Protein detail
ANPRC
Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C)
Protein symbol ANPRC | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C)
Protein Class
Disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
Transmembrane
482..504; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
ANPRCC5orf23FLJ14054GUCY2BNPRC
Gene Description
Natriuretic peptide receptor 3
Chromosome
5
Position
32689070-32791724
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificplacentaCell SpecificCytotrophoblastsSingle-Nuclei Brain SpecificastrocyteSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
49 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| guanylyl_cyclase | receptor | HPMR | No | Yes | No | Yes | No |
| kinase | receptor | Surfaceome | No | Yes | No | Yes | No |
| rgc | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
541
Mass
59,808
Sequence
MPSLLVLTFSPCVLLGWALLAGGTGGGGVGGGGGGAGIGGGRQEREALPPQKIEVLVLLPQDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETKDLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRPNVKYPWGPLKLRIDENRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRTQQEESNLGKHRELREDSIRSHFSVA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=NPR-C5; IsoId=P17342-1; Sequence=Displayed; Name=2; Synonyms=NPR-C6; IsoId=P17342-2; Sequence=VSP_001812; Name=3; IsoId=P17342-3; Sequence=VSP_045901, VSP_045902, VSP_001812
Alternative Sequence
1..40; MPSLLVLTFSPCVLLGWALLAGGTGGGGVGGGGGGAGIGG -> MEPSALGPWSLFPDLAPRDQEGQVLAPRRCFRRECGQNEK (in isoform 3); 41..256; Missing (in isoform 3); 476..477; SG -> C (in isoform 2 and isoform 3)
3D Structural Models
Turn
123..125; 167..173; 280..283; 297..299; 345..347; 424..427; 437..440
Helix
69..83; 111..122; 137..150; 162..165; 181..195; 212..227; 244..254; 264..276; 291..293; 309..315; 316..318; 330..344; 356..377; 385..392; 454..456
Beta Strand
52..59; 98..105; 129..132; 154..157; 174..176; 199..205; 208..210; 230..236; 238..240; 256..262; 285..289; 319..324; 393..399; 402..406; 410..412; 415..423; 428..436; 441..444; 451..453
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Protein Families
ANF receptor family
Sequence Similarities
Belongs to the ANF receptor family.
Clinical Relevance
Disease Involvement
Disease variant
Related Diseases
Biomarker
Phase 1
Drug Targets
Clinical trial target
Antibody