Protein detail

VGFR1

Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)

Entry name VGFR1	UniProt ID P17948	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Class

Cancer-related genesDisease related genesEnzymesFDA approved drug targetsPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins

Protein Function

ENZYME proteins:Transferases
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs
FDA approved drug targets:Biotech drugs

Transmembrane

759..780; Helical

Transmembrane Count

Ensembl

ENSG00000102755

Entrez Gene Symbol

FLT1

Gene Synonym

FLTVEGFR1

Gene Description

Fms related receptor tyrosine kinase 1

Chromosome

Position

28300346-28495145

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway

Protein Function

ENZYME proteins:Transferases
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

20 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
FLT1	PTPN11	Q06124	Y	1,213	dephosphorylation	HPRD	HPRD:9600074
FLT1	KDR	P35968	Y	1,169	phosphorylation	Li2012
FLT1	KDR	P35968	Y	1,333	phosphorylation	Li2012
FLT1	KDR	P35968	Y	1,213	phosphorylation	Li2012
FLT1	KDR	P35968	Y	794	phosphorylation	Li2012
FLT1	FLT4	P35916	Y	1,169	phosphorylation	Li2012
FLT1	FLT4	P35916	Y	1,333	phosphorylation	Li2012
FLT1	FLT4	P35916	Y	1,213	phosphorylation	Li2012
FLT1	FLT4	P35916	Y	794	phosphorylation	Li2012
FLT1	VEGFA	P15692	Y	1,053	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:21441409

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Ligand-Receptor Signaling

69 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	iTALK	No	Yes	Yes	Yes	No
growth_factor	receptor	iTALK	No	Yes	Yes	Yes	No
receptor	receptor	Almen2009	No	Yes	Yes	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	Yes	Yes	No
tyrosine_kinase	receptor	HGNC	No	Yes	Yes	Yes	No
receptor	receptor	HGNC	No	Yes	Yes	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	Yes	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No

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Regulatory Interaction Network

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
VGFR1	P17948	PLCG1	P19174	Yes	Yes	No	PhosphoPointSIGNORHPRDSignaLink3Li2012WangLit-BM-17	SignaLink3:18988627 Lit-BM-17:23397142 Lit-BM-17:9398617 SignaLink3:11312102 SIGNOR:9398617 HPRD:9600074 HPRD:9398617 SignaLink3:9398617 HPRD:9299537 SignaLink3:23331499 SignaLink3:9600074 HPRD:11312102 SignaLink3:9299537
VEGFB	P49765	VGFR1	P17948	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETProtMapperHINTSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDDLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDCellinkerREACH_ProtMapperSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbSparser_ProtMapperHPMR_CellinkerconnectomeDB2020LRdb	HINT:9751730 HINT:10409677 connectomeDB2020:97517301LRdb:98ICELLNET:26285753 ICELLNET:11181169 Cellinker:9751730 SignaLink3:10409677 SignaLink3:9751730 SignaLink3:18988627 HPRD:9751730 CellChatDB:16633338 SignaLink3:23331499 SignaLink3:21071413 CellTalkDB:9751730 ProtMapper:29397867 connectomeDB2020:9751730 BioGRID:10409677 HINT:20501651 LRdb:97517301
VGFR1	P17948	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:33139573
VEGFA	P15692	VGFR1	P17948	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETProtMapperSIGNORHINTUniProt_LRdbDIPLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDIntActDLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDCellinkerREACH_ProtMapperSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbSparser_ProtMapperHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb	SIGNOR:14704231 BioGRID:35874709 SPIKE_LC:17145710 Cellinker:15637071 connectomeDB2020:9393862 DIP:8631822 IntAct:20660291 Lit-BM-17:8631822 ICELLNET:26285753 HINT:35874709 HINT:8621427 HPRD:9393862 Lit-BM-17:10543948 connectomeDB2020:17051153 Cellinker:8621427 HINT:9393862 Lit-BM-17:21939755 ProtMapper:22348123 DIP:8621427 Lit-BM-17:9393862 HINT:10543948 ProtMapper:27009237 connectomeDB2020:8621427 CellChatDB:16633338 HINT:20660291 HINT:21939755 HPRD:8621427 HPRD:17051153 HINT:28111021 HINT:33961781 LRdb:17051153 LRdb:15637071 CellTalkDB:17051153 IntAct:33961781 IntAct:10543948 Lit-BM-17:8621427 ProtMapper:21441409 connectomeDB2020:15637071 Cellinker:17051153 Cellinker:9393862 LRdb:9393862 LRdb:8621427 IntAct:9393862 HPMR:8356051
PTPRJ	Q12913	VGFR1	P17948	Yes	No	Yes	SIGNORIntAct	IntAct:16893970 SIGNOR:12771128 IntAct:12771128
VGFR1	P17948	LGUL	Q04760	Yes	Yes	No	SIGNOR	SIGNOR:34838714

Protein Complex Composition

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
FLT1_complex	FLT1 KDR	P17948 P35968	1:1	CellPhoneDBCellChatDBICELLNET	CellPhoneDB:FLT1_complex	22828632 11181169 8806634
	FLT1 VEGFA	P15692 P17948	2:2	hu.MAP2PDB	PDB:5t89PDB:1qtyPDB:1flt
	FLT1	P17948	4	PDB	PDB:4cl7PDB:5abd
	FLT1 PGF	P17948 P49763	2:2	PDB	PDB:1rv6
	FLT1 VEGFB	P17948 P49765	2:2	PDB	PDB:2xac
	FLT1 SMYD3	P17948 Q9H7B4	1:1	PDB	PDB:5ex3

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western Blotting	1	37353784

Sequence, Structure & Domains

Sequences

Length

1,338

Mass

150,769

Sequence

MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISAPKFNSGSSDDVRYVNAFKFMSLERIKTFEELLPNATSMFDDYQGDSSTLLASPMLKRFTWTDSKPKASLKIDLRVTSKSKESGLSDVSRPSFCHSSCGHVSEGKRRFTYDHAELERKIACCSPPPDYNSVVLYSTPPI

Alternative Products

Event=Alternative splicing; Named isoforms=8; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Flt1; IsoId=P17948-1; Sequence=Displayed; Name=2; Synonyms=sFlt1; IsoId=P17948-2; Sequence=VSP_002955, VSP_002956; Name=3; Synonyms=sFlt1-14; IsoId=P17948-3; Sequence=VSP_041927, VSP_041928; Name=4; IsoId=P17948-4; Sequence=VSP_041929, VSP_041930; Name=5; Synonyms=i15; IsoId=P17948-5; Sequence=VSP_041985; Name=6; Synonyms=i18; IsoId=P17948-6; Sequence=VSP_041984; Name=7; Synonyms=i21; IsoId=P17948-7; Sequence=VSP_041983; Name=8; IsoId=P17948-8; Sequence=VSP_047759, VSP_047760

Alternative Sequence

1..995; Missing (in isoform 7); 1..875; Missing (in isoform 6); 1..782; Missing (in isoform 5); 1..7; MVSYWDT -> MNSDLLV (in isoform 8); 8..984; Missing (in isoform 8); 518..541; MASTLVVADSRISGIYICIASNKV -> LPPANSSFMLPPTSFSSNYFHFLP (in isoform 4); 542..1338; Missing (in isoform 4); 657..687; DQEAPYLLRNLSDHTVAISSSTTLDCHANGV -> GEHCNKKAVFSRISKFKSTRNDCTTQSNVKH (in isoform 2); 688..1338; Missing (in isoform 2); 706..733; GIILGPGSSTLFIERVTEEDEGVYHCKA -> ELYTSTSPSSSSSSPLSSSSSSSSSSSS (in isoform 3); 734..1338; Missing (in isoform 3)

3D Structural Models

Turn

130..132; 172..174; 188..190; 1015..1017; 1047..1049; 1114..1116

Helix

163..165; 199..201; 806..809; 817..820; 824..826; 849..851; 869..883; 917..922; 996..1014; 1025..1027; 1032..1034; 1042..1044; 1063..1065; 1068..1073; 1078..1093; 1107..1113; 1127..1136; 1141..1143; 1147..1157

Beta Strand

135..137; 140..142; 144..148; 150..152; 154..156; 160..162; 168..171; 175..177; 181..187; 191..196; 203..211; 214..224; 827..835; 837..848; 854..863; 894..898; 906..910; 1028..1030; 1036..1038; 1053..1055

3D Structure

NMR spectroscopy (2); X-ray crystallography (10)

Domain & Motif Annotations

Compositional Bias

940..957; Basic and acidic residues; 959..971; Polar residues

Domain (CC)

The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFA binding.

Domain (FT)

32..123; Ig-like C2-type 1; 151..214; Ig-like C2-type 2; 230..327; Ig-like C2-type 3; 335..421; Ig-like C2-type 4; 428..553; Ig-like C2-type 5; 556..654; Ig-like C2-type 6; 661..747; Ig-like C2-type 7; 827..1158; Protein kinase

Region

940..982; Disordered

Protein Families

Protein kinase superfamily
Tyr protein kinase family
CSF-1/PDGF receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesFDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs

REGORAFENIB NULL LENVATINIB MESYLATE SU-014813 CEP-5214 SUNITINIB GLESATINIB XL820 PTC299 XL999 CENISERTIB NINTEDANIB ESYLATE CEDIRANIB PAZOPANIB VATALANIB SORAFENIB BARASERTIB-HQPA ALISERTIB MOTESANIB FRUQUINTINIB VANDETANIB X-82 TG100-801 GO-6976 MUPARFOSTAT TABERMINOGENE VADENOVEC ENMD-2076 CEP-7055 AST-487 RG-1530 BRIVANIB AXITINIB TIVOZANIB VEGF RECEPTOR TYROSINE KINASE INHIBITOR III BRIVANIB ALANINATE JNJ-7706621 LUCITANIB DOVITINIB FAMITINIB LINIFANIB PD-0166285 VEGFRECINE CEP-11981 SP-600125 ILORASERTIB TELBERMIN FORETINIB CP-547632 TELATINIB AGN-211745 IBCASERTIB TIVOZANIB HYDROCHLORIDE 4SC-203 AEE-788 XL-820 NVP-TAE684 VARGATEF EW-A-401 CYC-116 TESEVATINIB RABEPRAZOLE L-21649 ICRUCUMAB DORAMAPIMOD SEMAXANIB ENTRECTINIB TAMATINIB PEGPLERANIB SODIUM ERLOTINIB KENPAULLONE LENVATINIB AG-13958 CP-459632 OSI-930 TAK-593 TOZASERTIB CHEMBL:CHEMBL1997335 BMS-690514 PF-562271 ABICIPAR PEGOL SULFATINIB ORANTINIB XL-999 GW843682X

Antibody

HPA011740 HPA014290 CAB068189 CAB068190

Interaction Protein

ENSG00000099942ENSG00000112715ENSG00000145675

Interaction Count

Interaction Dataset

intact_biogrid