Protein detail
ITA2
Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b)
Entry name ITA2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 1 | Protein classification Cancer-related genesCD markersHuman disease related genesPlasma proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b)
Protein Class (5)
Cancer-related genesCD markersHuman disease related genesPlasma proteinsPredicted membrane proteins
Protein Function (3)
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
Transmembrane
1133..1154; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD49B
Gene Description
Integrin subunit alpha 2
Chromosome
5
Position
52989340-53094779
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue Specificbone marrowCell SpecificEarly spermatidsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway7
Protein Function (3)
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
Cellular Component (9)
Molecular Function (11)
- GO:0001540 amyloid-beta binding
- GO:0001618 virus receptor activity
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0005518 collagen binding
- GO:0038064 collagen receptor activity
- GO:0043236 laminin binding
- GO:0043395 heparan sulfate proteoglycan binding
- GO:0044877 protein-containing complex binding
- GO:0046872 metal ion binding
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Biological Process (3)
KEGG (17)
- hsa03271 Virion - Rotavirus
- KEGG:hsa04145 Phagosome
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04820 Cytoskeleton in muscle cells
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Reactome (18)
- R-hsa-447041 chl1 interactions
- R-hsa-3000178 ecm proteoglycans
- R-hsa-1474244 extracellular matrix organization
- R-hsa-109582 hemostasis
- R-hsa-216083 integrin cell surface interactions
- R-hsa-373760 l1cam interactions
- R-hsa-3000157 laminin interactions
- R-hsa-8874081 met activates ptk2 signaling
- R-hsa-8875878 met promotes cell motility
- R-hsa-9856651 mitf m dependent gene expression
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Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence68
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ITGA2 | STK4 | Q13043 | S | 1,180 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling (61)
61 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| integrin | receptor | Integrins | No | Yes | No | Yes | No |
| integrin | receptor | UniProt_keyword | No | Yes | No | Yes | No |
| integrin | receptor | Surfaceome | No | Yes | No | Yes | No |
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Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| COL1A1DMRT1DPF2ITGA2TENT5C | P02452P17301Q5VWP2Q92785Q9Y5R6 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5130 | ||
| COL1A1DMRT1DPF2ITGA2TDP1 | P02452P17301Q92785Q9NUW8Q9Y5R6 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4176 | ||
| COL1A1DMRT1DPF2ITGA2TVP23B | P02452P17301Q92785Q9NYZ1Q9Y5R6 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7146 | ||
| ITGA2 | P17301 | 2 | PDB | PDB:1aoxPDB:5hj2 | ||
| COL26A1ITGA2 | P17301Q96A83 | 2:3 | PDB | PDB:4bj3 |
Sequence, Structure & Domains14
Sequences
Length
1,181
Mass
129,296
Sequence
MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPATQPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTIVQKTSHGHLIFPKQAFDQILQDRNHSSYLGYSVAAISTGESTHFVAGAPRANYTGQIVLYSVNENGNITVIQAHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEEGRVYLFTIKEGILGQHQFLEGPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKILGSDGAFRSHLQYFGRSLDGYGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEASFTPEKITLVNKNAQIILKLCFSAKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNMVVNQAQSCPEHIIYIQEPSDVVNSLDLRVDISLENPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQNLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHSFEDVGPKFIFSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQTSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPTGVIIGSIIAGILLLLALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS
3D Structural Models
Turn
226..228
Helix
188..200; 232..241; 252..262; 266..268; 289..291; 292..301; 313..317; 323..332; 337..340; 348..353; 354..362
Beta Strand
173..180; 208..224; 274..284; 304..311; 341..347
3D Structure
X-ray crystallography (16)
Domain & Motif Annotations
Repeat
34..92; FG-GAP 1; 101..161; FG-GAP 2; 366..420; FG-GAP 3; 423..475; FG-GAP 4; 477..539; FG-GAP 5; 540..598; FG-GAP 6; 602..664; FG-GAP 7
Motif
1157..1161; GFFKR motif
Domain (CC)
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Domain (FT)
188..365; VWFA
Region
1155..1161; Interaction with HPS5
Protein Families
Integrin alpha chain family
Sequence Similarities
Belongs to the integrin alpha chain family.
Clinical Relevance8
Disease Involvement
Cancer-related genes
Related Diseases (2)
Biomarker
Phase 2
Drugs (2)
Interaction Protein (2)
ENSG00000150093ENSG00000179526
Interaction Count
2
Interaction Dataset
intact_biogrid