Protein detail
EPCAM
Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)
Entry name EPCAM | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 4 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)
Protein Class (8)
Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (7)
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Gastrointestinal diseases
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
266..288; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (25)
17-1A323/A3Ber-Ep4BerEp4CD326CO-17AEGP-2EGP34EGP40Ep-CAMESAGA733-2HEA125KS1/4KSALy74M4S1MH99MIC18MK-1MOC-31MOC31TACST-1TACSTD1TROP1
Gene Description
Epithelial cell adhesion molecule
Chromosome
2
Position
47345158-47387601
Supporting publications (n)
4
EVMP confidence score
0.50
Fluorescence & Localization6
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain SpecificastrocyteSecretome LocationSecreted - unknown locationSecretome FunctionReceptor
Function & Pathway7
Protein Function (7)
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Gastrointestinal diseases
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component (7)
Molecular Function (3)
Biological Process (3)
Reactome (13)
- R-hsa-9638630 attachment of bacteria to epithelial cells
- R-hsa-9824439 bacterial infection pathways
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-9734767 developmental cell lineages
- R-hsa-9734779 developmental cell lineages of the integumentary system
- R-hsa-9924644 developmental lineages of the mammary gland
- R-hsa-9927426 developmental lineage of mammary gland alveolar cells
- R-hsa-9927418 developmental lineage of mammary gland luminal epithelial cells
- R-hsa-9927432 developmental lineage of mammary gland myoepithelial cells
- R-hsa-9938206 developmental lineage of mammary stem cells
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Mediation Categories (4)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence42
Ligand-Receptor Signaling (40)
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | LOCATE | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion ChromatographyUltrafiltration | Mass spectrometryWestern blotting | 1 | 38612927 |
Sequence, Structure & Domains10
Sequences
Length
314
Mass
34,932
Sequence
MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVISRKKRMAKYEKAEIKEMGEMHRELNA
3D Structural Models
Turn
73..75; 112..114; 199..201
Helix
65..72; 159..173; 178..180; 209..220; 244..246
Beta Strand
35..40; 46..50; 56..58; 107..111; 115..120; 130..132; 141..150; 181..187; 190..196; 226..228; 234..237; 248..255
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
63..135; Thyroglobulin type-1
Protein Families
EPCAM family
Sequence Similarities
Belongs to the EPCAM family.
Clinical Relevance6
Disease Involvement (4)
Cancer-related genesDisease variantFDA approved drug targetsHereditary nonpolyposis colorectal cancer
Related Diseases (14)
Biomarker
Phase 3; Phase 1; Phase 1/2; Discontinued in Phase 2; Phase 2/3
Drug Targets
FDA approved drug targets
Drugs (25)
EDRECOLOMABADECATUMUMABSOLITOMABCATUMAXOMABTUCOTUZUMAB CELMOLEUKINFREUND'S ADJUVANTKEYHOLE LIMPET HEMOCYANININCOMPLETE FREUND'S ADJUVANTVACCINEDNA VACCINEIGN-101OPORTUZUMAB MONATOXADJUVANTALUM, POTASSIUMLEUCOVORIN CALCIUMALVAC VACCINEING-1HEAVY MINERAL OILCITATUZUMAB BOGATOXTAG-72 ANTIGENMOC31-PERITUXIMABALDESLEUKINANTINEOPLASTIC VACCINELYMPHOKINE-ACTIVATED KILLER CELLS
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 32944195 | Plasma extracellular vesicles detected by Single Molecule array technology as a liquid biopsy for colorectal cancer. | Our results show that CD9-CD63 and Epcam-CD63 SiMoa assays specifically detect extracellular vesicles but not free proteins with high sensitivities. Two extracellular vesicle detection assays, CD9-CD63 and Epcam-CD63, were designed to detect universal extracellular vesicles and tumour-derived extracellular vesicles, respectively. |
| 34295653 | PD-L1 detection on circulating tumor-derived extracellular vesicles (T-EVs) from patients with lung cancer. | In this study, we developed an Epcam-PD-L1 extracellular vesicle (EV) detection prototype using the Simoa platform. This assay detected PD-L1 expression levels on tumor-derived exosomes from the lung cancer cell lines A549 and SK-MES1. |
| 34992371 | EMT-Related Markers in Serum Exosomes are Potential Diagnostic Biomarkers for Invasive Pituitary Adenomas. | Compared with that in the noninvasive group, the expression of N-cad in the exosomes of the invasive group was significantly increased, and the expression of E-cad and Epcam was reduced. E-cadherin, N-cadherin, Epcam, TGF-β, Smad3, and Smad7 were detected in the tissues and exosomes in 10 cases of invasive PAs and 10 cases of noninvasive PAs by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), Western blotting, and immunohistochemical analysis. |