EV MemProt Atlas

Basic Information13

Protein Names

Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)

Protein Class (4)

Blood group antigen proteinsCD markersPlasma proteinsPredicted membrane proteins

Protein Function (2)

Blood group antigen proteins
CD markers

Transmembrane

1972..1996; Helical

Transmembrane Count

1

Ensembl

ENSG00000203710

Entrez Gene Symbol

CR1

Gene Synonym (2)

CD35KN

Gene Description

Complement C3b/C4b receptor 1 (Knops blood group)

Chromosome

1

Position

207496147-207641765

Supporting publications (n)

9

EVMP confidence score

0.63

Fluorescence & Localization4

Tissue Specificadrenal glandCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificcerebellar inhibitory

Function & Pathway7

Protein Function (2)

Blood group antigen proteins
CD markers

Cellular Component (8)

Molecular Function (6)

Biological Process (3)

KEGG (7)

Reactome (6)

Mediation Categories (4)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence77

Ligand-Receptor Signaling (37)

37 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	Cellinker	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Protein Complex Composition (39)

39 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Cytochrome bc1 complex (Ubiquinol-cytochrome c reductase complexcomplex III)	CYC1 MT-CYB UQCR10 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRQ	O14949 P00156 P07919 P08574 P14927 P22695 P31930 P47985 Q9UDW1	1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2553	10873857
Cytochrome bc1-complex (EC 1.10.2.2)mitochondrial	CYC1 MT-CYB UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRHL UQCRQ	A0A096LP55 O14949 O14957 P00156 P07919 P08574 P14927 P22695 P31930 P47985 Q9UDW1	1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC340	16120479
Cytochrome bc1-complex (EC 1.10.2.2)mitochondrial	CYC1 UQCR10	P08574 Q9UDW1	1:1	Compleat	Compleat:HC3304	12794875
HT_DM_Cluster150	PDHA1 PDHA2 SLC6A1 SLC6A13 TMCO1 UQCR11	O14957 P08559 P29803 P30531 Q9NSD5 Q9UM00	1:1:1:1:1:1	Compleat	Compleat:HC25	22036573
Mitochondrial respiratory chain complex III	CYC1 MT-CYB UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRQ	O14949 O14957 P00156 P07919 P08574 P14927 P22695 P31930 P47985 Q9UDW1	1:1:1:1:1:1:1:1:2:1	KEGG-MEDICUSSIGNORComplexPortalPDB	PDB:5xteSIGNOR:SIGNOR-C279PDB:5XTEintact:EBI-1224506PDB:9cg3	16937356 14755292 10066163 28844695
Pyrroline-5-carboxylate reductase 1 complex	PYCR1	P32322	5	ComplexPortalPDB	PDB:8tcxPDB:8tdcPDB:8td5PDB:8tcyPDB:8tcvPDB:8tddPDB:5uauPDB:5uaxPDB:8td7PDB:6xozPDB:8td9PDB:8td6PDB:8td2PDB:2gerPDB:8tczPDB:8tdbPDB:8tcwPDB:2graPDB:6xp0PDB:8td1PDB:8vrePDB:8dkgPDB:8tcuPDB:8td8PDB:5uavPDB:5uawPDB:6xp2PDB:8td4intact:EBI-848646PDB:2gr9PDB:8td0PDB:6xp1PDB:8td3PDB:6xp3PDB:2izzPDB:5uat	14755292
	CYC1 MT-CYB UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRHL UQCRQ	A0A096LP55 O14949 O14957 P00156 P08574 P14927 P22695 P31930 P47985 Q9UDW1	0:0:0:0:0:0:0:0:0:0	KEGG-MEDICUS
	CLPTM1L PTGES2 UQCR11 UQCRQ	O14949 O14957 Q96KA5 Q9H7Z7	0:0:0:0	Havugimana2012	Havugimana2012:C_370
	CYC1 IMMT MT-CYB SLC25A31 UBC UQCR10 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRQ	O14949 P00156 P08574 P0CG48 P14927 P22695 P31930 P47985 Q16891 Q9H0C2 Q9UDW1	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8624
	CYC1 ERCC8 HSPA13 IMMT SLC25A31 UBC UQCR10 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRQ	O14949 P08574 P0CG48 P14927 P22695 P31930 P47985 P48723 Q13216 Q16891 Q9H0C2 Q9UDW1	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4710

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry [LTQ-FT Ultra]Mass spectrometryWestern blotting	1	27605433

Sequence, Structure & Domains10

Sequences

Length

2,039

Mass

223,663

Sequence

MGASSPRSPEPVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFSLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDALIVGTLSGTIFFILLIIFLSWIILKHRKGNNAHENPKEVAIHLHSQGGSSVHPRTLQTNEENSRVLP

3D Structural Models

Turn

57..59

Beta Strand

85..88; 91..93; 111..113; 115..119; 126..128; 135..139; 141..147; 149..156; 161..163; 173..175; 180..183; 190..192; 197..201; 212..215; 219..223; 225..228; 950..954; 961..963; 971..973; 977..979; 982..986; 988..990; 1013..1017; 1026..1031; 1035..1039; 1041..1047; 1049..1056; 1060..1063; 1089..1093; 1107..1109; 1113..1116; 1118..1122; 1124..1126

3D Structure

NMR spectroscopy (5); X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)

42..101; Sushi 1; 102..163; Sushi 2; 164..234; Sushi 3; 236..295; Sushi 4; 295..355; Sushi 5; 356..418; Sushi 6; 419..489; Sushi 7; 491..551; Sushi 8; 552..613; Sushi 9; 614..684; Sushi 10; 686..745; Sushi 11; 745..805; Sushi 12; 806..868; Sushi 13; 869..939; Sushi 14; 941..1001; Sushi 15; 1002..1063; Sushi 16; 1064..1134; Sushi 17; 1136..1195; Sushi 18; 1195..1255; Sushi 19; 1256..1318; Sushi 20; 1319..1389; Sushi 21; 1394..1454; Sushi 22; 1455..1516; Sushi 23; 1517..1587; Sushi 24; 1589..1648; Sushi 25; 1648..1708; Sushi 26; 1709..1771; Sushi 27; 1772..1842; Sushi 28; 1846..1906; Sushi 29; 1907..1967; Sushi 30

Region

2017..2039; Disordered

Protein Families

Receptors of complement activation (RCA) family

Sequence Similarities

Belongs to the receptors of complement activation (RCA) family.

Clinical Relevance4

Related Diseases

Retinopathy

Biomarker

Phase 1

Drugs (4)

MIROCOCEPT TETANUS TOXOID CDX-1135 COMPOUND 30 [PMID: 15953724]

Antibody (5)

CAB002491 CAB016271 HPA042455 HPA043579 HPA049348

Supporting Publications9

PMID	Title	Abstract
32230970	Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.	No abstract available
33592500	A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.	No abstract available
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38354507	Separation of high-purity plasma extracellular vesicles for investigating proteomic signatures in diabetic retinopathy.	No abstract available
40465195	Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome.	No abstract available
40840701	Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma.	No abstract available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No abstract available

Entry name CR1	UniProt ID P17927	EVMP confidence score 0.63
Supporting publications (n) 9	Transmembrane count 1	Protein classification Blood group antigen proteinsCD markersPlasma proteinsPredicted membrane proteins