Protein detail
PGFRA
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Protein symbol PGFRA | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins |
Basic Information
Protein Names
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Protein Class
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- CD markers
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Transmembrane
529..549; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD140aGAS9PDGFR2
Gene Description
Platelet derived growth factor receptor alpha
Chromosome
4
Position
54229280-54298245
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecifictestisCell SpecificRetinal pigment epithelial cellsSingle-Nuclei Brain SpecificMGE interneuronSecretome LocationSecreted in other tissuesSecretome FunctionReceptor
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- CD markers
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Cellular Component
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005789 endoplasmic reticulum membrane
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0005902 microvillus
- GO:0005929 cilium
- GO:0009897 external side of plasma membrane
- GO:0016020 membrane
- GO:0030054 cell junction
- GO:0032991 protein-containing complex
- GO:0043235 receptor complex
Molecular Function
- GO:0004672 protein kinase activity
- GO:0004714 transmembrane receptor protein tyrosine kinase activity
- GO:0005018 platelet-derived growth factor alpha-receptor activity
- GO:0005021 vascular endothelial growth factor receptor activity
- GO:0005161 platelet-derived growth factor receptor binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0038085 vascular endothelial growth factor binding
- GO:0042803 protein homodimerization activity
- GO:0044877 protein-containing complex binding
- GO:0048407 platelet-derived growth factor binding
- GO:0160185 phospholipase C activator activity
Biological Process
KEGG
- hsa01521 EGFR tyrosine kinase inhibitor resistance
- KEGG:hsa04010 MAPK signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04144 Endocytosis
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04540 Gap junction
- KEGG:hsa04630 JAK-STAT signaling pathway
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05206 MicroRNAs in cancer
- KEGG:hsa05214 Glioma
- KEGG:hsa05215 Prostate cancer
- KEGG:hsa05218 Melanoma
- KEGG:hsa05230 Central carbon metabolism in cancer
- KEGG:hsa05231 Choline metabolism in cancer
Reactome
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-186763 downstream signal transduction
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-199418 negative regulation of the pi3k akt network
- R-hsa-2219528 pi3k akt signaling in cancer
- R-hsa-186797 signaling by pdgf
- R-hsa-9673767 signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants
- R-hsa-9671555 signaling by pdgfr in disease
- R-hsa-9006934 signaling by receptor tyrosine kinases
Canonical Pathways
- M117 Pid cone pathway
- M204 Pid rhodopsin pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PDGFRA | PTPRG | P23470 | Y | 754 | dephosphorylation | SIGNOR | SIGNOR:25624455 |
| PDGFRA | PTPRG | P23470 | Y | 742 | dephosphorylation | SIGNOR | SIGNOR:25624455 |
| PDGFRA | PTPRG | P23470 | Y | 754 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:25624455 |
| PDGFRA | PTPRG | P23470 | Y | 742 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:25624455 |
| PDGFRA | PDGFRB | P09619 | Y | 754 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
70 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
| receptor | receptor | SignaLink_function | No | Yes | No | Yes | No |
| kinase | receptor | Almen2009 | No | Yes | No | Yes | No |
| pdgf | receptor | Almen2009 | No | Yes | No | Yes | No |
| growth_factor_receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| growth_factor | receptor | Baccin2019 | No | Yes | No | Yes | No |
| receptor_tyrosine_kinases_rtk | receptor | HPMR | No | Yes | No | Yes | No |
| vegf_pdgf | receptor | HPMR | No | Yes | No | Yes | No |
| kinase | receptor | Surfaceome | No | Yes | No | Yes | No |
| pdgfr | receptor | Surfaceome | No | Yes | No | Yes | No |
Regulatory Interaction Network
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PGFRA | P16234 | SRC | P12931 | Yes | Yes | No | WangSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperPhosphoSite_KEAKEASIGNOR_ProtMapperPhosphoSite_ProtMapper | KEA:14661060KEA:15489898KEA:17081983KEA:7578094KEA:9988270KEA:11278940KEA:11804588ProtMapper:25412774SIGNOR:15489898ProtMapper:15845350ProtMapper:15489898KEA:6273838 |
| PGFRA | P16234 | DAPLE | Q9P219 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:29487190 |
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Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| PDGF receptor alpha - PDGF-AA complex | PDGFAPDGFRA | P04085P16234 | 2:2 | ComplexPortal | intact:EBI-9080360PDB:3mjk | 112975521475529215207811 |
| PDGF receptor alpha - PDGF-AB complex | PDGFAPDGFBPDGFRA | P01127P04085P16234 | 1:1:1 | ComplexPortal | intact:EBI-9083770 | 1475529215207811 |
| PDGF receptor alpha - PDGF-BB complex | PDGFBPDGFRA | P01127P16234 | 1:1 | ComplexPortal | intact:EBI-9083388PDB:1pdg | 1475529215207811 |
| PDGFRA-SHP-2 complexPDGF stimulated | PDGFRAPTPN11 | P16234Q06124 | 1:1 | CompleatCORUM | Compleat:HC1066CORUM:3183 | 8943348 |
| SNX complex (SNX1SNX1aSNX2SNX4PDGFRA) | PDGFRASNX1SNX2SNX4 | O60749O95219P16234Q13596 | 1:1:1:1 | CompleatCORUM | CORUM:1096Compleat:HC2990 | 9819414 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,089
Mass
122,670
Sequence
MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P16234-1; Sequence=Displayed; Name=2; IsoId=P16234-2; Sequence=VSP_007833, VSP_007834; Name=3; IsoId=P16234-3; Sequence=VSP_042015, VSP_042016
Alternative Sequence
210..218; ATSELDLEM -> GTCIISFLL (in isoform 2); 219..1089; Missing (in isoform 2); 720..743; YVILSFENNGDYMDMKQADTTQYV -> SGQGCLSSGTLQELSVDLQARGPC (in isoform 3); 744..1089; Missing (in isoform 3)
3D Structural Models
Turn
62..65; 174..176; 777..782; 828..830
Helix
92..94; 103..105; 252..254; 577..579; 584..586; 590..592; 635..651; 682..688; 690..692; 769..774; 792..811; 821..823; 838..840; 843..845; 859..861; 864..869; 874..889; 903..910; 923..932; 937..939; 943..953; 956..971
Beta Strand
29..32; 35..38; 41..43; 46..53; 55..58; 67..69; 70..72; 80..86; 96..102; 107..111; 114..120; 124..128; 133..141; 144..148; 152..156; 159..167; 171..173; 177..181; 184..192; 197..199; 203..208; 216..219; 224..226; 231..237; 239..241; 246..248; 258..264; 266..268; 270..279; 286..292; 301..306; 308..310; 560..562; 567..570; 572..574; 593..601; 603..614; 616..618; 620..629; 660..664; 666..669; 671..675; 678..681; 824..827; 831..834; 849..851; 853..857
3D Structure
Electron microscopy (2); X-ray crystallography (13)
Domain & Motif Annotations
Compositional Bias
1041..1059; Polar residues; 1065..1089; Acidic residues
Domain (FT)
24..113; Ig-like C2-type 1; 117..201; Ig-like C2-type 2; 202..306; Ig-like C2-type 3; 319..410; Ig-like C2-type 4; 414..517; Ig-like C2-type 5; 593..954; Protein kinase
Region
1018..1089; Disordered
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- CSF-1/PDGF receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Related Diseases
Acute myeloid leukaemiaBCR-ABL1-negative chronic myeloid leukaemiaBrain cancerBreast cancerColon cancerColorectal cancerGastrointestinal stromal tumourGram-positive bacterial infectionKaposi sarcomaLung cancerMalignant digestive organ neoplasmMastocytosisMultiple myelomaMyelodysplastic syndromePancreatic cancerProstate cancerSolid tumour/cancerStomach cancerThrombocytopenia
Biomarker
Phase 2; Patented; Approved; Investigative; Phase 1; Phase 3
Drug Targets
FDA approved drug targets
Drugs
NILOTINIBFORETINIBNULLORANTINIBAVAPRITINIBSUNITINIBDOVITINIBAXITINIBCEDIRANIBCYC-116RIPRETINIBVATALANIBAST-487VANDETANIBNINTEDANIB ESYLATEXL820TANDUTINIBSORAFENIBIMATINIBDASATINIB ANHYDROUSBECAPLERMINTOVETUMABPAZOPANIBZM447439LINIFANIBBARASERTIB-HQPAX-82RAMUCIRUMABMIDOSTAURINTELATINIBPONATINIBFAMITINIBMOTESANIBAMUVATINIBBARASERTIBENMD-981693XL-820NVP-TAE684MEPOLIZUMABVARGATEFXL-999QUIZARTINIBILORASERTIBPP2CHEMBL:CHEMBL1997335CRENOLANIBMASITINIBPD-0166285OLARATUMABCP-547632REGORAFENIBRG-1530ENMD-2076TAMATINIBPEGPLERANIB SODIUMROMIPLOSTIMLENVATINIBSU-014813TAK-593RABEPRAZOLESERALUTINIBCENISERTIB
Interaction Protein
ENSG00000100311ENSG00000145431ENSG00000146648ENSG00000197461
Interaction Count
4
Interaction Dataset
intact_biogrid