Protein detail
ITB5
Integrin beta-5
Entry name ITB5 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Integrin beta-5
Protein Class
Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Transmembrane
720..742; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Integrin subunit beta 5
Chromosome
3
Position
124761948-124901418
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificMAIT T-cellBlood Lineage SpecificNK-cells
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04145 Phagosome
- KEGG:hsa04148 Efferocytosis
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05410 Hypertrophic cardiomyopathy
- KEGG:hsa05412 Arrhythmogenic right ventricular cardiomyopathy
- KEGG:hsa05414 Dilated cardiomyopathy
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-1236973 cross presentation of particulate exogenous antigens phagosomes
- R-hsa-3000178 ecm proteoglycans
- R-hsa-1566948 elastic fibre formation
- R-hsa-1474244 extracellular matrix organization
- R-hsa-216083 integrin cell surface interactions
- R-hsa-2129379 molecules associated with elastic fibres
- R-hsa-397014 muscle contraction
- R-hsa-3000171 non integrin membrane ecm interactions
- R-hsa-9006936 signaling by tgfb family members
- R-hsa-170834 signaling by tgf beta receptor complex
- R-hsa-445355 smooth muscle contraction
- R-hsa-3000170 syndecan interactions
- R-hsa-2173789 tgf beta receptor signaling activates smads
Canonical Pathways
- M235 Pid tcr calcium pathway
- M169 Pid integrin2 pathway
- M45 Pid cd40 pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ITGB5 | PAK4 | O96013 | S | 759 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:20507994ProtMapper:28007610ProtMapper:20507994 |
| ITGB5 | PAK4 | O96013 | S | 762 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:20507994ProtMapper:28007610ProtMapper:20507994 |
Ligand-Receptor Signaling
61 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ligand | ligand | ICELLNET | Yes | No | No | Yes | No |
| cell_adhesion | ligand | ICELLNET | Yes | No | No | Yes | No |
| cell_adhesion_adhesion_gpcr | ligand | ICELLNET | Yes | No | No | Yes | No |
| ligand | ligand | OmniPath | Yes | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | iTALK | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TLN1 | Q9Y490 | ITB5 | P18084 | Yes | Yes | No | CellTalkDBAdhesomeSIGNORReactome_LRdbHPRDInnateDBWangLRdb | Adhesome:12606711SIGNOR:19118207HPRD:12606711CellTalkDB:32196115InnateDB:22025551Adhesome:22025551 |
| PAK4 | O96013 | ITB5 | P18084 | Yes | Yes | No | Sparser_ProtMapperPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperREACH_ProtMapperiPTMnetHPRDHINTRLIMS-P_ProtMapperSIGNOR_ProtMapperLit-BM-17PhosphoSitePhosphoSite_ProtMapperSPIKE_LC | HINT:12356872ProtMapper:28007610ProtMapper:20507994HPRD:12356872SIGNOR:20507994PhosphoSite:20507994Lit-BM-17:12356872SPIKE_LC:16189514 |
| ITBP1 | O14713 | ITB5 | P18084 | Yes | No | Yes | SIGNOR | SIGNOR:19118207 |
| DOK1 | Q99704 | ITB5 | P18084 | Yes | No | Yes | HPRDSIGNOR | HPRD:12606711SIGNOR:19118207 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| FAK-beta5 integrin complexVEGF induced | ITGB5PTK2 | P18084Q05397 | 1:1 | CompleatCORUM | CORUM:5712Compleat:HC1796 | 12844492 |
| PXN-ITGB5-PTK2 complex | ITGB5PTK2PXN | P18084P49023Q05397 | 1:1:1 | CompleatCORUM | Compleat:HC243CORUM:2726 | 11278329 |
| FAM3AITGB5MFGE8 | P18084P98173Q08431 | 0:0:0 | hu.MAP | |||
| ITGB5MFGE8 | P18084Q08431 | 0:0 | hu.MAP |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37369038 |
Sequence, Structure & Domains
Sequences
Length
799
Mass
88,054
Sequence
MPRAPAPLYACLLGLCALLPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEDFGSPRSITSRCDLRANLVKNGCGGEIESPASSFHVLRSLPLSSKGSGSAGWDVIQMTPQEIAVNLRPGDKTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLDNIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILDGDSKNIIQLIINAYNSIRSKVELSVWDQPEDLNLFFTATCQDGVSYPGQRKCEGLKIGDTASFEVSLEARSCPSRHTEHVFALRPVGFRDSLEVGVTYNCTCGCSVGLEPNSARCNGSGTYVCGLCECSPGYLGTRCECQDGENQSVYQNLCREAEGKPLCSGRGDCSCNQCSCFESEFGKIYGPFCECDNFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCRGRDGQICSERGHCLCGQCQCTEPGAFGEMCEKCPTCPDACSTKRDCVECLLLHSGKPDNQTCHSLCRDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFTYVELPSGKSNLTVLREPECGNTPNAMTILLAVVGSILLVGLALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFTFNKFNKSYNGTVD
3D Structural Models
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Domain (CC)
The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.
Domain (FT)
27..76; PSI; 136..378; VWFA; 465..499; I-EGF 1; 500..549; I-EGF 2; 550..586; I-EGF 3; 587..626; I-EGF 4
Protein Families
Integrin beta chain family
Sequence Similarities
Belongs to the integrin beta chain family.
Clinical Relevance
Disease Involvement
Cancer-related genes
Interaction Protein
ENSG00000138448
Interaction Count
1
Interaction Dataset
intact_biogrid