Protein detail

PGFRA

Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)

Entry name
PGFRA
UniProt ID
P16234
EVMP confidence score
0.50
Supporting publications (n)
3
Transmembrane count
1
Protein classification
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information13
Protein Names
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Protein Class (10)
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins
Protein Function (14)
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • CD markers
  • RAS pathway related proteins
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
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Transmembrane
529..549; Helical
Transmembrane Count
1
Ensembl
ENSG00000134853
Entrez Gene Symbol
PDGFRA
Gene Synonym (3)
CD140aGAS9PDGFR2
Gene Description
Platelet derived growth factor receptor alpha
Chromosome
4
Position
54229280-54298245
Supporting publications (n)
3
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue SpecifictestisCell SpecificRetinal pigment epithelial cellsSingle-Nuclei Brain SpecificMGE interneuronSecretome LocationSecreted in other tissuesSecretome FunctionReceptor
Function & Pathway8
Protein Function (14)
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • CD markers
  • RAS pathway related proteins
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
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Cellular Component (13)
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Molecular Function (12)
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Biological Process (3)
KEGG (22)
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Reactome (12)
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Canonical Pathways (2)
  • M117 Pid cone pathway
  • M204 Pid rhodopsin pathway
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence93

Enzyme-Mediated Modification (5)

5 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
PDGFRAPTPRGP23470Y754dephosphorylationSIGNORSIGNOR:25624455
PDGFRAPTPRGP23470Y742dephosphorylationSIGNORSIGNOR:25624455
PDGFRAPTPRGP23470Y754phosphorylationSIGNOR_ProtMapperProtMapperProtMapper:25624455
PDGFRAPTPRGP23470Y742phosphorylationSIGNOR_ProtMapperProtMapperProtMapper:25624455
PDGFRAPDGFRBP09619Y754phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper

Ligand-Receptor Signaling (70)

70 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
plasma_membrane_transmembraneplasma_membrane_transmembraneHPMRNoNoNoYesNo
plasma_membrane_transmembraneplasma_membrane_transmembraneOmniPathNoNoNoYesNo
cell_surfacecell_surfaceSurfaceomeNoNoNoYesNo
cell_surfacecell_surfaceconnectomeDB2020NoNoNoYesNo
cell_surfacecell_surfaceOmniPathNoNoNoYesNo
receptorreceptortalklrNoYesNoYesNo
receptorreceptorCellinkerNoYesNoYesNo
receptorreceptorscConnectNoYesNoYesNo
receptorreceptorconnectomeDB2020NoYesNoYesNo
receptorreceptorCellCallNoYesNoYesNo
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Regulatory Interaction Network (12)

12 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
PGFRBP09619PGFRAP16234YesYesNoWangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperHPRDHINTSignaLink3BioGRIDIntActSPIKE_LCLit-BM-17PhosphoSitePhosphoSite_ProtMapperPhosphoSite:7523122SignaLink3:7523122IntAct:11331882BioGRID:2542288HPRD:1847074Lit-BM-17:11331882HPRD:2161888SignaLink3:21071413SignaLink3:2542288Lit-BM-17:2542288HINT:11331882HPRD:7523122Lit-BM-17:7523122SignaLink3:23331499SPIKE_LC:16189514HPRD:2542288HINT:33961781HINT:2542288
CBLP22681PGFRAP16234YesYesYesSIGNORHPRDHINTSignaLink3ACSNWangSignaLink3:18988627SIGNOR:10347229ACSN:10514377ACSN:17635922HINT:30057274SignaLink3:23331499SignaLink3:9234717HPRD:9234717HINT:9234717
CAV1Q03135PGFRAP16234YesYesNoHPRDSPIKE_LCSignaLink3SignaLink3:18988627SignaLink3:10066366HPRD:10066366SignaLink3:23331499SPIKE_LC:16189514
PDGFCQ9NRA1PGFRAP16234YesYesNoiTALKICELLNETHINTSignaLink3DIPHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDIntActRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdbHPRD:11342471connectomeDB2020:11297552connectomeDB2020:10806482Baccin2019:11342471Cellinker:28267575ICELLNET:9739761LRdb:11342471HPRD:10806482SignaLink3:10806482HINT:11297552HPMR:15207811CellChatDB:15207812DIP:20534510IntAct:20534510IntAct:11297552LRdb:10806482SignaLink3:18988627Cellinker:15207812HPMR:10806482SignaLink3:23331499connectomeDB2020:11342471SignaLink3:11297552Baccin2019:10806482DIP:11297552Baccin2019:11297552SignaLink3:21071413IntAct:10806482LRdb:11297552ICELLNET:15207811HINT:20534510SignaLink3:11342471HINT:10806482CellTalkDB:10806482HPRD:11297552
PDGFAP04085PGFRAP16234YesYesNoiTALKKEGG-MEDICUSICELLNETSIGNORHINTSignaLink3UniProt_LRdbLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdbSignaLink3:11803579Cellinker:28267575ICELLNET:9739761HINT:11297552Lit-BM-17:7679113CellTalkDB:15207811IntAct:25241761Lit-BM-17:15767546Lit-BM-17:2544881CellChatDB:15207812SIGNOR:11803579Baccin2019:152078112544881Lit-BM-17:11297552HPRD:2544881connectomeDB2020:2544881Cellinker:15207812SignaLink3:23331499SignaLink3:21071413HINT:15767546HINT:7679113SignaLink3:2544881Lit-BM-17:25241761HINT:2544881LRdb:15207811ICELLNET:15207811connectomeDB2020:15207811IntAct:7679113LRdb:25
PDGFBP01127PGFRAP16234YesYesNoiTALKKirouac2010KEGG-MEDICUSICELLNETSIGNORHINTSignaLink3UniProt_LRdbLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDCui2007IntActDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSignaLink3:11803579Cellinker:28267575ICELLNET:9739761SIGNOR:11331882HINT:11297552Lit-BM-17:7679113CellTalkDB:15207811Lit-BM-17:15767546Lit-BM-17:9677323Lit-BM-17:2544881CellChatDB:15207812SignaLink3:18988627Lit-BM-17:11297552HPRD:2544881connectomeDB2020:2544881Cellinker:15207812SignaLink3:23331499Lit-BM-17:10806482SignaLink3:21071413HINT:15767546HINT:7679113IntAct:10806482SignaLink3:2544881HINT:9677323HINT:2544881LRdb:15207811ICELLNET:15207811connectomeDB2020:15207811HINT:10806482IntAct:7679113LRdb:25SPIKE_LC:16189514
PGFRAP16234PLCG1P19174YesYesNoKEGG-MEDICUSNCI-PID_ProtMapperPhosphoPointSIGNORProtMapperHPRDCui2007HINTKEAPhosphoSite_KEASignaLink3WangLit-BM-17Lit-BM-17:7535778SIGNOR:7535778KEA:16126727KEA:16153436KEA:8885868HINT:7535778KEA:17081983HINT:7682895KEA:7682059KEA:12601080KEA:15144186ProtMapper:7535778KEA:8657103KEA:1689310KEA:15592455SignaLink3:23331499HPRD:7535778Lit-BM-17:25241761KEA:1708307SignaLink3:7535778KEA:16038803
PGFRAP16234CRKP46108YesYesNoWangPhosphoPointSIGNORELMHINTHPRDSignaLink3IntActSPIKE_LCLit-BM-17Lit-BM-17:10733900ELM:27686861Lit-BM-17:9546424Lit-BM-17:25241761IntAct:25241761SignaLink3:9546424HPRD:9546424IntAct:9546424SIGNOR:19426560SIGNOR:10733900IntAct:10733900SPIKE_LC:16713569HPRD:10733900SignaLink3:23331499HINT:10733900HINT:9546424SignaLink3:10733900ELM:10733900
PTPRGP23470PGFRAP16234YesYesNoSIGNOR_ProtMapperSIGNORProtMapperSIGNOR:25624455ProtMapper:25624455
PGFRAP16234FAK1Q05397YesYesNoiPTMnetSIGNORProtMapperSIGNOR_ProtMapperWangSIGNOR:20802513ProtMapper:20802513
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Protein Complex Composition (5)

5 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
PDGF receptor alpha - PDGF-AA complexPDGFAPDGFRAP04085P162342:2ComplexPortalintact:EBI-9080360PDB:3mjk112975521475529215207811
PDGF receptor alpha - PDGF-AB complexPDGFAPDGFBPDGFRAP01127P04085P162341:1:1ComplexPortalintact:EBI-90837701475529215207811
PDGF receptor alpha - PDGF-BB complexPDGFBPDGFRAP01127P162341:1ComplexPortalintact:EBI-9083388PDB:1pdg1475529215207811
PDGFRA-SHP-2 complexPDGF stimulatedPDGFRAPTPN11P16234Q061241:1CompleatCORUMCompleat:HC1066CORUM:31838943348
SNX complex (SNX1SNX1aSNX2SNX4PDGFRA)PDGFRASNX1SNX2SNX4O60749O95219P16234Q135961:1:1:1CompleatCORUMCORUM:1096Compleat:HC29909819414

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Protein Organic Solvent PrecipitationMass spectrometry132384937
Sequence, Structure & Domains14

Sequences

Length
1,089
Mass
122,670
Sequence
MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P16234-1; Sequence=Displayed; Name=2; IsoId=P16234-2; Sequence=VSP_007833, VSP_007834; Name=3; IsoId=P16234-3; Sequence=VSP_042015, VSP_042016
Alternative Sequence
210..218; ATSELDLEM -> GTCIISFLL (in isoform 2); 219..1089; Missing (in isoform 2); 720..743; YVILSFENNGDYMDMKQADTTQYV -> SGQGCLSSGTLQELSVDLQARGPC (in isoform 3); 744..1089; Missing (in isoform 3)

3D Structural Models

Turn
62..65; 174..176; 777..782; 828..830
Helix
92..94; 103..105; 252..254; 577..579; 584..586; 590..592; 635..651; 682..688; 690..692; 769..774; 792..811; 821..823; 838..840; 843..845; 859..861; 864..869; 874..889; 903..910; 923..932; 937..939; 943..953; 956..971
Beta Strand
29..32; 35..38; 41..43; 46..53; 55..58; 67..69; 70..72; 80..86; 96..102; 107..111; 114..120; 124..128; 133..141; 144..148; 152..156; 159..167; 171..173; 177..181; 184..192; 197..199; 203..208; 216..219; 224..226; 231..237; 239..241; 246..248; 258..264; 266..268; 270..279; 286..292; 301..306; 308..310; 560..562; 567..570; 572..574; 593..601; 603..614; 616..618; 620..629; 660..664; 666..669; 671..675; 678..681; 824..827; 831..834; 849..851; 853..857
3D Structure
Electron microscopy (2); X-ray crystallography (13)

Domain & Motif Annotations

Compositional Bias
1041..1059; Polar residues; 1065..1089; Acidic residues
Domain (FT)
24..113; Ig-like C2-type 1; 117..201; Ig-like C2-type 2; 202..306; Ig-like C2-type 3; 319..410; Ig-like C2-type 4; 414..517; Ig-like C2-type 5; 593..954; Protein kinase
Region
1018..1089; Disordered
Protein Families (3)
  • Protein kinase superfamily
  • Tyr protein kinase family
  • CSF-1/PDGF receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Clinical Relevance9
Disease Involvement (4)
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Related Diseases (19)
Acute myeloid leukaemiaBCR-ABL1-negative chronic myeloid leukaemiaBrain cancerBreast cancerColon cancerColorectal cancerGastrointestinal stromal tumourGram-positive bacterial infectionKaposi sarcomaLung cancerMalignant digestive organ neoplasmMastocytosisMultiple myelomaMyelodysplastic syndromePancreatic cancerProstate cancerSolid tumour/cancerStomach cancerThrombocytopenia
Biomarker
Phase 2; Patented; Approved; Investigative; Phase 1; Phase 3
Drug Targets
FDA approved drug targets
Drugs (62)
NILOTINIBFORETINIBNULLORANTINIBAVAPRITINIBSUNITINIBDOVITINIBAXITINIBCEDIRANIBCYC-116RIPRETINIBVATALANIBAST-487VANDETANIBNINTEDANIB ESYLATEXL820TANDUTINIBSORAFENIBIMATINIBDASATINIB ANHYDROUSBECAPLERMINTOVETUMABPAZOPANIBZM447439LINIFANIBBARASERTIB-HQPAX-82RAMUCIRUMABMIDOSTAURINTELATINIBPONATINIBFAMITINIBMOTESANIBAMUVATINIBBARASERTIBENMD-981693XL-820NVP-TAE684MEPOLIZUMABVARGATEFXL-999QUIZARTINIBILORASERTIBPP2CHEMBL:CHEMBL1997335CRENOLANIBMASITINIBPD-0166285OLARATUMABCP-547632REGORAFENIBRG-1530ENMD-2076TAMATINIBPEGPLERANIB SODIUMROMIPLOSTIMLENVATINIBSU-014813TAK-593RABEPRAZOLESERALUTINIBCENISERTIB
Antibody (2)
HPA004947CAB018143
Interaction Protein (4)
ENSG00000100311ENSG00000145431ENSG00000146648ENSG00000197461
Interaction Count
4
Interaction Dataset
intact_biogrid
Supporting Publications3
PMIDTitleAbstract
30550287Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.No abstract available
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No abstract available
40311616Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer.No abstract available