreceptorHPMRNoYesNoYesNo
receptorreceptorICELLNETNoYesNoYesNo
receptorreceptorCellChatDBNoYesNoYesNo
receptorreceptorCellTalkDBNoYesNoYesNo
receptorreceptorSurfaceomeNoYesNoYesNo
receptorreceptorRamilowski2015NoYesNoYesNo
receptorreceptorKirouac2010NoYesNoYesNo
receptorreceptorLRdbNoYesNoYesNo
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Regulatory Interaction Network

12 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
PGFRBP09619PGFRAP16234YesYesNoWangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperHPRDHINTSignaLink3BioGRIDIntActSPIKE_LCLit-BM-17PhosphoSitePhosphoSite_ProtMapperPhosphoSite:7523122SignaLink3:7523122IntAct:11331882BioGRID:2542288HPRD:1847074Lit-BM-17:11331882HPRD:2161888SignaLink3:21071413SignaLink3:2542288Lit-BM-17:2542288HINT:11331882HPRD:7523122Lit-BM-17:7523122SignaLink3:23331499SPIKE_LC:16189514HPRD:2542288HINT:33961781HINT:2542288
CBLP22681PGFRAP16234YesYesYesSIGNORHPRDHINTSignaLink3ACSNWangSignaLink3:18988627SIGNOR:10347229ACSN:10514377ACSN:17635922HINT:30057274SignaLink3:23331499SignaLink3:9234717HPRD:9234717HINT:9234717
CAV1Q03135PGFRAP16234YesYesNoHPRDSPIKE_LCSignaLink3SignaLink3:18988627SignaLink3:10066366HPRD:10066366SignaLink3:23331499SPIKE_LC:16189514
PDGFCQ9NRA1PGFRAP16234YesYesNoiTALKICELLNETHINTSignaLink3DIPHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDIntActRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdbHPRD:11342471connectomeDB2020:11297552connectomeDB2020:10806482Baccin2019:11342471Cellinker:28267575ICELLNET:9739761LRdb:11342471HPRD:10806482SignaLink3:10806482HINT:11297552HPMR:15207811CellChatDB:15207812DIP:20534510IntAct:20534510IntAct:11297552LRdb:10806482SignaLink3:18988627Cellinker:15207812HPMR:10806482SignaLink3:23331499connectomeDB2020:11342471SignaLink3:11297552Baccin2019:10806482DIP:11297552Baccin2019:11297552SignaLink3:21071413IntAct:10806482LRdb:11297552ICELLNET:15207811HINT:20534510SignaLink3:11342471HINT:10806482CellTalkDB:10806482HPRD:11297552
PDGFAP04085PGFRAP16234YesYesNoiTALKKEGG-MEDICUSICELLNETSIGNORHINTSignaLink3UniProt_LRdbLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdbSignaLink3:11803579Cellinker:28267575ICELLNET:9739761HINT:11297552Lit-BM-17:7679113CellTalkDB:15207811IntAct:25241761Lit-BM-17:15767546Lit-BM-17:2544881CellChatDB:15207812SIGNOR:11803579Baccin2019:152078112544881Lit-BM-17:11297552HPRD:2544881connectomeDB2020:2544881Cellinker:15207812SignaLink3:23331499SignaLink3:21071413HINT:15767546HINT:7679113SignaLink3:2544881Lit-BM-17:25241761HINT:2544881LRdb:15207811ICELLNET:15207811connectomeDB2020:15207811IntAct:7679113LRdb:25
PDGFBP01127PGFRAP16234YesYesNoiTALKKirouac2010KEGG-MEDICUSICELLNETSIGNORHINTSignaLink3UniProt_LRdbLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDCui2007IntActDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSignaLink3:11803579Cellinker:28267575ICELLNET:9739761SIGNOR:11331882HINT:11297552Lit-BM-17:7679113CellTalkDB:15207811Lit-BM-17:15767546Lit-BM-17:9677323Lit-BM-17:2544881CellChatDB:15207812SignaLink3:18988627Lit-BM-17:11297552HPRD:2544881connectomeDB2020:2544881Cellinker:15207812SignaLink3:23331499Lit-BM-17:10806482SignaLink3:21071413HINT:15767546HINT:7679113IntAct:10806482SignaLink3:2544881HINT:9677323HINT:2544881LRdb:15207811ICELLNET:15207811connectomeDB2020:15207811HINT:10806482IntAct:7679113LRdb:25SPIKE_LC:16189514
PGFRAP16234PLCG1P19174YesYesNoKEGG-MEDICUSNCI-PID_ProtMapperPhosphoPointSIGNORProtMapperHPRDCui2007HINTKEAPhosphoSite_KEASignaLink3WangLit-BM-17Lit-BM-17:7535778SIGNOR:7535778KEA:16126727KEA:16153436KEA:8885868HINT:7535778KEA:17081983HINT:7682895KEA:7682059KEA:12601080KEA:15144186ProtMapper:7535778KEA:8657103KEA:1689310KEA:15592455SignaLink3:23331499HPRD:7535778Lit-BM-17:25241761KEA:1708307SignaLink3:7535778KEA:16038803
PGFRAP16234CRKP46108YesYesNoWangPhosphoPointSIGNORELMHINTHPRDSignaLink3IntActSPIKE_LCLit-BM-17Lit-BM-17:10733900ELM:27686861Lit-BM-17:9546424Lit-BM-17:25241761IntAct:25241761SignaLink3:9546424HPRD:9546424IntAct:9546424SIGNOR:19426560SIGNOR:10733900IntAct:10733900SPIKE_LC:16713569HPRD:10733900SignaLink3:23331499HINT:10733900HINT:9546424SignaLink3:10733900ELM:10733900
PTPRGP23470PGFRAP16234YesYesNoSIGNOR_ProtMapperSIGNORProtMapperSIGNOR:25624455ProtMapper:25624455
PGFRAP16234FAK1Q05397YesYesNoiPTMnetSIGNORProtMapperSIGNOR_ProtMapperWangSIGNOR:20802513ProtMapper:20802513
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Protein Complex Composition

5 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
PDGF receptor alpha - PDGF-AA complexPDGFAPDGFRAP04085P162342:2ComplexPortalintact:EBI-9080360PDB:3mjk112975521475529215207811
PDGF receptor alpha - PDGF-AB complexPDGFAPDGFBPDGFRAP01127P04085P162341:1:1ComplexPortalintact:EBI-90837701475529215207811
PDGF receptor alpha - PDGF-BB complexPDGFBPDGFRAP01127P162341:1ComplexPortalintact:EBI-9083388PDB:1pdg1475529215207811
PDGFRA-SHP-2 complexPDGF stimulatedPDGFRAPTPN11P16234Q061241:1CompleatCORUMCompleat:HC1066CORUM:31838943348
SNX complex (SNX1SNX1aSNX2SNX4PDGFRA)PDGFRASNX1SNX2SNX4O60749O95219P16234Q135961:1:1:1CompleatCORUMCORUM:1096Compleat:HC29909819414

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Protein Organic Solvent PrecipitationMass spectrometry132384937
Sequence, Structure & Domains

Sequences

Length
1,089
Mass
122,670
Sequence
MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P16234-1; Sequence=Displayed; Name=2; IsoId=P16234-2; Sequence=VSP_007833, VSP_007834; Name=3; IsoId=P16234-3; Sequence=VSP_042015, VSP_042016
Alternative Sequence
210..218; ATSELDLEM -> GTCIISFLL (in isoform 2); 219..1089; Missing (in isoform 2); 720..743; YVILSFENNGDYMDMKQADTTQYV -> SGQGCLSSGTLQELSVDLQARGPC (in isoform 3); 744..1089; Missing (in isoform 3)

3D Structural Models

Turn
62..65; 174..176; 777..782; 828..830
Helix
92..94; 103..105; 252..254; 577..579; 584..586; 590..592; 635..651; 682..688; 690..692; 769..774; 792..811; 821..823; 838..840; 843..845; 859..861; 864..869; 874..889; 903..910; 923..932; 937..939; 943..953; 956..971
Beta Strand
29..32; 35..38; 41..43; 46..53; 55..58; 67..69; 70..72; 80..86; 96..102; 107..111; 114..120; 124..128; 133..141; 144..148; 152..156; 159..167; 171..173; 177..181; 184..192; 197..199; 203..208; 216..219; 224..226; 231..237; 239..241; 246..248; 258..264; 266..268; 270..279; 286..292; 301..306; 308..310; 560..562; 567..570; 572..574; 593..601; 603..614; 616..618; 620..629; 660..664; 666..669; 671..675; 678..681; 824..827; 831..834; 849..851; 853..857
3D Structure
Electron microscopy (2); X-ray crystallography (13)

Domain & Motif Annotations

Compositional Bias
1041..1059; Polar residues; 1065..1089; Acidic residues
Domain (FT)
24..113; Ig-like C2-type 1; 117..201; Ig-like C2-type 2; 202..306; Ig-like C2-type 3; 319..410; Ig-like C2-type 4; 414..517; Ig-like C2-type 5; 593..954; Protein kinase
Region
1018..1089; Disordered
Protein Families
  • Protein kinase superfamily
  • Tyr protein kinase family
  • CSF-1/PDGF receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Related Diseases
Acute myeloid leukaemiaBCR-ABL1-negative chronic myeloid leukaemiaBrain cancerBreast cancerColon cancerColorectal cancerGastrointestinal stromal tumourGram-positive bacterial infectionKaposi sarcomaLung cancerMalignant digestive organ neoplasmMastocytosisMultiple myelomaMyelodysplastic syndromePancreatic cancerProstate cancerSolid tumour/cancerStomach cancerThrombocytopenia
Biomarker
Phase 2; Patented; Approved; Investigative; Phase 1; Phase 3
Drug Targets
FDA approved drug targets
Drugs
NILOTINIBFORETINIBNULLORANTINIBAVAPRITINIBSUNITINIBDOVITINIBAXITINIBCEDIRANIBCYC-116RIPRETINIBVATALANIBAST-487VANDETANIBNINTEDANIB ESYLATEXL820TANDUTINIBSORAFENIBIMATINIBDASATINIB ANHYDROUSBECAPLERMINTOVETUMABPAZOPANIBZM447439LINIFANIBBARASERTIB-HQPAX-82RAMUCIRUMABMIDOSTAURINTELATINIBPONATINIBFAMITINIBMOTESANIBAMUVATINIBBARASERTIBENMD-981693XL-820NVP-TAE684MEPOLIZUMABVARGATEFXL-999QUIZARTINIBILORASERTIBPP2CHEMBL:CHEMBL1997335CRENOLANIBMASITINIBPD-0166285OLARATUMABCP-547632REGORAFENIBRG-1530ENMD-2076TAMATINIBPEGPLERANIB SODIUMROMIPLOSTIMLENVATINIBSU-014813TAK-593RABEPRAZOLESERALUTINIBCENISERTIB
Antibody
HPA004947CAB018143
Interaction Protein
ENSG00000100311ENSG00000145431ENSG00000146648ENSG00000197461
Interaction Count
4
Interaction Dataset
intact_biogrid