Protein detail
ITB5
Integrin beta-5
Entry name ITB5 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Integrin beta-5
Protein Class (4)
Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Transmembrane
720..742; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Integrin subunit beta 5
Chromosome
3
Position
124761948-124901418
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificMAIT T-cellBlood Lineage SpecificNK-cells
Function & Pathway8
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Cellular Component (8)
Molecular Function (4)
Biological Process (3)
KEGG (13)
- hsa04145 Phagosome
- KEGG:hsa04148 Efferocytosis
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05205 Proteoglycans in cancer
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Reactome (16)
- R-hsa-1280218 adaptive immune system
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-1236973 cross presentation of particulate exogenous antigens phagosomes
- R-hsa-3000178 ecm proteoglycans
- R-hsa-1566948 elastic fibre formation
- R-hsa-1474244 extracellular matrix organization
- R-hsa-216083 integrin cell surface interactions
- R-hsa-2129379 molecules associated with elastic fibres
- R-hsa-397014 muscle contraction
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Canonical Pathways (3)
- M235 Pid tcr calcium pathway
- M169 Pid integrin2 pathway
- M45 Pid cd40 pathway
Mediation Categories (4)
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence72
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ITGB5 | PAK4 | O96013 | S | 759 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:20507994ProtMapper:28007610ProtMapper:20507994 |
| ITGB5 | PAK4 | O96013 | S | 762 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:20507994ProtMapper:28007610ProtMapper:20507994 |
Ligand-Receptor Signaling (61)
61 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| integrins | receptor | HPMR | No | Yes | No | Yes | No |
| itb_4 | receptor | HPMR | No | Yes | No | Yes | No |
| integrin | receptor | Surfaceome | No | Yes | No | Yes | No |
| cell_adhesion | receptor | ICELLNET | No | Yes | No | Yes | No |
| ecm_interaction | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
Regulatory Interaction Network (4)
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TLN1 | Q9Y490 | ITB5 | P18084 | Yes | Yes | No | CellTalkDBAdhesomeSIGNORReactome_LRdbHPRDInnateDBWangLRdb | Adhesome:12606711SIGNOR:19118207HPRD:12606711CellTalkDB:32196115InnateDB:22025551Adhesome:22025551 |
| PAK4 | O96013 | ITB5 | P18084 | Yes | Yes | No | Sparser_ProtMapperPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperREACH_ProtMapperiPTMnetHPRDHINTRLIMS-P_ProtMapperSIGNOR_ProtMapperLit-BM-17PhosphoSitePhosphoSite_ProtMapperSPIKE_LC | HINT:12356872ProtMapper:28007610ProtMapper:20507994HPRD:12356872SIGNOR:20507994PhosphoSite:20507994Lit-BM-17:12356872SPIKE_LC:16189514 |
| ITBP1 | O14713 | ITB5 | P18084 | Yes | No | Yes | SIGNOR | SIGNOR:19118207 |
| DOK1 | Q99704 | ITB5 | P18084 | Yes | No | Yes | HPRDSIGNOR | HPRD:12606711SIGNOR:19118207 |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| FAK-beta5 integrin complexVEGF induced | ITGB5PTK2 | P18084Q05397 | 1:1 | CompleatCORUM | CORUM:5712Compleat:HC1796 | 12844492 |
| PXN-ITGB5-PTK2 complex | ITGB5PTK2PXN | P18084P49023Q05397 | 1:1:1 | CompleatCORUM | Compleat:HC243CORUM:2726 | 11278329 |
| FAM3AITGB5MFGE8 | P18084P98173Q08431 | 0:0:0 | hu.MAP | |||
| ITGB5MFGE8 | P18084Q08431 | 0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37369038 |
Sequence, Structure & Domains8
Sequences
Length
799
Mass
88,054
Sequence
MPRAPAPLYACLLGLCALLPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEDFGSPRSITSRCDLRANLVKNGCGGEIESPASSFHVLRSLPLSSKGSGSAGWDVIQMTPQEIAVNLRPGDKTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLDNIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILDGDSKNIIQLIINAYNSIRSKVELSVWDQPEDLNLFFTATCQDGVSYPGQRKCEGLKIGDTASFEVSLEARSCPSRHTEHVFALRPVGFRDSLEVGVTYNCTCGCSVGLEPNSARCNGSGTYVCGLCECSPGYLGTRCECQDGENQSVYQNLCREAEGKPLCSGRGDCSCNQCSCFESEFGKIYGPFCECDNFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCRGRDGQICSERGHCLCGQCQCTEPGAFGEMCEKCPTCPDACSTKRDCVECLLLHSGKPDNQTCHSLCRDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFTYVELPSGKSNLTVLREPECGNTPNAMTILLAVVGSILLVGLALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFTFNKFNKSYNGTVD
3D Structural Models
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Domain (CC)
The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.
Domain (FT)
27..76; PSI; 136..378; VWFA; 465..499; I-EGF 1; 500..549; I-EGF 2; 550..586; I-EGF 3; 587..626; I-EGF 4
Protein Families
Integrin beta chain family
Sequence Similarities
Belongs to the integrin beta chain family.
Clinical Relevance6
Disease Involvement
Cancer-related genes
Interaction Protein
ENSG00000138448
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 34265469 | Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer. | Furthermore, utilizing quantitative proteomics approach to reveal the proteomes of CD151-deleted exosomes and cells, we found that exosomal CD151 facilitated secretion of ribosomal proteins via exosomes while inhibiting exosome secretion of complement proteins. Moreover, we proved that CD151-deleted exosomes significantly decreased the migration and invasion of TNBC cells. Most importantly, we found that the tetraspanin CD151 expression levels in TNBC-derived serum exosomes were significantly higher than those exosomes from healthy subjects, and we validated our findings with samples from 16 additional donors. This is the first comparative study of the proteomes of TNBC patient-derived and CD151-deleted exosomes. |