Protein detail
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Protein symbol PLCG1 | UniProt ID | EVMP score 0.50 |
Frequency 9 | Transmembrane count | Protein classification Cancer-related genesEnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsRAS pathway related proteins |
Basic Information
Protein Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Protein Class
Cancer-related genesEnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsRAS pathway related proteins
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- RAS pathway related proteins
- Enzymes
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym
NCKAP3PLC-IIPLC1PLC148PLCgamma1
Gene Description
Phospholipase C gamma 1
Chromosome
20
Position
41136960-41196801
Frequency
9
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- RAS pathway related proteins
- Enzymes
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
- GO:0004435 phosphatidylinositol phospholipase C activity
- GO:0004629 phospholipase C activity
- GO:0005085 guanyl-nucleotide exchange factor activity
- GO:0005168 neurotrophin TRKA receptor binding
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0019901 protein kinase binding
- GO:0030971 receptor tyrosine kinase binding
- GO:0035254 glutamate receptor binding
- GO:0050429 calcium-dependent phospholipase C activity
Biological Process
KEGG
- hsa00562 Inositol phosphate metabolism
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa01521 EGFR tyrosine kinase inhibitor resistance
- KEGG:hsa04012 ErbB signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04064 NF-kappa B signaling pathway
- KEGG:hsa04066 HIF-1 signaling pathway
- KEGG:hsa04070 Phosphatidylinositol signaling system
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04360 Axon guidance
- KEGG:hsa04370 VEGF signaling pathway
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04650 Natural killer cell mediated cytotoxicity
- KEGG:hsa04658 Th1 and Th2 cell differentiation
- KEGG:hsa04659 Th17 cell differentiation
- KEGG:hsa04660 T cell receptor signaling pathway
- KEGG:hsa04664 Fc epsilon RI signaling pathway
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa04670 Leukocyte transendothelial migration
- KEGG:hsa04722 Neurotrophin signaling pathway
- KEGG:hsa04750 Inflammatory mediator regulation of TRP channels
- KEGG:hsa04919 Thyroid hormone signaling pathway
- KEGG:hsa04933 AGE-RAGE signaling pathway in diabetic complications
- KEGG:hsa04935 Growth hormone synthesis, secretion and action
- KEGG:hsa05012 Parkinson disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05110 Vibrio cholerae infection
- KEGG:hsa05120 Epithelial cell signaling in Helicobacter pylori infection
- KEGG:hsa05131 Shigellosis
- KEGG:hsa05135 Yersinia infection
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
- KEGG:hsa05171 Coronavirus disease
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05206 MicroRNAs in cancer
- KEGG:hsa05214 Glioma
- KEGG:hsa05223 Non-small cell lung cancer
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05231 Choline metabolism in cancer
- KEGG:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
- KEGG:hsa05417 Lipid and atherosclerosis
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-1169410 antimicrobial mechanism of ifn stimulated genes
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-5637810 constitutive signaling by egfrviii
- R-hsa-1236382 constitutive signaling by ligand responsive egfr cancer variants
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-1489509 dag and ip3 signaling
- R-hsa-2172127 dap12 interactions
- R-hsa-2424491 dap12 signaling
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-5654687 downstream signaling of activated fgfr1
- R-hsa-5654696 downstream signaling of activated fgfr2
- R-hsa-5654708 downstream signaling of activated fgfr3
- R-hsa-5654716 downstream signaling of activated fgfr4
- R-hsa-186763 downstream signal transduction
- R-hsa-212718 egfr interacts with phospholipase c gamma
- R-hsa-9027277 erythropoietin activates phospholipase c gamma plcg
- R-hsa-2871809 fceri mediated ca 2 mobilization
- R-hsa-2871796 fceri mediated mapk activation
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-9664323 fcgr3a mediated il10 synthesis
- R-hsa-2454202 fc epsilon receptor fceri signaling
- R-hsa-202433 generation of second messenger molecules
- R-hsa-109582 hemostasis
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-1483249 inositol phosphate metabolism
- R-hsa-913531 interferon signaling
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-1169408 isg15 antiviral mechanism
- R-hsa-9658195 leishmania infection
- R-hsa-9675108 nervous system development
- R-hsa-373752 netrin 1 signaling
- R-hsa-210990 pecam1 interactions
- R-hsa-5654219 phospholipase c mediated cascade fgfr1
- R-hsa-5654221 phospholipase c mediated cascade fgfr2
- R-hsa-5654228 phospholipase c mediated cascade fgfr4
- R-hsa-8853659 ret signaling
- R-hsa-2029485 role of phospholipids in phagocytosis
- R-hsa-418890 role of second messengers in netrin 1 signaling
- R-hsa-201556 signaling by alk
- R-hsa-9700206 signaling by alk in cancer
- R-hsa-177929 signaling by egfr
- R-hsa-1643713 signaling by egfr in cancer
- R-hsa-1227986 signaling by erbb2
- R-hsa-9665348 signaling by erbb2 ecd mutants
- R-hsa-1227990 signaling by erbb2 in cancer
- R-hsa-9006335 signaling by erythropoietin
- R-hsa-190236 signaling by fgfr
- R-hsa-5654736 signaling by fgfr1
- R-hsa-5655302 signaling by fgfr1 in disease
- R-hsa-5654738 signaling by fgfr2
- R-hsa-5655253 signaling by fgfr2 in disease
- R-hsa-5654741 signaling by fgfr3
- R-hsa-5654743 signaling by fgfr4
- R-hsa-5655291 signaling by fgfr4 in disease
- R-hsa-1226099 signaling by fgfr in disease
- R-hsa-9006115 signaling by ntrk2 trkb
- R-hsa-9034015 signaling by ntrk3 trkc
- R-hsa-166520 signaling by ntrks
- R-hsa-186797 signaling by pdgf
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-194138 signaling by vegf
- R-hsa-1855204 synthesis of ip3 and ip4 in the cytosol
- R-hsa-202403 tcr signaling
- R-hsa-5218921 vegfr2 mediated cell proliferation
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
83 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PLCG1 | AKT1 | P31749 | S | 1,248 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| PLCG1 | AKT1 | P31749 | S | 1,249 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PLCG1 | PRKX | P51817 | S | 1,249 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PLCG1 | PRKY | O43930 | S | 1,249 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PLCG1 | BTK | Q06187 | Y | 783 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:9550384ProtMapper:15010370 |
| PLCG1 | BTK | Q06187 | Y | 1,253 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:9550384ProtMapper:15010370 |
| PLCG1 | VAV1 | P15498 | Y | 783 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:9550384ProtMapper:15010370 |
| PLCG1 | VAV1 | P15498 | Y | 1,253 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:9550384ProtMapper:15010370 |
| PLCG1 | ROS1 | P08922 | Y | 783 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:29388468 |
| PLCG1 | EGF | P01133 | Y | 783 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:23613900ProtMapper:16525023 |
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
47 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| SLP-76-PLC-gamma-1-ITK complexalpha-TCR stimulated | ITKLCP2PLCG1 | P19174Q08881Q13094 | 1:1:1 | CompleatCORUM | CORUM:2960Compleat:HC1831 | 17148460 |
| SLP-76-PLC-gamma-1-VAV complexalpha-TCR stimulated | LCP2PLCG1VAV1 | P15498P19174Q13094 | 1:1:1 | CompleatCORUM | CORUM:2961Compleat:HC1206 | 17148460 |
| HRASPDSS2PIK3R1PLCG1RALGDSRAPGEF1RRASRRAS2SOS1SOS2 | P01112P10301P19174P27986P62070Q07889Q07890Q12967Q13905Q86YH6 | 1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6464 | ||
| PLCG1 | P19174 | 4 | PDB | PDB:4ey0 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,290
Mass
148,532
Sequence
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P19174-1; Sequence=Displayed; Name=2; IsoId=P19174-2; Sequence=VSP_038692
Alternative Sequence
1215; K -> KQ (in isoform 2)
3D Structural Models
Turn
825..827; 843..845
Helix
561..576; 615..617; 632..641; 662..665; 675..683; 734..741; 758..764
Beta Strand
551..554; 556..558; 583..587; 589..591; 595..601; 604..612; 621..624; 628..631; 644..646; 649..651; 669..672; 690..695; 701..708; 711..720; 723..726; 729..733; 792..794; 805..809; 817..820; 834..836
3D Structure
NMR spectroscopy (2); X-ray crystallography (3)
Domain & Motif Annotations
Domain (CC)
The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1 (PubMed:10747847).
Domain (FT)
27..142; PH 1; 152..187; EF-hand; 320..464; PI-PLC X-box; 489..523; PH 2; first part; 550..657; SH2 1; 668..756; SH2 2; 791..851; SH3; 895..931; PH 2; second part; 953..1070; PI-PLC Y-box; 1071..1194; C2
Region
522..544; Disordered; 1271..1290; Disordered
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variant
Drugs
Interaction Protein
ENSG00000043462ENSG00000077782ENSG00000100485ENSG00000113721ENSG00000115904ENSG00000121774ENSG00000142208ENSG00000146648ENSG00000157404ENSG00000177885ENSG00000213658
Interaction Count
11
Interaction Dataset
intact_biogrid