Protein detail
ITA2
Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b)
Protein symbol ITA2 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 1 | Protein classification Cancer-related genesCD markersHuman disease related genesPlasma proteinsPredicted membrane proteins |
Basic Information
Protein Names
Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b)
Protein Class
Cancer-related genesCD markersHuman disease related genesPlasma proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
Transmembrane
1133..1154; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD49B
Gene Description
Integrin subunit alpha 2
Chromosome
5
Position
52989340-53094779
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificEarly spermatidsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
Cellular Component
Molecular Function
- GO:0001540 amyloid-beta binding
- GO:0001618 virus receptor activity
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0005518 collagen binding
- GO:0038064 collagen receptor activity
- GO:0043236 laminin binding
- GO:0043395 heparan sulfate proteoglycan binding
- GO:0044877 protein-containing complex binding
- GO:0046872 metal ion binding
- GO:0098639 collagen binding involved in cell-matrix adhesion
Biological Process
KEGG
- hsa03271 Virion - Rotavirus
- KEGG:hsa04145 Phagosome
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05222 Small cell lung cancer
- KEGG:hsa05410 Hypertrophic cardiomyopathy
- KEGG:hsa05412 Arrhythmogenic right ventricular cardiomyopathy
- KEGG:hsa05414 Dilated cardiomyopathy
Reactome
- R-hsa-447041 chl1 interactions
- R-hsa-3000178 ecm proteoglycans
- R-hsa-1474244 extracellular matrix organization
- R-hsa-109582 hemostasis
- R-hsa-216083 integrin cell surface interactions
- R-hsa-373760 l1cam interactions
- R-hsa-3000157 laminin interactions
- R-hsa-8874081 met activates ptk2 signaling
- R-hsa-8875878 met promotes cell motility
- R-hsa-9856651 mitf m dependent gene expression
- R-hsa-9730414 mitf m regulated melanocyte development
- R-hsa-9675108 nervous system development
- R-hsa-3000171 non integrin membrane ecm interactions
- R-hsa-75892 platelet adhesion to exposed collagen
- R-hsa-9926550 regulation of mitf m dependent genes involved in extracellular matrix focal adhesion and epithelial to mesenchymal transition
- R-hsa-6806834 signaling by met
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-3000170 syndecan interactions
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ITGA2 | STK4 | Q13043 | S | 1,180 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling
61 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| COL1A1DMRT1DPF2ITGA2TENT5C | P02452P17301Q5VWP2Q92785Q9Y5R6 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5130 | ||
| COL1A1DMRT1DPF2ITGA2TDP1 | P02452P17301Q92785Q9NUW8Q9Y5R6 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4176 | ||
| COL1A1DMRT1DPF2ITGA2TVP23B | P02452P17301Q92785Q9NYZ1Q9Y5R6 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7146 | ||
| ITGA2 | P17301 | 2 | PDB | PDB:1aoxPDB:5hj2 | ||
| COL26A1ITGA2 | P17301Q96A83 | 2:3 | PDB | PDB:4bj3 |
Sequence, Structure & Domains
Sequences
Length
1,181
Mass
129,296
Sequence
MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPATQPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTIVQKTSHGHLIFPKQAFDQILQDRNHSSYLGYSVAAISTGESTHFVAGAPRANYTGQIVLYSVNENGNITVIQAHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEEGRVYLFTIKEGILGQHQFLEGPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKILGSDGAFRSHLQYFGRSLDGYGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEASFTPEKITLVNKNAQIILKLCFSAKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNMVVNQAQSCPEHIIYIQEPSDVVNSLDLRVDISLENPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQNLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHSFEDVGPKFIFSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQTSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPTGVIIGSIIAGILLLLALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS
3D Structural Models
Turn
226..228
Helix
188..200; 232..241; 252..262; 266..268; 289..291; 292..301; 313..317; 323..332; 337..340; 348..353; 354..362
Beta Strand
173..180; 208..224; 274..284; 304..311; 341..347
3D Structure
X-ray crystallography (16)
Domain & Motif Annotations
Repeat
34..92; FG-GAP 1; 101..161; FG-GAP 2; 366..420; FG-GAP 3; 423..475; FG-GAP 4; 477..539; FG-GAP 5; 540..598; FG-GAP 6; 602..664; FG-GAP 7
Motif
1157..1161; GFFKR motif
Domain (CC)
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Domain (FT)
188..365; VWFA
Region
1155..1161; Interaction with HPS5
Protein Families
Integrin alpha chain family
Sequence Similarities
Belongs to the integrin alpha chain family.
Clinical Relevance
Disease Involvement
Cancer-related genes
Related Diseases
Biomarker
Phase 2
Drugs
Interaction Protein
ENSG00000150093ENSG00000179526
Interaction Count
2
Interaction Dataset
intact_biogrid