Protein detail

ADA2C

Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR)

Protein symbol ADA2C	UniProt ID P18825	EVMP score 0.25
Frequency 2	Transmembrane count 7	Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins

Basic Information

Protein Names

Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR)

Protein Class

FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins

Protein Function

FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

49..74; Helical; Name=1; 88..110; Helical; Name=2; 122..147; Helical; Name=3; 168..187; Helical; Name=4; 209..231; Helical; Name=5; 384..408; Helical; Name=6; 417..440; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000184160

Entrez Gene Symbol

ADRA2C

Gene Synonym

ADRA2L2ADRA2RL2ADRARL2

Gene Description

Adrenoceptor alpha 2C

Chromosome

Position

3766348-3768526

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificMonocyte progenitors

Function & Pathway

Protein Function

FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M33 Pid glypican 1pathway
M252 Pid il8 cxcr1 pathway
M76 Pid p38 alpha beta pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

46 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No

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Regulatory Interaction Network

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ADA2C	P18825	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
ADA2C	P18825	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
ADA2C	P18825	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:31160049
ADA2C	P18825	GNAO	P09471	Yes	Yes	No	HPRDSIGNOR	HPRD:1349607 SIGNOR:31160049

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ADRA2C	P18825	2	PDB	PDB:6kuw

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains

Sequences

Length

462

Mass

49,522

Sequence

MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ

3D Structural Models

Helix

48..78; 80..82; 85..87; 88..103; 105..114; 120..154; 156..160; 165..183; 208..218; 220..239; 372..408; 409..412; 416..428; 429..431; 433..440; 442..452

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

294..308; Basic residues; 311..325; Gly residues

Region

246..347; Disordered

Protein Families

G-protein coupled receptor 1 family
Adrenergic receptor subfamily
ADRA2C sub-subfamily

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.

Clinical Relevance

Disease Involvement

FDA approved drug targets

Biomarker

Discontinued in Phase 2; Phase 2; Terminated; Phase 3; Preclinical; Investigative; Discontinued in Phase 3; Approved; Discontinued in Preregistration; Phase 4

Drug Targets

FDA approved drug targets

Drugs

TETRAHYDROZOLINE HYDROCHLORIDE NAPHAZOLINE HYDROCHLORIDE VASOACTIVE INTESTINAL PEPTIDE AMOSULALOL AJMALICINE LOFEXIDINE NULL PROPYLHEXEDRINE TETRAHYDROZOLINE EPINEPHRINE BITARTRATE LOFEXIDINE HYDROCHLORIDE FIPAMEZOLE MEDETOMIDINE MIRTAZAPINE NOREPINEPHRINE SENREBOTASE OLANZAPINE RILMENIDINE ESMIRTAZAPINE MALEATE CLONIDINE HYDROCHLORIDE APRACLONIDINE HYDROCHLORIDE IDAZOXAN DOPAMINE MOXISYLYTE XYLOMETAZOLINE DEBRISOQUIN YOHIMBINE FENOLDOPAM MESYLATE DIHYDROERGOCRISTINE TIZANIDINE HYDROCHLORIDE BETA-ALANINE RAUWOLFIA SERPENTINA (USP)FADOLMIDINE LEVONORDEFRIN ERGOLOID MESYLATES, USP METHAMPHETAMINE EPHEDRINE ERGOTAMINE TARTRATE GUANFACINE HYDROCHLORIDE EPHEDRINE HYDROCHLORIDE BUCINDOLOL HYDROCHLORIDE BETHANIDINE METHYLDOPA ANHYDROUS ISOPROTERENOL BRIMONIDINE ORM-12741 AMEZINIUM PHENTOLAMINE MESYLATE ASENAPINE EPINEPHRINE LABETALOL HYDROCHLORIDE FADOLMIDINE HYDROCHLORIDE CELIPROLOL DEXMEDETOMIDINE HYDROCHLORIDE PHENOXYBENZAMINE HYDROCHLORIDE MOXONIDINE GUANABENZ ACETATE NOREPINEPHRINE BITARTRATE ILOPERIDONE DROXIDOPA OPC-28326 MEPHENTERMINE SULFATE TETRASUL METHYLDOPATE HYDROCHLORIDE OXYMETAZOLINE HYDROCHLORIDE DIPIVEFRIN HYDROCHLORIDE METOPROLOL IDAZOXAN HYDROCHLORIDE TOLAZOLINE HYDROCHLORIDE HYDROXYAMPHETAMINE HYDROBROMIDE LURASIDONE HYDROCHLORIDE CYCLOBENZAPRINE

Antibody

HPA057688