Protein detail
CR1
Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)
Protein symbol CR1 | UniProt ID | EVMP score 0.63 |
Frequency 9 | Transmembrane count 1 | Protein classification Blood group antigen proteinsCD markersPlasma proteinsPredicted membrane proteins |
Basic Information
Protein Names
Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)
Protein Class
Blood group antigen proteinsCD markersPlasma proteinsPredicted membrane proteins
Protein Function
- Blood group antigen proteins
- CD markers
Transmembrane
1972..1996; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD35KN
Gene Description
Complement C3b/C4b receptor 1 (Knops blood group)
Chromosome
1
Position
207496147-207641765
Frequency
9
EVMP Score
0.63
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificcerebellar inhibitory
Function & Pathway
Protein Function
- Blood group antigen proteins
- CD markers
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
39 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry [LTQ-FT Ultra]Mass spectrometryWestern blotting | 1 | 27605433 |
Sequence, Structure & Domains
Sequences
Length
2,039
Mass
223,663
Sequence
MGASSPRSPEPVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFSLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDALIVGTLSGTIFFILLIIFLSWIILKHRKGNNAHENPKEVAIHLHSQGGSSVHPRTLQTNEENSRVLP
3D Structural Models
Turn
57..59
Beta Strand
85..88; 91..93; 111..113; 115..119; 126..128; 135..139; 141..147; 149..156; 161..163; 173..175; 180..183; 190..192; 197..201; 212..215; 219..223; 225..228; 950..954; 961..963; 971..973; 977..979; 982..986; 988..990; 1013..1017; 1026..1031; 1035..1039; 1041..1047; 1049..1056; 1060..1063; 1089..1093; 1107..1109; 1113..1116; 1118..1122; 1124..1126
3D Structure
NMR spectroscopy (5); X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
42..101; Sushi 1; 102..163; Sushi 2; 164..234; Sushi 3; 236..295; Sushi 4; 295..355; Sushi 5; 356..418; Sushi 6; 419..489; Sushi 7; 491..551; Sushi 8; 552..613; Sushi 9; 614..684; Sushi 10; 686..745; Sushi 11; 745..805; Sushi 12; 806..868; Sushi 13; 869..939; Sushi 14; 941..1001; Sushi 15; 1002..1063; Sushi 16; 1064..1134; Sushi 17; 1136..1195; Sushi 18; 1195..1255; Sushi 19; 1256..1318; Sushi 20; 1319..1389; Sushi 21; 1394..1454; Sushi 22; 1455..1516; Sushi 23; 1517..1587; Sushi 24; 1589..1648; Sushi 25; 1648..1708; Sushi 26; 1709..1771; Sushi 27; 1772..1842; Sushi 28; 1846..1906; Sushi 29; 1907..1967; Sushi 30
Region
2017..2039; Disordered
Protein Families
Receptors of complement activation (RCA) family
Sequence Similarities
Belongs to the receptors of complement activation (RCA) family.
Clinical Relevance
Related Diseases
Biomarker
Phase 1