Protein detail

VGFR1

Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)

Entry name VGFR1	UniProt ID P17948	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Class

Cancer-related genesDisease related genesEnzymesFDA approved drug targetsPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins

Protein Function

ENZYME proteins:Transferases
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs
FDA approved drug targets:Biotech drugs

Transmembrane

759..780; Helical

Transmembrane Count

Ensembl

ENSG00000102755

Entrez Gene Symbol

FLT1

Gene Synonym

FLTVEGFR1

Gene Description

Fms related receptor tyrosine kinase 1

Chromosome

Position

28300346-28495145

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway

Protein Function

ENZYME proteins:Transferases
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

20 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
FLT1	VEGFA	P15692	Y	1,213	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:22348123
FLT1	VEGFA	P15692	Y	1,048	phosphorylation	REACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:21441409
FLT1	PGF	P49763	Y	1,213	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:27009237
FLT1	PGF	P49763	Y	1,333	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:29193887
FLT1	VEGFB	P49765	Y	1,213	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:29397867
FLT1	VEGFB	P49765	Y	1,309	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:29397867
FLT1	PIGF	Q07326	Y	1,213	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:22177802
FLT1	INSR	P06213	Y	1,169	phosphorylation	KEA	KEA:17570479
FLT1	INSR	P06213	Y	1,242	phosphorylation	KEA	KEA:17570479
FLT1	INSR	P06213	Y	794	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling

69 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
secreted	secreted	Cellinker	No	No	Yes	Yes	No
secreted	secreted	OmniPath	No	No	Yes	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	Yes	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	Yes	Yes	No
cell_surface	cell_surface	OmniPath	No	No	Yes	Yes	No
receptor	receptor	talklr	No	Yes	Yes	Yes	No
receptor	receptor	Cellinker	No	Yes	Yes	Yes	No
receptor	receptor	scConnect	No	Yes	Yes	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	Yes	Yes	No
receptor	receptor	CellCall	No	Yes	Yes	Yes	No

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Regulatory Interaction Network

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
VGFR1	P17948	PLCG1	P19174	Yes	Yes	No	PhosphoPointSIGNORHPRDSignaLink3Li2012WangLit-BM-17	SignaLink3:18988627 Lit-BM-17:23397142 Lit-BM-17:9398617 SignaLink3:11312102 SIGNOR:9398617 HPRD:9600074 HPRD:9398617 SignaLink3:9398617 HPRD:9299537 SignaLink3:23331499 SignaLink3:9600074 HPRD:11312102 SignaLink3:9299537
VEGFB	P49765	VGFR1	P17948	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETProtMapperHINTSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDDLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDCellinkerREACH_ProtMapperSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbSparser_ProtMapperHPMR_CellinkerconnectomeDB2020LRdb	HINT:9751730 HINT:10409677 connectomeDB2020:97517301LRdb:98ICELLNET:26285753 ICELLNET:11181169 Cellinker:9751730 SignaLink3:10409677 SignaLink3:9751730 SignaLink3:18988627 HPRD:9751730 CellChatDB:16633338 SignaLink3:23331499 SignaLink3:21071413 CellTalkDB:9751730 ProtMapper:29397867 connectomeDB2020:9751730 BioGRID:10409677 HINT:20501651 LRdb:97517301
VGFR1	P17948	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:33139573
VEGFA	P15692	VGFR1	P17948	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETProtMapperSIGNORHINTUniProt_LRdbDIPLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDIntActDLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDCellinkerREACH_ProtMapperSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbSparser_ProtMapperHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb	SIGNOR:14704231 BioGRID:35874709 SPIKE_LC:17145710 Cellinker:15637071 connectomeDB2020:9393862 DIP:8631822 IntAct:20660291 Lit-BM-17:8631822 ICELLNET:26285753 HINT:35874709 HINT:8621427 HPRD:9393862 Lit-BM-17:10543948 connectomeDB2020:17051153 Cellinker:8621427 HINT:9393862 Lit-BM-17:21939755 ProtMapper:22348123 DIP:8621427 Lit-BM-17:9393862 HINT:10543948 ProtMapper:27009237 connectomeDB2020:8621427 CellChatDB:16633338 HINT:20660291 HINT:21939755 HPRD:8621427 HPRD:17051153 HINT:28111021 HINT:33961781 LRdb:17051153 LRdb:15637071 CellTalkDB:17051153 IntAct:33961781 IntAct:10543948 Lit-BM-17:8621427 ProtMapper:21441409 connectomeDB2020:15637071 Cellinker:17051153 Cellinker:9393862 LRdb:9393862 LRdb:8621427 IntAct:9393862 HPMR:8356051
PTPRJ	Q12913	VGFR1	P17948	Yes	No	Yes	SIGNORIntAct	IntAct:16893970 SIGNOR:12771128 IntAct:12771128
VGFR1	P17948	LGUL	Q04760	Yes	Yes	No	SIGNOR	SIGNOR:34838714

Protein Complex Composition

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
FLT1_complex	FLT1 KDR	P17948 P35968	1:1	CellPhoneDBCellChatDBICELLNET	CellPhoneDB:FLT1_complex	22828632 11181169 8806634
	FLT1 VEGFA	P15692 P17948	2:2	hu.MAP2PDB	PDB:5t89PDB:1qtyPDB:1flt
	FLT1	P17948	4	PDB	PDB:4cl7PDB:5abd
	FLT1 PGF	P17948 P49763	2:2	PDB	PDB:1rv6
	FLT1 VEGFB	P17948 P49765	2:2	PDB	PDB:2xac
	FLT1 SMYD3	P17948 Q9H7B4	1:1	PDB	PDB:5ex3

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western Blotting	1	37353784

Sequence, Structure & Domains

Sequences

Length

1,338

Mass

150,769

Sequence

MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISAPKFNSGSSDDVRYVNAFKFMSLERIKTFEELLPNATSMFDDYQGDSSTLLASPMLKRFTWTDSKPKASLKIDLRVTSKSKESGLSDVSRPSFCHSSCGHVSEGKRRFTYDHAELERKIACCSPPPDYNSVVLYSTPPI

Alternative Products

Event=Alternative splicing; Named isoforms=8; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Flt1; IsoId=P17948-1; Sequence=Displayed; Name=2; Synonyms=sFlt1; IsoId=P17948-2; Sequence=VSP_002955, VSP_002956; Name=3; Synonyms=sFlt1-14; IsoId=P17948-3; Sequence=VSP_041927, VSP_041928; Name=4; IsoId=P17948-4; Sequence=VSP_041929, VSP_041930; Name=5; Synonyms=i15; IsoId=P17948-5; Sequence=VSP_041985; Name=6; Synonyms=i18; IsoId=P17948-6; Sequence=VSP_041984; Name=7; Synonyms=i21; IsoId=P17948-7; Sequence=VSP_041983; Name=8; IsoId=P17948-8; Sequence=VSP_047759, VSP_047760

Alternative Sequence

1..995; Missing (in isoform 7); 1..875; Missing (in isoform 6); 1..782; Missing (in isoform 5); 1..7; MVSYWDT -> MNSDLLV (in isoform 8); 8..984; Missing (in isoform 8); 518..541; MASTLVVADSRISGIYICIASNKV -> LPPANSSFMLPPTSFSSNYFHFLP (in isoform 4); 542..1338; Missing (in isoform 4); 657..687; DQEAPYLLRNLSDHTVAISSSTTLDCHANGV -> GEHCNKKAVFSRISKFKSTRNDCTTQSNVKH (in isoform 2); 688..1338; Missing (in isoform 2); 706..733; GIILGPGSSTLFIERVTEEDEGVYHCKA -> ELYTSTSPSSSSSSPLSSSSSSSSSSSS (in isoform 3); 734..1338; Missing (in isoform 3)

3D Structural Models

Turn

130..132; 172..174; 188..190; 1015..1017; 1047..1049; 1114..1116

Helix

163..165; 199..201; 806..809; 817..820; 824..826; 849..851; 869..883; 917..922; 996..1014; 1025..1027; 1032..1034; 1042..1044; 1063..1065; 1068..1073; 1078..1093; 1107..1113; 1127..1136; 1141..1143; 1147..1157

Beta Strand

135..137; 140..142; 144..148; 150..152; 154..156; 160..162; 168..171; 175..177; 181..187; 191..196; 203..211; 214..224; 827..835; 837..848; 854..863; 894..898; 906..910; 1028..1030; 1036..1038; 1053..1055

3D Structure

NMR spectroscopy (2); X-ray crystallography (10)

Domain & Motif Annotations

Compositional Bias

940..957; Basic and acidic residues; 959..971; Polar residues

Domain (CC)

The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFA binding.

Domain (FT)

32..123; Ig-like C2-type 1; 151..214; Ig-like C2-type 2; 230..327; Ig-like C2-type 3; 335..421; Ig-like C2-type 4; 428..553; Ig-like C2-type 5; 556..654; Ig-like C2-type 6; 661..747; Ig-like C2-type 7; 827..1158; Protein kinase

Region

940..982; Disordered

Protein Families

Protein kinase superfamily
Tyr protein kinase family
CSF-1/PDGF receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesFDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs

REGORAFENIB NULL LENVATINIB MESYLATE SU-014813 CEP-5214 SUNITINIB GLESATINIB XL820 PTC299 XL999 CENISERTIB NINTEDANIB ESYLATE CEDIRANIB PAZOPANIB VATALANIB SORAFENIB BARASERTIB-HQPA ALISERTIB MOTESANIB FRUQUINTINIB VANDETANIB X-82 TG100-801 GO-6976 MUPARFOSTAT TABERMINOGENE VADENOVEC ENMD-2076 CEP-7055 AST-487 RG-1530 BRIVANIB AXITINIB TIVOZANIB VEGF RECEPTOR TYROSINE KINASE INHIBITOR III BRIVANIB ALANINATE JNJ-7706621 LUCITANIB DOVITINIB FAMITINIB LINIFANIB PD-0166285 VEGFRECINE CEP-11981 SP-600125 ILORASERTIB TELBERMIN FORETINIB CP-547632 TELATINIB AGN-211745 IBCASERTIB TIVOZANIB HYDROCHLORIDE 4SC-203 AEE-788 XL-820 NVP-TAE684 VARGATEF EW-A-401 CYC-116 TESEVATINIB RABEPRAZOLE L-21649 ICRUCUMAB DORAMAPIMOD SEMAXANIB ENTRECTINIB TAMATINIB PEGPLERANIB SODIUM ERLOTINIB KENPAULLONE LENVATINIB AG-13958 CP-459632 OSI-930 TAK-593 TOZASERTIB CHEMBL:CHEMBL1997335 BMS-690514 PF-562271 ABICIPAR PEGOL SULFATINIB ORANTINIB XL-999 GW843682X

Antibody

HPA011740 HPA014290 CAB068189 CAB068190

Interaction Protein

ENSG00000099942ENSG00000112715ENSG00000145675

Interaction Count

Interaction Dataset

intact_biogrid