Protein detail

EPOR

Erythropoietin receptor (EPO-R)

Protein symbol EPOR	UniProt ID P19235	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Erythropoietin receptor (EPO-R)

Protein Function

Disease related genes
Cancer-related genes:Candidate cancer biomarkers
Human disease related genes:Cardiovascular diseases:Hematologic diseases
FDA approved drug targets:Biotech drugs

Transmembrane

251..273; Helical

Transmembrane Count

Ensembl

ENSG00000187266

Entrez Gene Symbol

EPOR

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificblood vesselCell SpecificAdrenal medulla cells

Function & Pathway

Protein Function

Disease related genes
Cancer-related genes:Candidate cancer biomarkers
Human disease related genes:Cardiovascular diseases:Hematologic diseases
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

15 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
EPOR	JAK1	P23458	Y	489	phosphorylation	Li2012
EPOR	JAK1	P23458	Y	426	phosphorylation	Li2012
EPOR	JAK1	P23458	Y	454	phosphorylation	Li2012
EPOR	JAK1	P23458	Y	456	phosphorylation	Li2012
EPOR	INSR	P06213	Y	489	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling

72 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	Yes	Yes	No
intracellular	intracellular	OmniPath	No	No	Yes	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	Yes	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	Yes	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	Yes	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	Yes	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	Yes	Yes	No

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Regulatory Interaction Network

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
JAK2	O60674	EPOR	P19235	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDCui2007WangBEL-Large-Corpus_ProtMapperHPRD-phosphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEABioGRIDHPRD_KEAphosphoELMCellinkerSIGNOR_ProtMapperSPIKE_LCSPIKE	HPRD:8343951 Cellinker:9030561 HPRD:11779507 ProtMapper:12441334 KEA:12441334 SPIKE:18672044 KEA:9573010 SIGNOR:12441334 KEA:10660611 ProtMapper:15212693 HINT:30044226 KEA:7559499 KEA:11443118 HINT:8343951 KEA:10579919 phosphoELM:10579919 HPRD:12441334 SPIKE:12524467 SPIKE_LC:18672044 HINT:11779507 BioGRID:8343951 HPRD-phos:12441334 SPIKE_LC:12524467 KEA:12027890
EPOR	P19235	JAK2	O60674	Yes	Yes	No	KEGG-MEDICUSHPRDCui2007HINTSignaLink3BioGRIDWang	HPRD:12441334 HPRD:8343951 HINT:8343951 HINT:30044226 HPRD:11779507 HINT:11779507 BioGRID:8343951 SignaLink3:23331499 SignaLink3:8343951 SignaLink3:18160720 SignaLink3:11779507
EPO	P01588	EPOR	P19235	Yes	Yes	No	iTALKKirouac2010KEGG-MEDICUSGuide2Pharma_LRdbICELLNETSIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007IntActDLRP_talklrRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	HINT:9774108 IntAct:29997244 Lit-BM-17:15358619 SPIKE_LC:17145710 SIGNOR:9442088 ICELLNET:9974393 LRdb:10318834 IntAct:9774108 Cellinker:10318834 Lit-BM-17:8662939 Cellinker:16982323 DIP:8662939 Lit-BM-17:17327410 LRdb:9442088 Lit-BM-17:10318834 Lit-BM-17:9808045 BioGRID:9808045 BioGRID:17327410 LRdb:16982323 HINT:9808045 connectomeDB2020:9808045 Lit-BM-17:9774108 HPMR:9442088 DIP:9774108 HPRD:10318834 Lit-BM-17:9030560 Guide2Pharma:16982323 Baccin2019:9442088 Baccin2019:16982323 connectomeDB2020:16982323 HINT:15358619 InnateDB:9774108 SignaLink3:9774108 SignaLink3:23331499 DIP:9030560 connectomeDB2020:9442088 Cellinker:9442088 BioGRID:15358619 ICELLNET:2163696 scConnect:16982323 SPIKE_LC:18586265 Baccin2019:10318834 InnateDB:21889455 HINT:29997244 LRdb:9808045 SPIKE:18586265 Cellinker:9808045 HINT:10318834 SIGNOR:9774108 HPRD:9808045 Baccin2019:9808045 BioGRID:10318834 connectomeDB2020:10318834 DIP:10318834
EPOR	P19235	P85A	P27986	Yes	Yes	No	HPRDHINTSignaLink3SPIKE_LCLit-BM-17	SignaLink3:7559499 Lit-BM-17:7559499 HINT:7559499 Lit-BM-17:15644415 Lit-BM-17:9162069 Lit-BM-17:24113870 HPRD:7559499 SPIKE_LC:16713569 SignaLink3:23331499 HINT:15644415 SignaLink3:9162069
NOSIP	Q9Y314	EPOR	P19235	Yes	Yes	No	SIGNOR	SIGNOR:12746455
PTN1	P18031	EPOR	P19235	Yes	No	Yes	SPIKE_LCSIGNORIntActDEPOD	SPIKE_LC:14527337 IntAct:14527337 SIGNOR:14527337 DEPOD:14527337

Protein Complex Composition

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
EPO-EPOR complex	EPO EPOR	P01588 P19235	1:2	CORUMCompleathu.MAP2SPIKEPDB	CORUM:5446PDB:1eerCompleat:HC779PDB:1cn4	9774108
EPOR receptor complex	EPOR	P19235	2	CORUMPDB	PDB:6mohPDB:1ernPDB:1ebaPDB:4y5vPDB:1ebpPDB:6molPDB:4y5yPDB:6moeCORUM:5442	8662530
Epo-R-IP(3)R type II-TRPC2 complex	EPOR ITPR1 ITPR2	P19235 Q14571 Q14643	1:1:1	Compleat	Compleat:HC440	15329338
	EPOR JAK2	O60674 P19235	4:4	PDB	PDB:6e2q
	EPOR Q5NV67	P19235 Q5NV67	4:4	PDB	PDB:4y5x
	EPOR Q6GMX6 Q7Z3Y4	P19235 Q6GMX6 Q7Z3Y4	3:3:3	PDB	PDB:2jix

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	8	36406491 39949490 38225453 32795414 38731868 27333275 40344445 40311616

Sequence, Structure & Domains

Sequences

Length

508

Mass

55,065

Sequence

MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=EPOR-F; Synonyms=Full-length form; IsoId=P19235-1; Sequence=Displayed; Name=EPOR-S; Synonyms=Soluble form; IsoId=P19235-2; Sequence=VSP_009508, VSP_009509; Name=EPOR-T; Synonyms=Truncated form; IsoId=P19235-3; Sequence=VSP_009510, VSP_009511

Alternative Sequence

196..241; VEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVS -> GTVFLSPDWLSSTRARPHVIYFCLLRVPRPDSAPRWRSWRAAPSVC (in isoform EPOR-S); 242..508; Missing (in isoform EPOR-S); 306..328; LWLYQNDGCLWWSPCTPFTEDPP -> VGGLVVPSVPGLPCFLQPNCRPL (in isoform EPOR-T); 329..508; Missing (in isoform EPOR-T)

3D Structural Models

Turn

99..101; 127..129; 226..228; 245..247; 294..299

Helix

33..45; 111..113; 139..141; 175..177; 250..282; 289..293; 304..311

Beta Strand

47..49; 51..58; 61..67; 76..83; 84..86; 89..91; 93..98; 102..108; 116..118; 120..126; 131..137; 142..144; 149..155; 157..160; 162..167; 169..171; 178..185; 188..190; 195..198; 204..207; 212..224; 240..244; 316..320

3D Structure

NMR spectroscopy (1); X-ray crystallography (21)

Domain & Motif Annotations

Motif

233..237; WSXWS motif; 282..290; Box 1 motif; 452..457; ITIM motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.; DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Domain (FT)

147..247; Fibronectin type-III

Region

454..456; Required for high-affinity SOCS3 binding; 467..494; Disordered

Protein Families

Type I cytokine receptor family
Type 1 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 1 subfamily.

Clinical Relevance

Related Diseases

Anemia Depression General pain disorder Neuropathy Retinopathy Sarcoidosis Solid tumour/cancer Transplant rejection

Biomarker

Approved; Phase 2; Phase 1

Drugs

EPOETIN ALFA NULL METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA CIBINETIDE EPOETIN DELTA EPOETIN THETA EFEPOETIN ALFA PEGINESATIDE CAPSAICIN PEGINESATIDE ACETATE ERYTHROPOIESIS-STIMULATING AGENT

Interaction Protein

ENSG00000111679ENSG00000130427

Interaction Count

Interaction Dataset

intact_biogrid