Protein detail
DPEP1
Dipeptidase 1 (EC 3.4.13.19) (Beta-lactamase) (EC 3.5.2.6) (Dehydropeptidase-I) (Microsomal dipeptidase) (Renal dipeptidase) (hRDP)
Protein symbol DPEP1 | UniProt ID | EVMP score 0.63 |
Frequency 32 | Transmembrane count | Protein classification EnzymesFDA approved drug targetsMetabolic proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Dipeptidase 1 (EC 3.4.13.19) (Beta-lactamase) (EC 3.5.2.6) (Dehydropeptidase-I) (Microsomal dipeptidase) (Renal dipeptidase) (hRDP)
Protein Class
EnzymesFDA approved drug targetsMetabolic proteinsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- Enzymes
- FDA approved drug targets:Small molecule drugs
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Description
Dipeptidase 1
Chromosome
16
Position
89613308-89638456
Frequency
32
EVMP Score
0.63
Fluorescence & Localization
Tissue SpecificintestineBrain Regional Specificchoroid plexusCell SpecificColonocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Enzymes
- FDA approved drug targets:Small molecule drugs
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
- GO:0005515 protein binding
- GO:0008235 metalloexopeptidase activity
- GO:0008270 zinc ion binding
- GO:0008800 beta-lactamase activity
- GO:0016805 dipeptidase activity
- GO:0034235 GPI anchor binding
- GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
- GO:0070573 metallodipeptidase activity
- GO:0072341 modified amino acid binding
Biological Process
Reactome
- R-hsa-5423646 aflatoxin activation and detoxification
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-2142753 arachidonate metabolism
- R-hsa-211859 biological oxidations
- R-hsa-8978868 fatty acid metabolism
- R-hsa-5663205 infectious disease
- R-hsa-9658195 leishmania infection
- R-hsa-9664535 ltc4 cysltr mediated il4 production
- R-hsa-556833 metabolism of lipids
- R-hsa-2142691 synthesis of leukotrienes lt and eoxins ex
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
30 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | Yes |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | Yes |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | Yes |
| peripheral | peripheral | UniProt_location | No | No | No | Yes | Yes |
| peripheral | peripheral | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | Yes |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | Yes |
| apical_cell_membrane | plasma_membrane | Ramilowski_location | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | Ramilowski_location | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | Yes |
Regulatory Interaction Network
0 records.
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| LeukotrieneE4_byDPEP1 | DPEP1 | P16444 | 2 | CellPhoneDBCellChatDBPDB | PDB:1itqPDB:1ituCellPhoneDB:LeukotrieneE4_byDPEP1 | |
| DPEP1SAYSD1STEAP2SUN1TBL2TMEM258TMUB2VMP1 | O94901P16444P61165Q71RG4Q8NFT2Q96GC9Q9NPB0Q9Y4P3 | 0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| DPEP1SUN1TMUB2 | O94901P16444Q71RG4 | 0:0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
411
Mass
45,674
Sequence
MWSGWWLWPLVAVCTADFFRDEAERIMRDSPVIDGHNDLPWQLLDMFNNRLQDERANLTTLAGTHTNIPKLRAGFVGGQFWSVYTPCDTQNKDAVRRTLEQMDVVHRMCRMYPETFLYVTSSAGIRQAFREGKVASLIGVEGGHSIDSSLGVLRALYQLGMRYLTLTHSCNTPWADNWLVDTGDSEPQSQGLSPFGQRVVKELNRLGVLIDLAHVSVATMKATLQLSRAPVIFSHSSAYSVCASRRNVPDDVLRLVKQTDSLVMVNFYNNYISCTNKANLSQVADHLDHIKEVAGARAVGFGGDFDGVPRVPEGLEDVSKYPDLIAELLRRNWTEAEVKGALADNLLRVFEAVEQASNLTQAPEEEPIPLDQLGGSCRTHYGYSSGASSLHRHWGLLLASLAPLVLCLSLL
3D Structural Models
Turn
58..60; 90..93; 113..115; 181..183; 239..241; 305..307; 381..383
Helix
18..27; 39..47; 54..56; 68..73; 87..89; 94..111; 122..131; 143..146; 150..158; 178..180; 194..206; 217..226; 250..259; 269..272; 280..294; 296..298; 321..330; 335..342; 344..356; 370..372
Beta Strand
32..37; 63..65; 76..83; 116..118; 134..141; 161..166; 168..170; 173..175; 188..192; 209..211; 232..235; 262..265; 274..276; 299..301; 359..361; 375..377
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Protein Families
- Metallo-dependent hydrolases superfamily
- Peptidase M19 family
Sequence Similarities
Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Approved
Drug Targets
FDA approved drug targets
Drugs
Interaction Protein
ENSG00000198954
Interaction Count
1
Interaction Dataset
intact_biogrid