Protein detail
ELAF
Elafin (Elastase-specific inhibitor) (ESI) (Peptidase inhibitor 3) (PI-3) (Protease inhibitor WAP3) (Skin-derived antileukoproteinase) (SKALP) (WAP four-disulfide core domain protein 14)
Protein symbol ELAF | UniProt ID | EVMP score 0.60 |
Frequency 20 | Transmembrane count | Protein classification Plasma proteinsPredicted secreted proteins |
Basic Information
Protein Names
Elafin (Elastase-specific inhibitor) (ESI) (Peptidase inhibitor 3) (PI-3) (Protease inhibitor WAP3) (Skin-derived antileukoproteinase) (SKALP) (WAP four-disulfide core domain protein 14)
Protein Class
Plasma proteinsPredicted secreted proteins
Protein Function
Predicted secreted proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
cementoinELAFINESISKALPWAP3WFDC14
Gene Description
Peptidase inhibitor 3
Chromosome
20
Position
45174902-45176544
Frequency
20
EVMP Score
0.60
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificBergmann glia
Function & Pathway
Protein Function
Predicted secreted proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Immune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted_peptidase_inhibitor | secreted_peptidase_inhibitor | OmniPath | No | No | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| ligand | ligand | iTALK | Yes | No | Yes | No | No |
| ligand | ligand | CellTalkDB | Yes | No | Yes | No | No |
| ligand | ligand | Guide2Pharma | Yes | No | Yes | No | No |
| ligand | ligand | OmniPath | Yes | No | Yes | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CSTADSPEVPLIVLKRT1KRT5LORICRINPI3SPRR3 | P01040P04264P07476P13647P15924P19957P23490Q92817Q9UBC9 | 1:1:1:1:1:1:1:1:1 | CompleatCFinder | Compleat:HC7996 | ||
| CSTADSPEVPLIVLKRT1LORICRINPI3 | P01040P04264P07476P15924P19957P23490Q92817 | 1:1:1:1:1:1:1 | CompleatCFinder | Compleat:HC6364 | ||
| PI3 | P19957 | 18 | PDB | PDB:6atu |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry | 1 | 38576002 |
Sequence, Structure & Domains
Sequences
Length
117
Mass
12,270
Sequence
MRASSFLIVVVFLIAGTLVLEAAVTGVPVKGQDTVKGRVPFNGQDPVKGQVSVKGQDKVKAQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCCEGSCGMACFVPQ
3D Structural Models
Helix
95..97
Beta Strand
65..69; 73..75; 81..84; 98..101; 103..106; 108..114
3D Structure
NMR spectroscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Repeat
29..54; SVP-1 clotting 1; 55..72; SVP-1 clotting 2
Domain (CC)
Consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize elafin covalently to specific sites on extracellular matrix proteins.
Domain (FT)
69..117; WAP
Region
29..72; 2 X tandem repeats of SVP-1 like motif
Clinical Relevance
Drugs