EV MemProt Atlas

Basic Information

Protein Names

Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)

Protein Class

Blood group antigen proteinsCD markersPlasma proteinsPredicted membrane proteins

Protein Function

Blood group antigen proteins
CD markers

Transmembrane

1972..1996; Helical

Transmembrane Count

1

Ensembl

ENSG00000203710

Entrez Gene Symbol

CR1

Gene Synonym

CD35KN

Gene Description

Complement C3b/C4b receptor 1 (Knops blood group)

Chromosome

1

Position

207496147-207641765

Frequency

9

EVMP Score

0.63

Fluorescence & Localization

Tissue Specificadrenal glandCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificcerebellar inhibitory

Function & Pathway

Protein Function

Blood group antigen proteins
CD markers

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

37 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

39 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CFI CR1	P05156 P17927	0:0	KEGG-MEDICUS
DECR1 H2AZ2 H2BC21 H2BC5 LARP4B MKI67 MTPAP MUS81 NPM1 RPS28	P06748 P46013 P58876 P62857 Q16698 Q16778 Q71UI9 Q92615 Q96NY9 Q9NVV4	0:0:0:0:0:0:0:0:0:0	hu.MAP
DECR1 H2AZ2 H2BC21 H2BC7 LARP4B MKI67 MTPAP MUS81 NPM1 RPS28	P06748 P46013 P62807 P62857 Q16698 Q16778 Q71UI9 Q92615 Q96NY9 Q9NVV4	0:0:0:0:0:0:0:0:0:0	hu.MAP
CYC1 NDUFS1 SLC25A11 TMED3 UQCR10 UQCRH	P07919 P08574 P28331 Q02978 Q9UDW1 Q9Y3Q3	0:0:0:0:0:0	hu.MAP2
CYC1 UQCR10 UQCRH	P07919 P08574 Q9UDW1	0:0:0	hu.MAP2
UQCR10 UQCRH	P07919 Q9UDW1	0:0	hu.MAP
HNRNPM KRT16 Q5VYJ4 UQCR10	P08779 P52272 Q5VYJ4 Q9UDW1	0:0:0:0	Havugimana2012	Havugimana2012:C_157
KLHDC10 PYCR1	P32322 Q6PID8	0:0	hu.MAP
DECR1 HSD17B4	P51659 Q16698	0:0	hu.MAP
ASPSCR1 VCP	P55072 Q9BZE9	2:2	hu.MAP2PDB	PDB:5ifwPDB:5ifs

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry [LTQ-FT Ultra]Mass spectrometryWestern blotting	1	27605433

Sequence, Structure & Domains

Sequences

Length

2,039

Mass

223,663

Sequence

MGASSPRSPEPVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFSLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDALIVGTLSGTIFFILLIIFLSWIILKHRKGNNAHENPKEVAIHLHSQGGSSVHPRTLQTNEENSRVLP

3D Structural Models

Turn

57..59

Beta Strand

85..88; 91..93; 111..113; 115..119; 126..128; 135..139; 141..147; 149..156; 161..163; 173..175; 180..183; 190..192; 197..201; 212..215; 219..223; 225..228; 950..954; 961..963; 971..973; 977..979; 982..986; 988..990; 1013..1017; 1026..1031; 1035..1039; 1041..1047; 1049..1056; 1060..1063; 1089..1093; 1107..1109; 1113..1116; 1118..1122; 1124..1126

3D Structure

NMR spectroscopy (5); X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)

42..101; Sushi 1; 102..163; Sushi 2; 164..234; Sushi 3; 236..295; Sushi 4; 295..355; Sushi 5; 356..418; Sushi 6; 419..489; Sushi 7; 491..551; Sushi 8; 552..613; Sushi 9; 614..684; Sushi 10; 686..745; Sushi 11; 745..805; Sushi 12; 806..868; Sushi 13; 869..939; Sushi 14; 941..1001; Sushi 15; 1002..1063; Sushi 16; 1064..1134; Sushi 17; 1136..1195; Sushi 18; 1195..1255; Sushi 19; 1256..1318; Sushi 20; 1319..1389; Sushi 21; 1394..1454; Sushi 22; 1455..1516; Sushi 23; 1517..1587; Sushi 24; 1589..1648; Sushi 25; 1648..1708; Sushi 26; 1709..1771; Sushi 27; 1772..1842; Sushi 28; 1846..1906; Sushi 29; 1907..1967; Sushi 30

Region

2017..2039; Disordered

Protein Families

Receptors of complement activation (RCA) family

Sequence Similarities

Belongs to the receptors of complement activation (RCA) family.

Clinical Relevance

Related Diseases

Retinopathy

Biomarker

Phase 1

Drugs

MIROCOCEPT TETANUS TOXOID CDX-1135 COMPOUND 30 [PMID: 15953724]

Antibody

CAB002491 CAB016271 HPA042455 HPA043579 HPA049348

Protein symbol CR1	UniProt ID P17927	EVMP score 0.63
Frequency 9	Transmembrane count 1	Protein classification Blood group antigen proteinsCD markersPlasma proteinsPredicted membrane proteins