Protein detail

PTPRA

Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)

Protein symbol PTPRA	UniProt ID P18433	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)

Protein Class

EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Transmembrane

152..174; Helical

Transmembrane Count

Ensembl

ENSG00000132670

Entrez Gene Symbol

PTPRA

Gene Synonym

HLPRHPTPALRPPTPAPTPRL2RPTPA

Gene Description

Protein tyrosine phosphatase receptor type A

Chromosome

Position

2873420-3039076

Frequency

EVMP Score

0.25

Fluorescence & Localization

Cell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway

Protein Function

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Adhesion and uptake mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

9 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PTPRA	PRKCD	Q05655	S	213	phosphorylation	BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSite_ProtMapper	HPRD:11676480 HPRD:11923305 ProtMapper:11676480 ProtMapper:15212693 KEA:11923305 KEA:11676480 SIGNOR:11676480
PTPRA	PRKCD	Q05655	S	189	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper	HPRD:11676480 HPRD:11923305 ProtMapper:11676480 KEA:11923305 HPRD:19651622 KEA:11676480 KEA:17081983 ProtMapper:18809727 SIGNOR:11676480
PTPRA	PRKCD	Q05655	S	180	phosphorylation	HPRDPhosphoSiteKEA	HPRD:11676480 HPRD:11923305 KEA:11923305 HPRD:19651622 KEA:11676480
PTPRA	PRKCD	Q05655	S	204	phosphorylation	Sparser_ProtMapperProtMapperHPRDKEAREACH_ProtMapperPhosphoSite	HPRD:11676480 HPRD:11923305 KEA:11923305 KEA:11676480 ProtMapper:18809727
PTPRA	SRC	P12931	Y	798	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSite_ProtMapper	HPRD:11923305 HPRD:18578522 KEA:7518772 HPRD:7518772 KEA:11923305 HPRD:20068231 HPRD:16497976 ProtMapper:7518772 HPRD:17389395 HPRD:17016520
PTPRA	SRC	P12931	Y	789	phosphorylation	HPRDPhosphoSiteKEA	HPRD:11923305 HPRD:18578522 KEA:7518772 HPRD:7518772 KEA:11923305 HPRD:20068231 HPRD:16497976 HPRD:17389395 HPRD:17016520
PTPRA	LEP	P41159	Y	798	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:30615487
PTPRA	PRKCA	P17252	S	180	phosphorylation	KEA	KEA:7537734 KEA:19144319
PTPRA	PRKCA	P17252	S	204	phosphorylation	KEA	KEA:7537734 KEA:19144319

Ligand-Receptor Signaling

22 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SRC	P12931	PTPRA	P18433	Yes	Yes	Yes	HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAHPRDIntActWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointELMKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteAdhesomeHPRD-phos	HPRD:10698938 IntAct:10698938 ProtMapper:7518772 PhosphoSite:16505154 Adhesome:20158519 HPRD:8647855 Adhesome:10698938 HPRD-phos:11923305 HPRD:12468645 IntAct:11923305 HPRD:11923305 HPRD:9261115 ProtMapper:17016520 HPRD-phos:18578522 PhosphoSite:8670803 HPRD-phos:20068231 ProtMapper:11923305 SIGNOR:7518772 Adhesome:7691597 ProtMapper:17389395 Adhesome:9535845 KEA:7518772 PhosphoSite:16507567 PhosphoSite:10623581 Adhesome:11923305 HINT:11923305 ELM:10698938 HINT:10698938 Adhesome:7518772 HINT:33961781 HPRD:7518772 HPRD-phos:17389395 ProtMapper:18578522 ProtMapper:16497976 KEA:11923305 ProtMapper:20068231 HPRD-phos:16497976 HPRD-phos:7518772 HPRD-phos:17016520
PTPRA	P18433	FYN	P06241	Yes	Yes	Yes	WangAdhesomeSIGNORProtMapperDEPODHPRDCui2007Reactome_ProtMapperCA1SIGNOR_ProtMapperHPRD-phosSPIKE_LC	HPRD:8980254 Adhesome:8980254 CA1:10562275 HPRD-phos:8980254 HPRD:9535845 Adhesome:10562275 Adhesome:8413237 Adhesome:1715582 SIGNOR:17507376 Adhesome:18948260 Adhesome:12682088 Adhesome:9535845 DEPOD:9535845 HPRD-phos:9535845 CA1:9535845 ProtMapper:17507376 HPRD-phos:15588985 ProtMapper:9535845 SPIKE_LC:16713569 SIGNOR:9535845
PTPRA	P18433	SRC	P12931	Yes	Yes	Yes	WangAdhesomeNCI-PID_ProtMapperSIGNORProtMapperDEPODELMCui2007HINTHPRDCA1KEAIntActKinexus_KEASIGNOR_ProtMapperREACH_ProtMapperHPRD-phos	ProtMapper:10698938 HPRD:10698938 ProtMapper:10228160 IntAct:10698938 SIGNOR:10698938 DEPOD:11923305 HPRD-phos:7691597 Adhesome:20158519 HPRD:8647855 Adhesome:10698938 HPRD:12468645 IntAct:11923305 ProtMapper:16227616 HPRD:11923305 HPRD:9261115 HPRD-phos:8647855 ProtMapper:7691597 HPRD-phos:9261115 Adhesome:7691597 HPRD-phos:10787408 Adhesome:9535845 SIGNOR:7691597 HPRD-phos:12468645 Adhesome:11923305 HINT:11923305 ELM:10698938 DEPOD:10698938 HINT:10698938 CA1:9535845 Adhesome:7518772 KEA:10698938 HINT:33961781 HPRD:7518772 ProtMapper:17974954 SIGNOR:17974954 ProtMapper:11238661 HPRD-phos:10698938 HPRD-phos:15588985 ProtMapper:28656243
KPCD	Q05655	PTPRA	P18433	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAHPRDWangPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperHPRD-phos	HPRD-phos:11923305 HPRD:11676480 ProtMapper:18809727 HPRD:11923305 ProtMapper:11676480 ProtMapper:15212693 PhosphoSite:11923305 KEA:11923305 ProtMapper:19651622 HPRD-phos:11676480 KEA:11676480 KEA:17081983 ProtMapper:11923305 HPRD-phos:19651622 PhosphoSite:23532252 PhosphoSite:11676480 SIGNOR:11676480
MARH9	Q86YJ5	PTPRA	P18433	Yes	No	Yes	SIGNOR	SIGNOR:19457934
PTPRA	P18433	VP33B	Q9H267	Yes	No	Yes	SIGNOR	SIGNOR:18474358
PTPRA	P18433	KCNB1	Q14721	Yes	No	Yes	SIGNOR	SIGNOR:16870705
PTPRA	P18433	LYN	P07948	Yes	No	Yes	SIGNOR_ProtMapperSIGNORProtMapperDEPOD	ProtMapper:15537644 SIGNOR:15537644 DEPOD:15537644

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PTPRA homodimer complex	PTPRA	P18433	2	CORUMPDB	CORUM:2005PDB:6uzt	11401727
	DNAJC13 FCN1 FCN2 PTPRA	O00602 O75165 P18433 Q15485	0:0:0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	2	38037300 38576002

Sequence, Structure & Domains

Sequences

Length

802

Mass

90,719

Sequence

MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P18433-5; Sequence=Displayed; Name=2; IsoId=P18433-6; Sequence=VSP_059405

Alternative Sequence

139..147; Missing (in isoform 2)

3D Structural Models

Turn

278..280; 291..294; 478..480; 556..558; 584..587; 681..684; 795..797

Helix

223..225; 226..246; 258..261; 263..268; 318..320; 321..330; 418..430; 447..465; 470..477; 488..504; 511..513; 514..522; 532..541; 547..549; 552..554; 559..561; 571..573; 611..613; 614..623; 707..722; 737..755; 760..770; 778..794

Beta Strand

281..283; 295..301; 310..313; 335..338; 342..344; 356..362; 365..374; 376..387; 398..405; 410..412; 438..441; 443..446; 466..468; 528..531; 574..576; 588..594; 597..599; 603..606; 628..631; 635..637; 649..655; 658..667; 669..680; 685..694; 699..701; 728..731; 733..736; 756..758

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

79..115; Polar residues; 123..141; Polar residues

Domain (FT)

241..501; Tyrosine-protein phosphatase 1; 533..791; Tyrosine-protein phosphatase 2

Region

39..59; Disordered; 79..146; Disordered

Protein Families

Protein-tyrosine phosphatase family
Receptor class 4 subfamily

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.

Clinical Relevance

Antibody

HPA029412 CAB034366 HPA069480

Interaction Protein

ENSG00000146648ENSG00000177885ENSG00000197122

Interaction Count

Interaction Dataset

intact_biogridintact_biogrid_opencell