Protein detail
CR1
Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)
Entry name CR1 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 9 | Transmembrane count 1 | Protein classification Blood group antigen proteinsCD markersPlasma proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)
Protein Class (4)
Blood group antigen proteinsCD markersPlasma proteinsPredicted membrane proteins
Protein Function (2)
- Blood group antigen proteins
- CD markers
Transmembrane
1972..1996; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
CD35KN
Gene Description
Complement C3b/C4b receptor 1 (Knops blood group)
Chromosome
1
Position
207496147-207641765
Supporting publications (n)
9
EVMP confidence score
0.63
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificcerebellar inhibitory
Function & Pathway
Protein Function (2)
- Blood group antigen proteins
- CD markers
Cellular Component (8)
Molecular Function (6)
Biological Process (3)
KEGG (7)
Reactome (6)
Mediation Categories (4)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence77
Ligand-Receptor Signaling (37)
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | Yes | Yes | |||
| receptor | receptor | ICELLNET | Yes | Yes | |||
| receptor | receptor | CellTalkDB | Yes | Yes | |||
| receptor | receptor | Ramilowski2015 | Yes | Yes | |||
| receptor | receptor | LRdb | Yes | Yes | |||
| innate_immune | receptor | ICELLNET | Yes | Yes | |||
| innate_immune_complement | receptor | ICELLNET | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| extracellular | extracellular | DGIdb | Yes | ||||
| extracellular | extracellular | OmniPath | Yes |
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Protein Complex Composition (39)
39 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ASPSCR1VCPVCPKMT | P55072Q9BZE9Q9H867 | 1:1:1 | hu.MAP2PDB | PDB:7oat | ||
| ASPSCR1NSFL1CVCPVCPKMT | P55072Q9BZE9Q9H867Q9UNZ2 | 0:0:0:0 | hu.MAP2 | |||
| ASPSCR1UBXN2AUBXN6VCF1VCPKMT | P68543Q969W3Q9BZE9Q9BZV1Q9H867 | 0:0:0:0:0 | hu.MAP2 | |||
| ASPSCR1UBXN2AUBXN6VCPKMT | P68543Q9BZE9Q9BZV1Q9H867 | 0:0:0:0 | hu.MAP2 | |||
| DECR1 | Q16698 | 4 | PDB | PDB:1w8dPDB:1w73PDB:1w6u | ||
| DECR1FAM118B | Q16698Q9BPY3 | 0:0 | hu.MAP2 | |||
| CCHCR1IQCC | Q4KMZ1Q8TD31 | 0:0 | hu.MAP2 | |||
| ASPSCR1FGGYGNPNAT1NSFL1CVCF1 | Q969W3Q96C11Q96EK6Q9BZE9Q9UNZ2 | 0:0:0:0:0 | hu.MAP2 | |||
| ASPSCR1VCF1 | Q969W3Q9BZE9 | 0:0 | hu.MAP |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry [LTQ-FT Ultra]Mass spectrometryWestern blotting | 1 | 27605433 |
Sequence, Structure & Domains
Sequences
Length
2,039
Mass
223,663
Sequence
MGASSPRSPEPVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFSLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDALIVGTLSGTIFFILLIIFLSWIILKHRKGNNAHENPKEVAIHLHSQGGSSVHPRTLQTNEENSRVLP
3D Structural Models
Turn
57..59
Beta Strand
85..88; 91..93; 111..113; 115..119; 126..128; 135..139; 141..147; 149..156; 161..163; 173..175; 180..183; 190..192; 197..201; 212..215; 219..223; 225..228; 950..954; 961..963; 971..973; 977..979; 982..986; 988..990; 1013..1017; 1026..1031; 1035..1039; 1041..1047; 1049..1056; 1060..1063; 1089..1093; 1107..1109; 1113..1116; 1118..1122; 1124..1126
3D Structure
NMR spectroscopy (5); X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
42..101; Sushi 1; 102..163; Sushi 2; 164..234; Sushi 3; 236..295; Sushi 4; 295..355; Sushi 5; 356..418; Sushi 6; 419..489; Sushi 7; 491..551; Sushi 8; 552..613; Sushi 9; 614..684; Sushi 10; 686..745; Sushi 11; 745..805; Sushi 12; 806..868; Sushi 13; 869..939; Sushi 14; 941..1001; Sushi 15; 1002..1063; Sushi 16; 1064..1134; Sushi 17; 1136..1195; Sushi 18; 1195..1255; Sushi 19; 1256..1318; Sushi 20; 1319..1389; Sushi 21; 1394..1454; Sushi 22; 1455..1516; Sushi 23; 1517..1587; Sushi 24; 1589..1648; Sushi 25; 1648..1708; Sushi 26; 1709..1771; Sushi 27; 1772..1842; Sushi 28; 1846..1906; Sushi 29; 1907..1967; Sushi 30
Region
2017..2039; Disordered
Protein Families
Receptors of complement activation (RCA) family
Sequence Similarities
Belongs to the receptors of complement activation (RCA) family.
Clinical Relevance
Related Diseases
Biomarker
Phase 1
Supporting Publications9
| PMID | Title | Related sentences |
|---|---|---|
| 32230970 | Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles. | No related sentences available |
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No related sentences available |
| 36064647 | Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells. | No related sentences available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38354507 | Separation of high-purity plasma extracellular vesicles for investigating proteomic signatures in diabetic retinopathy. | No related sentences available |
| 40465195 | Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome. | No related sentences available |
| 40840701 | Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma. | No related sentences available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No related sentences available |