Protein detail
AT2B1
Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1)
Entry name AT2B1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 10 | Protein classification Disease related genesEnzymesFDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1)
Protein Class (7)
Disease related genesEnzymesFDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
106..126; Helical; 155..175; Helical; 367..386; Helical; 419..439; Helical; 856..876; Helical; 883..903; Helical; 928..948; Helical; 972..991; Helical; 1006..1027; Helical; 1040..1060; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
PMCA1
Gene Description
ATPase plasma membrane Ca2+ transporting 1
Chromosome
12
Position
89588049-89709366
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue SpecificesophagusCell SpecificBasal keratinocytesSingle-Nuclei Brain Specificamygdala excitatory
Function & Pathway7
Protein Function (5)
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component (12)
- GO:0001772 immunological synapse
- GO:0005654 nucleoplasm
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0030672 synaptic vesicle membrane
- GO:0042734 presynaptic membrane
- GO:0042995 cell projection
- GO:0043231 intracellular membrane-bounded organelle
- GO:0070062 extracellular exosome
Page 1 of 2
Molecular Function (8)
Biological Process (3)
KEGG (9)
- hsa04020 Calcium signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04961 Endocrine and other factor-regulated calcium reabsorption
- KEGG:hsa04970 Salivary secretion
- KEGG:hsa04972 Pancreatic secretion
- KEGG:hsa04978 Mineral absorption
Reactome (12)
- R-hsa-5576891 cardiac conduction
- R-hsa-109582 hemostasis
- R-hsa-983712 ion channel transport
- R-hsa-5578775 ion homeostasis
- R-hsa-936837 ion transport by p type atpases
- R-hsa-397014 muscle contraction
- R-hsa-418360 platelet calcium homeostasis
- R-hsa-418346 platelet homeostasis
- R-hsa-418359 reduction of cytosolic ca levels
- R-hsa-9709957 sensory perception
Page 1 of 2
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence23
Enzyme-Mediated Modification (3)
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ATP2B1 | PRKACA | P17612 | S | 1,178 | phosphorylation | HPRDKEA | KEA:2548572HPRD:2548572HPRD:19651622HPRD:20068231KEA:17081983HPRD:18669648 |
| ATP2B1 | INS | P01308 | S | 474 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:29104511 |
| ATP2B1 | PRKCA | P17252 | T | 1,116 | phosphorylation | KEA | KEA:1827443 |
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Page 2 of 2Previous
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KAPCA | P17612 | AT2B1 | P20020 | Yes | Yes | Yes | WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDCui2007PhosphoSite_KEAKEACA1HPRD_KEASIGNOR_ProtMapperHPRD-phos | KEA:2548572HPRD:2548572ProtMapper:19651622KEA:17081983ProtMapper:20068231HPRD-phos:20068231HPRD-phos:18669648HPRD-phos:2548572CA1:9824678ProtMapper:2548572ProtMapper:18669648SIGNOR:2548572HPRD-phos:19651622 |
Sequence, Structure & Domains11
Sequences
Length
1,220
Mass
134,685
Sequence
MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEMNKSATSSSPGSPLHSLETSL
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=B; Synonyms=CI, hPMCA1b; IsoId=P20020-3; Sequence=Displayed; Name=D; Synonyms=CIV, hPMCA1d; IsoId=P20020-1; Sequence=VSP_059773; Name=A; Synonyms=CII, hPMCA1a; IsoId=P20020-2; Sequence=VSP_059774, VSP_059775; Name=C; Synonyms=CIII, hPMCA1c; IsoId=P20020-4; Sequence=VSP_059772; Name=E; Synonyms=CV; IsoId=P20020-5; Sequence=VSP_059774, VSP_059776; Name=K; IsoId=P20020-6; Sequence=VSP_059771
Alternative Sequence
1021..1056; Missing (in isoform K); 1117; Q -> QMDVVNAFQSGSSIQGALRRQPSIASQHHD (in isoform C); 1117; Q -> QMDVVNAFQSGSSIQGALRRQPSIASQHHDVTNISTPTH (in isoform D); 1118..1119; IR -> MD (in isoform A and isoform E); 1125..1220; RSSLYEGLEKPESRSSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEMNKSATSSSPGSPLHSLETSL -> QSGSSIQGALRRQPSIASQHHDVTNISTPTHVVFSSSTASTTVGYSSGECIS (in isoform A); 1125..1220; RSSLYEGLEKPESRSSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEMNKSATSSSPGSPLHSLETSL -> QSGSSIQGALRRQPSIASQHHDVTNISTPTHVVFSSSTASTTVGFEW (in isoform E)
3D Structural Models
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Compositional Bias
312..325; Basic and acidic residues; 337..356; Basic and acidic residues; 1200..1220; Polar residues
Domain (CC)
Isoforms A, C, D and E contain an additional calmodulin-binding subdomain B which is different in the different splice variants and shows pH dependent calmodulin binding properties.
Region
297..356; Disordered; 1100..1117; Calmodulin-binding subdomain A; 1118..1220; Required for basolateral membrane targeting; 1160..1220; Disordered
Protein Families (2)
- Cation transport ATPase (P-type) (TC 3.A.3) family
- Type IIB subfamily
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
Clinical Relevance7
Disease Involvement (3)
Disease variantFDA approved drug targetsIntellectual disability
Drug Targets
FDA approved drug targets
Drugs (33)
Interaction Protein (5)
ENSG00000067842ENSG00000149136ENSG00000156642ENSG00000172270ENSG00000198668
Interaction Count
5
Interaction Dataset
biogrid_opencell
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |