Protein detail
ITB6
Integrin beta-6
Entry name ITB6 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Integrin beta-6
Protein Class (5)
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins
Protein Function (3)
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Digestive system diseases:Mouth and dental diseases
Transmembrane
710..730; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Integrin subunit beta 6
Chromosome
2
Position
160099667-160200313
Supporting publications (n)
3
EVMP confidence score
0.25
Fluorescence & Localization1
Cell SpecificOocytes
Function & Pathway7
Protein Function (3)
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Digestive system diseases:Mouth and dental diseases
Cellular Component (10)
Molecular Function (4)
Biological Process (3)
KEGG (10)
- hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05410 Hypertrophic cardiomyopathy
- KEGG:hsa05412 Arrhythmogenic right ventricular cardiomyopathy
- KEGG:hsa05414 Dilated cardiomyopathy
Reactome (8)
- R-hsa-3000178 ecm proteoglycans
- R-hsa-1566948 elastic fibre formation
- R-hsa-1474244 extracellular matrix organization
- R-hsa-216083 integrin cell surface interactions
- R-hsa-2129379 molecules associated with elastic fibres
- R-hsa-9006936 signaling by tgfb family members
- R-hsa-170834 signaling by tgf beta receptor complex
- R-hsa-2173789 tgf beta receptor signaling activates smads
Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence67
Ligand-Receptor Signaling (62)
62 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network (4)
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ITB6 | P18564 | TGFB1 | P01137 | Yes | Yes | No | ELMHINTSignaLink3HPRD | ELM:31792290ELM:22278742ELM:28117447SignaLink3:20870411HPRD:10025398ELM:12415008SignaLink3:23331499ELM:31955848ELM:25617764ELM:27033701HINT:28117447ELM:25383667 |
| DOK1 | Q99704 | ITB6 | P18564 | Yes | No | Yes | SIGNOR | SIGNOR:19118207 |
| ITBP1 | O14713 | ITB6 | P18564 | Yes | No | Yes | SIGNOR | SIGNOR:19118207 |
| TLN1 | Q9Y490 | ITB6 | P18564 | Yes | Yes | No | WangSIGNOR | SIGNOR:19118207 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometrySmall R sequencing (Illumi HiSeq 2000 (Solexa) | 16 | 27863537330358143778691838168906394090153481790628986585263789402789410428590090306466163095018538321535400890672914823932089743 |
Sequence, Structure & Domains14
Sequences
Length
788
Mass
85,936
Sequence
MGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKQKVDLSTDC
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P18564-1; Sequence=Displayed; Name=2; IsoId=P18564-2; Sequence=VSP_055189
Alternative Sequence
554..660; Missing (in isoform 2)
3D Structural Models
Turn
24..26; 72..74; 183..185; 196..201; 302..306; 395..397
Helix
31..34; 62..68; 98..100; 143..145; 146..151; 152..154; 155..166; 190..194; 220..229; 242..251; 253..256; 277..283; 312..321; 332..344; 360..371; 455..457
Beta Strand
42..44; 81..86; 108..113; 119..126; 133..140; 170..177; 209..218; 236..241; 262..272; 297..301; 324..330; 349..352; 375..382; 387..393; 399..401; 414..422; 431..437; 444..450; 467..475; 478..481
3D Structure
Electron microscopy (5); X-ray crystallography (8)
Domain & Motif Annotations
Domain (CC)
The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.
Domain (FT)
22..71; PSI; 131..371; VWFA; 456..491; I-EGF 1; 492..538; I-EGF 2; 539..575; I-EGF 3; 576..615; I-EGF 4
Region
731..758; Interaction with HAX1
Protein Families
Integrin beta chain family
Sequence Similarities
Belongs to the integrin beta chain family.
Clinical Relevance6
Disease Involvement (3)
Amelogenesis imperfectaCancer-related genesDisease variant
Related Diseases
Biomarker
Phase 1
Drug Targets (3)
Clinical trial targetSuccessful targetLiterature-reported target
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 25776846 | Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens. | No abstract available |
| 28240915 | Quantitative Proteomic Analysis of Serum Exosomes from Patients with Locally Advanced Pancreatic Cancer Undergoing Chemoradiotherapy. | No abstract available |
| 33017416 | Proteomic analysis of plasma exosomes from Cystic Echinococcosis patients provides in vivo support for distinct immune response profiles in active vs inactive infection and suggests potential biomarkers. | No abstract available |