Protein detail
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Entry name PLCG1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 9 | Transmembrane count | Protein classification Cancer-related genesEnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsRAS pathway related proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Protein Class (6)
Cancer-related genesEnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsRAS pathway related proteins
Protein Function (5)
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- RAS pathway related proteins
- Enzymes
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
NCKAP3PLC-IIPLC1PLC148PLCgamma1
Gene Description
Phospholipase C gamma 1
Chromosome
20
Position
41136960-41196801
Supporting publications (n)
9
EVMP confidence score
0.50
Fluorescence & Localization1
Function & Pathway7
Protein Function (5)
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- RAS pathway related proteins
- Enzymes
- ENZYME proteins:Hydrolases
Cellular Component (11)
- GO:0001726 ruffle
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0008180 COP9 signalosome
- GO:0030027 lamellipodium
- GO:0032587 ruffle membrane
- GO:0042995 cell projection
- GO:0098685 Schaffer collateral - CA1 synapse
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Molecular Function (10)
- GO:0004435 phosphatidylinositol phospholipase C activity
- GO:0004629 phospholipase C activity
- GO:0005085 guanyl-nucleotide exchange factor activity
- GO:0005168 neurotrophin TRKA receptor binding
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0019901 protein kinase binding
- GO:0030971 receptor tyrosine kinase binding
- GO:0035254 glutamate receptor binding
- GO:0050429 calcium-dependent phospholipase C activity
Biological Process (3)
KEGG (46)
- hsa00562 Inositol phosphate metabolism
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa01521 EGFR tyrosine kinase inhibitor resistance
- KEGG:hsa04012 ErbB signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04064 NF-kappa B signaling pathway
- KEGG:hsa04066 HIF-1 signaling pathway
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Reactome (67)
- R-hsa-1280218 adaptive immune system
- R-hsa-1169410 antimicrobial mechanism of ifn stimulated genes
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-5637810 constitutive signaling by egfrviii
- R-hsa-1236382 constitutive signaling by ligand responsive egfr cancer variants
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-1489509 dag and ip3 signaling
- R-hsa-2172127 dap12 interactions
- R-hsa-2424491 dap12 signaling
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Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence141
Enzyme-Mediated Modification (83)
83 records.
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network (47)
47 records.
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| SLP-76-PLC-gamma-1-ITK complexalpha-TCR stimulated | ITKLCP2PLCG1 | P19174Q08881Q13094 | 1:1:1 | CompleatCORUM | CORUM:2960Compleat:HC1831 | 17148460 |
| SLP-76-PLC-gamma-1-VAV complexalpha-TCR stimulated | LCP2PLCG1VAV1 | P15498P19174Q13094 | 1:1:1 | CompleatCORUM | CORUM:2961Compleat:HC1206 | 17148460 |
| HRASPDSS2PIK3R1PLCG1RALGDSRAPGEF1RRASRRAS2SOS1SOS2 | P01112P10301P19174P27986P62070Q07889Q07890Q12967Q13905Q86YH6 | 1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6464 | ||
| PLCG1 | P19174 | 4 | PDB | PDB:4ey0 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains12
Sequences
Length
1,290
Mass
148,532
Sequence
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P19174-1; Sequence=Displayed; Name=2; IsoId=P19174-2; Sequence=VSP_038692
Alternative Sequence
1215; K -> KQ (in isoform 2)
3D Structural Models
Turn
825..827; 843..845
Helix
561..576; 615..617; 632..641; 662..665; 675..683; 734..741; 758..764
Beta Strand
551..554; 556..558; 583..587; 589..591; 595..601; 604..612; 621..624; 628..631; 644..646; 649..651; 669..672; 690..695; 701..708; 711..720; 723..726; 729..733; 792..794; 805..809; 817..820; 834..836
3D Structure
NMR spectroscopy (2); X-ray crystallography (3)
Domain & Motif Annotations
Domain (CC)
The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1 (PubMed:10747847).
Domain (FT)
27..142; PH 1; 152..187; EF-hand; 320..464; PI-PLC X-box; 489..523; PH 2; first part; 550..657; SH2 1; 668..756; SH2 2; 791..851; SH3; 895..931; PH 2; second part; 953..1070; PI-PLC Y-box; 1071..1194; C2
Region
522..544; Disordered; 1271..1290; Disordered
Clinical Relevance6
Disease Involvement (2)
Cancer-related genesDisease variant
Drugs (9)
Interaction Protein (11)
ENSG00000043462ENSG00000077782ENSG00000100485ENSG00000113721ENSG00000115904ENSG00000121774ENSG00000142208ENSG00000146648ENSG00000157404ENSG00000177885ENSG00000213658
Interaction Count
11
Interaction Dataset
intact_biogrid
Supporting Publications8
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 36398564 | Differential ultracentrifugation enables deep plasma proteomics through enrichment of extracellular vesicles. | No abstract available |
| 36797805 | Magnetic transferrin nanoparticles (MTNs) assay as a novel isolation approach for exosomal biomarkers in neurological diseases. | No abstract available |
| 39766158 | A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis. | No abstract available |
| 39940641 | Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients. | No abstract available |