Protein detail
INAR1
Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
Protein symbol INAR1 | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 1 | Protein classification Cancer-related genesDisease related genesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
Protein Class
Cancer-related genesDisease related genesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
- FDA approved drug targets:Biotech drugs
Transmembrane
437..457; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
IFNARIFRC
Gene Description
Interferon alpha and beta receptor subunit 1
Chromosome
21
Position
33324387-33359864
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificAlveolar cells type 2Blood Cell Specificplasmacytoid DC
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04060 Cytokine-cytokine receptor interaction
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04217 Necroptosis
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04620 Toll-like receptor signaling pathway
- KEGG:hsa04621 NOD-like receptor signaling pathway
- KEGG:hsa04630 JAK-STAT signaling pathway
- KEGG:hsa04650 Natural killer cell mediated cytotoxicity
- KEGG:hsa05160 Hepatitis C
- KEGG:hsa05161 Hepatitis B
- KEGG:hsa05162 Measles
- KEGG:hsa05164 Influenza A
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
- KEGG:hsa05168 Herpes simplex virus 1 infection
- KEGG:hsa05169 Epstein-Barr virus infection
- KEGG:hsa05171 Coronavirus disease
- KEGG:hsa05200 Pathways in cancer
Reactome
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-9833109 evasion by rsv of host interferon responses
- R-hsa-5663205 infectious disease
- R-hsa-909733 interferon alpha beta signaling
- R-hsa-913531 interferon signaling
- R-hsa-9679191 potential therapeutics for sars
- R-hsa-912694 regulation of ifna ifnb signaling
- R-hsa-9820952 respiratory syncytial virus infection pathway
- R-hsa-9833110 rsv host interactions
- R-hsa-9705671 sars cov 2 activates modulates innate and adaptive immune responses
- R-hsa-9705683 sars cov 2 host interactions
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-9824446 viral infection pathways
Canonical Pathways
- M5882 Naba proteoglycans
- M5884 Naba core matrisome
- M5889 Naba matrisome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
13 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| IFNAR1 | TYK2 | P29597 | Y | 481 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:7526154KEA:7526154KEA:95059042ProtMapper:7526154phosphoELM:7526154 |
| IFNAR1 | TYK2 | P29597 | Y | 466 | phosphorylation | PhosphoNetworksSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:21994561KEA:8700538ProtMapper:8605876ProtMapper:20937132ProtMapper:21949722KEA:9677371ProtMapper:23223197phosphoELM:8700538SIGNOR:8605876phosphoELM:8605876KEA:8605876 |
| IFNAR1 | TYK2 | P29597 | S | 535 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:18166147 |
| IFNAR1 | JAK1 | P23458 | Y | 466 | phosphorylation | Li2012REACH_ProtMapperProtMapper | ProtMapper:25386349 |
| IFNAR1 | JAK1 | P23458 | Y | 481 | phosphorylation | Li2012 | |
| IFNAR1 | MAPK14 | Q16539 | S | 532 | phosphorylation | Sparser_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper | ProtMapper:21695243 |
| IFNAR1 | PRKD2 | Q9BZL6 | S | 535 | phosphorylation | PhosphoSite | |
| IFNAR1 | CSNK1A1 | P48729 | S | 535 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:29793495 |
| IFNAR1 | IL1B | P01584 | S | 535 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:21666722 |
| IFNAR1 | LPA | P08519 | S | 535 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:24480543 |
Page 1 of 2Next
Ligand-Receptor Signaling
67 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
Regulatory Interaction Network
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCD2 | Q9BZL6 | INAR1 | P17181 | Yes | No | No | iPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:26676772PhosphoSite:21865166PhosphoSite:19948722PhosphoSite:23129613PhosphoSite:16551269PhosphoSite:21666722PhosphoSite:21695243PhosphoSite:15337770 |
| MK14 | Q16539 | INAR1 | P17181 | Yes | No | No | Sparser_ProtMapperiPTMnetProtMapperInnateDBPhosphoSitePhosphoSite_ProtMapper | ProtMapper:21695243InnateDB:21695243PhosphoSite:28122987 |
Page 2 of 2Previous
Protein Complex Composition
21 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| IFNAR | IFNAR1IFNAR2 | P17181P48551 | 0:0 | Guide2PharmaCellChatDBKEGG-MEDICUSSIGNORICELLNETCellinkerSPIKE | SIGNOR:SIGNOR-C243 | 234495911151454215032600 |
| IFNAR1-IFNAR2-IFNA2 complex | IFNA2IFNAR1IFNAR2 | P01563P17181P48551 | 1:1:1 | CORUMCellPhoneDBComplexPortalPDB | CORUM:7047PDB:3se3CellPhoneDB:Type_I_IFNRPDB:3SE3 | 14755292309364912185498623046138 |
| IFNAR1-IFNAR2-IFNB1 complex | IFNAR1IFNAR2IFNB1 | P01574P17181P48551 | 1:1:1 | CORUMCompleatComplexPortal | CORUM:552Compleat:HC1290 | 1004974410493588230461381475529230936491 |
| IFNAR1-IFNAR2-IFNW1 complex | IFNAR1IFNAR2IFNW1 | P05000P17181P48551 | 1:1:1 | CORUMComplexPortalPDB | PDB:3se4PDB:3SE4CORUM:7045 | 14755292309364912185498623046138 |
| Interferon alpha receptor-ligand complexIFNA1 variant | IFNA13IFNAR1IFNAR2 | P01562P17181P48551 | 1:1:1 | ComplexPortal | 147552923093649123046138 | |
| Interferon alpha receptor-ligand complexIFNA10 variant | IFNA10IFNAR1IFNAR2 | P01566P17181P48551 | 1:1:1 | ComplexPortal | 147552923093649123046138 | |
| Interferon alpha receptor-ligand complexIFNA14 variant | IFNA14IFNAR1IFNAR2 | P01570P17181P48551 | 1:1:1 | ComplexPortal | 147552923093649123046138 | |
| Interferon alpha receptor-ligand complexIFNA16 variant | IFNA16IFNAR1IFNAR2 | P05015P17181P48551 | 1:1:1 | ComplexPortal | 147552923093649123046138 | |
| Interferon alpha receptor-ligand complexIFNA17 variant | IFNA17IFNAR1IFNAR2 | P01571P17181P48551 | 1:1:1 | ComplexPortal | 147552923093649123046138 | |
| Interferon alpha receptor-ligand complexIFNA21 variant | IFNA21IFNAR1IFNAR2 | P01568P17181P48551 | 1:1:1 | ComplexPortal | 147552923093649123046138 |
Page 1 of 3Next
Isolation & Detection Technology
0 records.
Sequence, Structure & Domains
Sequences
Length
557
Mass
63,525
Sequence
MMVVLLGATTLVLVAVAPWVLSAAAGGKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQIGPPEVHLEAEDKAIVIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVEERIENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIKTTVENELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKWKQIPDCENVKTTQCVFPQNVFQKGIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTPVIQDYPLIYEIIFWENTSNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSVFSDAVCEKTKPGNTSKIWLIVGICIALFALPFVIYAAKVFLRCINYVFFPSLKPSSSIDEYFSEQPLKNLLLSTSEEQIEKCFIIENISTIATVEETNQTDEDHKKYSSQTSQDSGNYSNEDESESKTSEELQQDFV
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P17181-1; Sequence=Displayed; Name=2; Synonyms=Sol-1, Soluble form 1; IsoId=P17181-2; Sequence=VSP_029930, VSP_029931; Name=3; Synonyms=Sol-2, Soluble form 2; IsoId=P17181-3; Sequence=VSP_029928, VSP_029929; Name=4; IsoId=P17181-4; Sequence=VSP_055322
Alternative Sequence
1..69; Missing (in isoform 4); 414..421; Missing (in isoform 3); 428..480; Missing (in isoform 3); 428..434; KTKPGNT -> NISLNSH (in isoform 2); 435..557; Missing (in isoform 2)
3D Structural Models
Turn
172..174; 268..270
Helix
122..125; 207..209; 264..267; 281..283; 295..297
Beta Strand
37..41; 44..48; 60..69; 80..88; 100..107; 112..116; 132..137; 142..147; 164..171; 178..183; 186..189; 197..206; 219..222; 233..240; 243..249; 251..254; 256..263; 286..294; 300..310; 322..325
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
528..539; Polar residues
Domain (FT)
32..126; Fibronectin type-III 1; 127..227; Fibronectin type-III 2; 231..329; Fibronectin type-III 3; 331..432; Fibronectin type-III 4
Region
491..500; Important for interaction with TYK2; 516..557; Disordered
Protein Families
Type II cytokine receptor family
Sequence Similarities
Belongs to the type II cytokine receptor family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targets
Related Diseases
Biomarker
Phase 2
Drug Targets
FDA approved drug targets
Drugs
INTERFERON ALFAPEGINTERFERON ALFA-2ANULLINTERFERON ALFA-N1ALBINTERFERON ALFA-2BINTERFERON ALFA-2BINTERFERON BETA-1BANIFROLUMABINTERFERON ALFA-N3PEGINTERFERON BETA-1APEGINTERFERON ALFACON-1INTERFERON ALFACON-1INTERFERON BETA-1AROPEGINTERFERON ALFA-2BPEGINTERFERON ALFA-2BINTERFERON BETASIFALIMUMABGLATIRAMER
Antibody
Interaction Protein
ENSG00000072803ENSG00000105397
Interaction Count
2
Interaction Dataset
intact_biogrid