Protein detail
GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (Transducin beta chain 3)
Entry name GBB3 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsRAS pathway related proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (Transducin beta chain 3)
Protein Class (5)
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsRAS pathway related proteins
Protein Function (4)
- Disease related genes
- Predicted intracellular proteins
- RAS pathway related proteins
- Human disease related genes:Nervous system diseases:Eye disease
Ensembl
Entrez Gene Symbol
Gene Description
G protein subunit beta 3
Chromosome
12
Position
6839954-6847393
Supporting publications (n)
3
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificlungCell SpecificBreast lactating cellsSingle-Nuclei Brain Specificdeep-layer near-projectingBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function (4)
- Disease related genes
- Predicted intracellular proteins
- RAS pathway related proteins
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component (7)
Molecular Function (5)
Biological Process (3)
KEGG (21)
- hsa04014 Ras signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04082 Neuroactive ligand signaling
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04371 Apelin signaling pathway
- KEGG:hsa04713 Circadian entrainment
- KEGG:hsa04723 Retrograde endocannabinoid signaling
- KEGG:hsa04724 Glutamatergic synapse
- KEGG:hsa04725 Cholinergic synapse
Page 1 of 3
Reactome (61)
- R-hsa-451326 activation of kainate receptors upon glutamate binding
- R-hsa-9660821 adora2b mediated anti inflammatory cytokines production
- R-hsa-418592 adp signalling through p2y purinoceptor 1
- R-hsa-392170 adp signalling through p2y purinoceptor 12
- R-hsa-400042 adrenaline noradrenaline inhibits insulin secretion
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-445717 aquaporin mediated transport
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-4086398 ca2 pathway
- R-hsa-9855142 cellular responses to mechanical stimuli
Page 1 of 7
Canonical Pathways (2)
- M81 Pid cdc42 pathway
- M164 Pid erbb1 downstream pathway
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence21
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | OmniPath | |||||
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | |||
| adhesion | adhesion | OmniPath | Yes | Yes | |||
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | |||
| plasma_membrane | plasma_membrane | Cellinker | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (6)
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GBB3 | P16520 | PLCG1 | P19174 | Yes | Yes | SIGNOR | SIGNOR:23074268 | |
| SMO | Q99835 | GBB3 | P16520 | Yes | Yes | SIGNOR | SIGNOR:16885213SIGNOR:17251915SIGNOR:23074268 | |
| PE2R3 | P43115 | GBB3 | P16520 | Yes | Yes | SIGNOR | SIGNOR:12038972 | |
| FZD3 | Q9NPG1 | GBB3 | P16520 | Yes | Yes | SIGNOR | SIGNOR:17251915 | |
| GBB3 | P16520 | COMPLEX:P27986_P42336 | Yes | Yes | SIGNOR | SIGNOR:14668344 | ||
| GBB3 | P16520 | PK3CA | P42336 | Yes | Yes | WangSIGNOR | SIGNOR:14668344 |
Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GNAI1-GNB3-GNG12 complex | GNAI1GNB3GNG12 | P16520P63096Q9UBI6 | 0:0:0 | CORUM | CORUM:7088 | 25733868 |
| GNAI1-GNB3-GNG13 complex | GNAI1GNB3GNG13 | P16520P63096Q9P2W3 | 0:0:0 | CORUM | CORUM:7094 | 25733868 |
| GNAI1-GNB3-GNG4 complex | GNAI1GNB3GNG4 | P16520P50150P63096 | 0:0:0 | CORUM | CORUM:7033 | 0 |
| GNAI1-GNB3-GNG8 complex | GNAI1GNB3GNG8 | P16520P63096Q9UK08 | 0:0:0 | CORUM | CORUM:7073 | 25733868 |
| GNAI1-GNB3-GNGT1 complex | GNAI1GNB3GNGT1 | P16520P63096P63211 | 0:0:0 | CORUM | CORUM:7016 | 25733868 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 27863537 |
Sequence, Structure & Domains
Sequences
Length
340
Mass
37,221
Sequence
MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P16520-1; Sequence=Displayed; Name=2; IsoId=P16520-2; Sequence=VSP_055233
Alternative Sequence
236..278; Missing (in isoform 2)
Domain & Motif Annotations
Repeat
53..83; WD 1; 95..125; WD 2; 141..170; WD 3; 182..212; WD 4; 224..254; WD 5; 268..298; WD 6; 310..340; WD 7
Protein Families
WD repeat G protein beta family
Sequence Similarities
Belongs to the WD repeat G protein beta family.
Clinical Relevance
Disease Involvement (2)
Congenital stationary night blindnessDisease variant
Related Diseases
Drugs (13)
Interaction Protein (3)
ENSG00000174021ENSG00000186469ENSG00000242616
Interaction Count
3
Interaction Dataset
biogrid_bioplex
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 30915084 | Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton. | No related sentences available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |