Protein detail

GBB3

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (Transducin beta chain 3)

Entry name GBB3	UniProt ID P16520	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsRAS pathway related proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (Transducin beta chain 3)

Protein Class (5)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsRAS pathway related proteins

Protein Function (4)

Disease related genes
Predicted intracellular proteins
RAS pathway related proteins
Human disease related genes:Nervous system diseases:Eye disease

Ensembl

ENSG00000111664

Entrez Gene Symbol

GNB3

Gene Description

G protein subunit beta 3

Chromosome

Position

6839954-6847393

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecificlungCell SpecificBreast lactating cellsSingle-Nuclei Brain Specificdeep-layer near-projectingBlood Lineage Specificdendritic cells

Function & Pathway8

Protein Function (4)

Disease related genes
Predicted intracellular proteins
RAS pathway related proteins
Human disease related genes:Nervous system diseases:Eye disease

Cellular Component (7)

Molecular Function (5)

Biological Process (3)

KEGG (21)

Page 1 of 3

Reactome (61)

Page 1 of 7

Canonical Pathways (2)

M81 Pid cdc42 pathway
M164 Pid erbb1 downstream pathway

Mediation Categories (5)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence21

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network (6)

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GBB3	P16520	PLCG1	P19174	Yes	Yes	No	SIGNOR	SIGNOR:23074268
SMO	Q99835	GBB3	P16520	Yes	Yes	No	SIGNOR	SIGNOR:16885213 SIGNOR:17251915 SIGNOR:23074268
PE2R3	P43115	GBB3	P16520	Yes	Yes	No	SIGNOR	SIGNOR:12038972
FZD3	Q9NPG1	GBB3	P16520	Yes	Yes	No	SIGNOR	SIGNOR:17251915
GBB3	P16520		COMPLEX:P27986_P42336	Yes	Yes	No	SIGNOR	SIGNOR:14668344
GBB3	P16520	PK3CA	P42336	Yes	Yes	No	WangSIGNOR	SIGNOR:14668344

Protein Complex Composition (5)

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
GNAI1-GNB3-GNG12 complex	GNAI1 GNB3 GNG12	P16520 P63096 Q9UBI6	0:0:0	CORUM	CORUM:7088	25733868
GNAI1-GNB3-GNG13 complex	GNAI1 GNB3 GNG13	P16520 P63096 Q9P2W3	0:0:0	CORUM	CORUM:7094	25733868
GNAI1-GNB3-GNG4 complex	GNAI1 GNB3 GNG4	P16520 P50150 P63096	0:0:0	CORUM	CORUM:7033	0
GNAI1-GNB3-GNG8 complex	GNAI1 GNB3 GNG8	P16520 P63096 Q9UK08	0:0:0	CORUM	CORUM:7073	25733868
GNAI1-GNB3-GNGT1 complex	GNAI1 GNB3 GNGT1	P16520 P63096 P63211	0:0:0	CORUM	CORUM:7016	25733868

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	27863537

Sequence, Structure & Domains8

Sequences

Length

340

Mass

37,221

Sequence

MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P16520-1; Sequence=Displayed; Name=2; IsoId=P16520-2; Sequence=VSP_055233

Alternative Sequence

236..278; Missing (in isoform 2)

Domain & Motif Annotations

Repeat

53..83; WD 1; 95..125; WD 2; 141..170; WD 3; 182..212; WD 4; 224..254; WD 5; 268..298; WD 6; 310..340; WD 7

Protein Families

WD repeat G protein beta family

Sequence Similarities

Belongs to the WD repeat G protein beta family.

Clinical Relevance6

Disease Involvement (2)

Congenital stationary night blindnessDisease variant

Drugs (13)

NORTRIPTYLINE BUMETANIDE NULL DIURETIC HYDROCHLOROTHIAZIDE SIBUTRAMINE SUMATRIPTAN HYDRALAZINE / ISOSORBIDE DINITRATE TELMISARTAN OLANZAPINE FUROSEMIDE TORSEMIDE SILDENAFIL

Antibody (2)

HPA040736 HPA074924

Interaction Protein (3)

ENSG00000174021ENSG00000186469ENSG00000242616

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications3

PMID	Title	Abstract
30915084	Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available