Protein detail

EPOR

Erythropoietin receptor (EPO-R)

Protein symbol EPOR	UniProt ID P19235	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Erythropoietin receptor (EPO-R)

Protein Function

Disease related genes
Cancer-related genes:Candidate cancer biomarkers
Human disease related genes:Cardiovascular diseases:Hematologic diseases
FDA approved drug targets:Biotech drugs

Transmembrane

251..273; Helical

Transmembrane Count

Ensembl

ENSG00000187266

Entrez Gene Symbol

EPOR

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificblood vesselCell SpecificAdrenal medulla cells

Function & Pathway

Protein Function

Disease related genes
Cancer-related genes:Candidate cancer biomarkers
Human disease related genes:Cardiovascular diseases:Hematologic diseases
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

15 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
EPOR	JAK1	P23458	Y	489	phosphorylation	Li2012
EPOR	JAK1	P23458	Y	426	phosphorylation	Li2012
EPOR	JAK1	P23458	Y	454	phosphorylation	Li2012
EPOR	JAK1	P23458	Y	456	phosphorylation	Li2012
EPOR	INSR	P06213	Y	489	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling

72 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	Yes	Yes	No
receptor	receptor	GO_Intercell	No	Yes	Yes	Yes	No
receptor	receptor	HPMR	No	Yes	Yes	Yes	No
receptor	receptor	ICELLNET	No	Yes	Yes	Yes	No
receptor	receptor	CellChatDB	No	Yes	Yes	Yes	No
receptor	receptor	CellTalkDB	No	Yes	Yes	Yes	No
receptor	receptor	Surfaceome	No	Yes	Yes	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	Yes	Yes	No
receptor	receptor	Kirouac2010	No	Yes	Yes	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	Yes	Yes	No

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Regulatory Interaction Network

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
JAK2	O60674	EPOR	P19235	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDCui2007WangBEL-Large-Corpus_ProtMapperHPRD-phosphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEABioGRIDHPRD_KEAphosphoELMCellinkerSIGNOR_ProtMapperSPIKE_LCSPIKE	HPRD:8343951 Cellinker:9030561 HPRD:11779507 ProtMapper:12441334 KEA:12441334 SPIKE:18672044 KEA:9573010 SIGNOR:12441334 KEA:10660611 ProtMapper:15212693 HINT:30044226 KEA:7559499 KEA:11443118 HINT:8343951 KEA:10579919 phosphoELM:10579919 HPRD:12441334 SPIKE:12524467 SPIKE_LC:18672044 HINT:11779507 BioGRID:8343951 HPRD-phos:12441334 SPIKE_LC:12524467 KEA:12027890
EPOR	P19235	JAK2	O60674	Yes	Yes	No	KEGG-MEDICUSHPRDCui2007HINTSignaLink3BioGRIDWang	HPRD:12441334 HPRD:8343951 HINT:8343951 HINT:30044226 HPRD:11779507 HINT:11779507 BioGRID:8343951 SignaLink3:23331499 SignaLink3:8343951 SignaLink3:18160720 SignaLink3:11779507
EPO	P01588	EPOR	P19235	Yes	Yes	No	iTALKKirouac2010KEGG-MEDICUSGuide2Pharma_LRdbICELLNETSIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007IntActDLRP_talklrRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	HINT:9774108 IntAct:29997244 Lit-BM-17:15358619 SPIKE_LC:17145710 SIGNOR:9442088 ICELLNET:9974393 LRdb:10318834 IntAct:9774108 Cellinker:10318834 Lit-BM-17:8662939 Cellinker:16982323 DIP:8662939 Lit-BM-17:17327410 LRdb:9442088 Lit-BM-17:10318834 Lit-BM-17:9808045 BioGRID:9808045 BioGRID:17327410 LRdb:16982323 HINT:9808045 connectomeDB2020:9808045 Lit-BM-17:9774108 HPMR:9442088 DIP:9774108 HPRD:10318834 Lit-BM-17:9030560 Guide2Pharma:16982323 Baccin2019:9442088 Baccin2019:16982323 connectomeDB2020:16982323 HINT:15358619 InnateDB:9774108 SignaLink3:9774108 SignaLink3:23331499 DIP:9030560 connectomeDB2020:9442088 Cellinker:9442088 BioGRID:15358619 ICELLNET:2163696 scConnect:16982323 SPIKE_LC:18586265 Baccin2019:10318834 InnateDB:21889455 HINT:29997244 LRdb:9808045 SPIKE:18586265 Cellinker:9808045 HINT:10318834 SIGNOR:9774108 HPRD:9808045 Baccin2019:9808045 BioGRID:10318834 connectomeDB2020:10318834 DIP:10318834
EPOR	P19235	P85A	P27986	Yes	Yes	No	HPRDHINTSignaLink3SPIKE_LCLit-BM-17	SignaLink3:7559499 Lit-BM-17:7559499 HINT:7559499 Lit-BM-17:15644415 Lit-BM-17:9162069 Lit-BM-17:24113870 HPRD:7559499 SPIKE_LC:16713569 SignaLink3:23331499 HINT:15644415 SignaLink3:9162069
NOSIP	Q9Y314	EPOR	P19235	Yes	Yes	No	SIGNOR	SIGNOR:12746455
PTN1	P18031	EPOR	P19235	Yes	No	Yes	SPIKE_LCSIGNORIntActDEPOD	SPIKE_LC:14527337 IntAct:14527337 SIGNOR:14527337 DEPOD:14527337

Protein Complex Composition

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
EPO-EPOR complex	EPO EPOR	P01588 P19235	1:2	CORUMCompleathu.MAP2SPIKEPDB	CORUM:5446PDB:1eerCompleat:HC779PDB:1cn4	9774108
EPOR receptor complex	EPOR	P19235	2	CORUMPDB	PDB:6mohPDB:1ernPDB:1ebaPDB:4y5vPDB:1ebpPDB:6molPDB:4y5yPDB:6moeCORUM:5442	8662530
Epo-R-IP(3)R type II-TRPC2 complex	EPOR ITPR1 ITPR2	P19235 Q14571 Q14643	1:1:1	Compleat	Compleat:HC440	15329338
	EPOR JAK2	O60674 P19235	4:4	PDB	PDB:6e2q
	EPOR Q5NV67	P19235 Q5NV67	4:4	PDB	PDB:4y5x
	EPOR Q6GMX6 Q7Z3Y4	P19235 Q6GMX6 Q7Z3Y4	3:3:3	PDB	PDB:2jix

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	8	36406491 39949490 38225453 32795414 38731868 27333275 40344445 40311616

Sequence, Structure & Domains

Sequences

Length

508

Mass

55,065

Sequence

MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=EPOR-F; Synonyms=Full-length form; IsoId=P19235-1; Sequence=Displayed; Name=EPOR-S; Synonyms=Soluble form; IsoId=P19235-2; Sequence=VSP_009508, VSP_009509; Name=EPOR-T; Synonyms=Truncated form; IsoId=P19235-3; Sequence=VSP_009510, VSP_009511

Alternative Sequence

196..241; VEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVS -> GTVFLSPDWLSSTRARPHVIYFCLLRVPRPDSAPRWRSWRAAPSVC (in isoform EPOR-S); 242..508; Missing (in isoform EPOR-S); 306..328; LWLYQNDGCLWWSPCTPFTEDPP -> VGGLVVPSVPGLPCFLQPNCRPL (in isoform EPOR-T); 329..508; Missing (in isoform EPOR-T)

3D Structural Models

Turn

99..101; 127..129; 226..228; 245..247; 294..299

Helix

33..45; 111..113; 139..141; 175..177; 250..282; 289..293; 304..311

Beta Strand

47..49; 51..58; 61..67; 76..83; 84..86; 89..91; 93..98; 102..108; 116..118; 120..126; 131..137; 142..144; 149..155; 157..160; 162..167; 169..171; 178..185; 188..190; 195..198; 204..207; 212..224; 240..244; 316..320

3D Structure

NMR spectroscopy (1); X-ray crystallography (21)

Domain & Motif Annotations

Motif

233..237; WSXWS motif; 282..290; Box 1 motif; 452..457; ITIM motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.; DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Domain (FT)

147..247; Fibronectin type-III

Region

454..456; Required for high-affinity SOCS3 binding; 467..494; Disordered

Protein Families

Type I cytokine receptor family
Type 1 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 1 subfamily.

Clinical Relevance

Related Diseases

Anemia Depression General pain disorder Neuropathy Retinopathy Sarcoidosis Solid tumour/cancer Transplant rejection

Biomarker

Approved; Phase 2; Phase 1

Drugs

EPOETIN ALFA NULL METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA CIBINETIDE EPOETIN DELTA EPOETIN THETA EFEPOETIN ALFA PEGINESATIDE CAPSAICIN PEGINESATIDE ACETATE ERYTHROPOIESIS-STIMULATING AGENT

Interaction Protein

ENSG00000111679ENSG00000130427

Interaction Count

Interaction Dataset

intact_biogrid