Protein detail
EPCAM
Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)
Protein symbol EPCAM | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)
Protein Class
Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Gastrointestinal diseases
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
266..288; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
17-1A323/A3Ber-Ep4BerEp4CD326CO-17AEGP-2EGP34EGP40Ep-CAMESAGA733-2HEA125KS1/4KSALy74M4S1MH99MIC18MK-1MOC-31MOC31TACST-1TACSTD1TROP1
Gene Description
Epithelial cell adhesion molecule
Chromosome
2
Position
47345158-47387601
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain SpecificastrocyteSecretome LocationSecreted - unknown locationSecretome FunctionReceptor
Function & Pathway
Protein Function
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Gastrointestinal diseases
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-9638630 attachment of bacteria to epithelial cells
- R-hsa-9824439 bacterial infection pathways
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-9734767 developmental cell lineages
- R-hsa-9734779 developmental cell lineages of the integumentary system
- R-hsa-9924644 developmental lineages of the mammary gland
- R-hsa-9927426 developmental lineage of mammary gland alveolar cells
- R-hsa-9927418 developmental lineage of mammary gland luminal epithelial cells
- R-hsa-9927432 developmental lineage of mammary gland myoepithelial cells
- R-hsa-9938206 developmental lineage of mammary stem cells
- R-hsa-109582 hemostasis
- R-hsa-9640148 infection with enterobacteria
- R-hsa-5663205 infectious disease
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| lateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| lateral_cell_membrane | plasma_membrane | Ramilowski_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Ramilowski_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion ChromatographyUltrafiltration | Mass spectrometryWestern blotting | 1 | 38612927 |
Sequence, Structure & Domains
Sequences
Length
314
Mass
34,932
Sequence
MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVISRKKRMAKYEKAEIKEMGEMHRELNA
3D Structural Models
Turn
73..75; 112..114; 199..201
Helix
65..72; 159..173; 178..180; 209..220; 244..246
Beta Strand
35..40; 46..50; 56..58; 107..111; 115..120; 130..132; 141..150; 181..187; 190..196; 226..228; 234..237; 248..255
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
63..135; Thyroglobulin type-1
Protein Families
EPCAM family
Sequence Similarities
Belongs to the EPCAM family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsHereditary nonpolyposis colorectal cancer
Related Diseases
Biomarker
Phase 3; Phase 1; Phase 1/2; Discontinued in Phase 2; Phase 2/3
Drug Targets
FDA approved drug targets
Drugs
EDRECOLOMABADECATUMUMABSOLITOMABCATUMAXOMABTUCOTUZUMAB CELMOLEUKINFREUND'S ADJUVANTKEYHOLE LIMPET HEMOCYANININCOMPLETE FREUND'S ADJUVANTVACCINEDNA VACCINEIGN-101OPORTUZUMAB MONATOXADJUVANTALUM, POTASSIUMLEUCOVORIN CALCIUMALVAC VACCINEING-1HEAVY MINERAL OILCITATUZUMAB BOGATOXTAG-72 ANTIGENMOC31-PERITUXIMABALDESLEUKINANTINEOPLASTIC VACCINELYMPHOKINE-ACTIVATED KILLER CELLS