Protein detail
CR2
Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21)
Entry name CR2 | UniProt ID | EVMP score 0.38 |
Frequency 8 | Transmembrane count 1 | Protein classification CD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21)
Protein Class
CD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
Transmembrane
972..999; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
C3DRCD21
Gene Description
Complement C3d receptor 2
Chromosome
1
Position
207453024-207489895
Frequency
8
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificAstrocytesSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
Cellular Component
Molecular Function
Biological Process
KEGG
Mediation Categories
Immune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
36 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CR2 | P20023 | CD19 | P15391 | Yes | Yes | No | WangNetPathSIGNORHPRDSPIKE_LCSPIKE | SIGNOR:31732528NetPath:14688345SPIKE:14688345NetPath:9597125HPRD:1702139SPIKE_LC:14688345 |
Protein Complex Composition
15 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CERF | CECR2SMARCA2 | P51531Q9BXF3 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C340 | |
| CERF chromatin remodelling complexSMARCA5 variant | CECR2SMARCA5 | O60264Q9BXF3 | 1:1 | ComplexPortal | intact:EBI-59037112 | 156402471475529228801535 |
| CERF complex (CECR2-containing remodeling factor complex) | CECR2SMARCA1 | P28370Q9BXF3 | 1:1 | CORUMCompleatComplexPortal | CORUM:917intact:EBI-11784735Compleat:HC2498 | 1564024714755292 |
| Cholesterol_byDHCR24 | DHCR24 | Q15392 | 1 | CellPhoneDBCellChatDB | CellPhoneDB:Cholesterol_byDHCR24 | |
| HT_DM_Cluster434 | CECR2SMARCA1SMARCA5 | O60264P28370Q9BXF3 | 1:1:1 | Compleat | Compleat:HC1163 | 22036573 |
| ALG10DHCR24RER1TMEM161A | O15258Q15392Q5BKT4Q9NX61 | 0:0:0:0 | hu.MAP | |||
| C3CR2 | P01024P20023 | 1:2 | PDB | PDB:1ghqPDB:3oedPDB:1w2s | ||
| NOL4LPYCR2RALYLSKA1SKA2SKA3 | Q86SE5Q8IX90Q8WVK7Q96BD8Q96C36Q96MY1 | 0:0:0:0:0:0 | hu.MAP2 | |||
| CRACR2AMCPH1 | Q8NEM0Q9BSW2 | 0:0 | hu.MAP | |||
| HAVCR2 | Q8TDQ0 | 2 | PDB | PDB:8tftPDB:5f71PDB:7m41PDB:6txz |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,033
Mass
112,916
Sequence
MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHLEAREVYSVDPYNPAS
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=A; IsoId=P20023-1; Sequence=Displayed; Name=B; IsoId=P20023-2; Sequence=VSP_001208, VSP_001209; Name=C; IsoId=P20023-3; Sequence=VSP_001210; Name=D; IsoId=P20023-4; Sequence=VSP_001210, VSP_001211
Alternative Sequence
499..524; Missing (in isoform B); 525..556; ITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTC -> NHLPTTPCYLQWGTHREFLRRFSIWNHGHLHM (in isoform B); 659; K -> KGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCE (in isoform C and isoform D); 716..723; Missing (in isoform D)
3D Structural Models
Beta Strand
32..34; 39..41; 46..51; 55..59; 62..66; 68..72; 74..77; 81..83; 99..103; 106..109; 113..118; 123..126; 128..132; 136..141; 145..147
3D Structure
Electron microscopy (1); X-ray crystallography (8)
Domain & Motif Annotations
Domain (FT)
21..84; Sushi 1; 89..148; Sushi 2; 152..212; Sushi 3; 213..273; Sushi 4; 274..344; Sushi 5; 349..408; Sushi 6; 409..468; Sushi 7; 469..524; Sushi 8; 525..595; Sushi 9; 600..659; Sushi 10; 660..716; Sushi 11; 717..781; Sushi 12; 786..845; Sushi 13; 849..909; Sushi 14; 910..970; Sushi 15
Protein Families
Receptors of complement activation (RCA) family
Sequence Similarities
Belongs to the receptors of complement activation (RCA) family.
Clinical Relevance
Disease Involvement
Systemic lupus erythematosus