Protein detail
CD22
B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)
Entry name CD22 | UniProt ID | EVMP confidence score 0.47 |
Supporting publications (n) 12 | Transmembrane count 1 | Protein classification CD markersFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)
Protein Class (5)
CD markersFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- CD markers
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Transmembrane
688..706; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
SIGLEC-2SIGLEC2
Gene Description
CD22 molecule
Chromosome
19
Position
35319261-35347361
Supporting publications (n)
12
EVMP confidence score
0.47
Fluorescence & Localization2
Cell SpecificAstrocytesSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway7
Protein Function (3)
- CD markers
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Cellular Component (9)
Molecular Function (7)
Biological Process (3)
KEGG (3)
Reactome (5)
- R-hsa-1280218 adaptive immune system
- R-hsa-983695 antigen activates b cell receptor bcr leading to generation of second messengers
- R-hsa-5690714 cd22 mediated bcr regulation
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-983705 signaling by the b cell receptor bcr
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence58
Enzyme-Mediated Modification (10)
10 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CD22 | ST6GAL1 | P15907 | N | 101 | glycosylation | SIGNOR | SIGNOR:8702538 |
| CD22 | SRC | P12931 | Y | 762 | phosphorylation | Li2012 | |
| CD22 | SRC | P12931 | Y | 807 | phosphorylation | Li2012 | |
| CD22 | SRC | P12931 | Y | 822 | phosphorylation | Li2012 | |
| CD22 | SRC | P12931 | Y | 842 | phosphorylation | Li2012 | |
| CD22 | PTPN6 | P29350 | Y | 762 | dephosphorylation | HPRD | HPRD:9890995 |
| CD22 | PTPN6 | P29350 | Y | 822 | dephosphorylation | HPRD | HPRD:9890995 |
| CD22 | LYN | P07948 | Y | 807 | phosphorylation | Reactome_ProtMapperProtMapper | |
| CD22 | LYN | P07948 | Y | 762 | phosphorylation | Reactome_ProtMapperProtMapper | |
| CD22 | LYN | P07948 | Y | 822 | phosphorylation | Reactome_ProtMapperProtMapper |
Ligand-Receptor Signaling (44)
44 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| ig_like | adhesion | Almen2009 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| LYN | P07948 | CD22 | P20273 | Yes | Yes | Yes | WangPhosphoPointSIGNORProtMapperHPRDHINTReactome_ProtMapperInnateDBSPIKE_LCSPIKE | HINT:8647200SPIKE_LC:17145710HPRD:8647200SPIKE_LC:9586639SIGNOR:32323266SPIKE:9586639InnateDB:10228003HINT:10748054 |
| SIAT1 | P15907 | CD22 | P20273 | Yes | No | Yes | CellTalkDBSIGNORconnectomeDB2020HPRDCellinkerWangLRdb | Cellinker:1717156HPRD:8702538SIGNOR:8702538connectomeDB2020:1717156LRdb:1717156CellTalkDB:1717156 |
| CD22 | P20273 | SH2B1 | Q9NRF2 | Yes | Yes | No | SIGNOR | SIGNOR:32323266 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains14
Sequences
Length
847
Mass
95,348
Sequence
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH
Alternative Products
Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=CD22-beta; IsoId=P20273-1; Sequence=Displayed; Name=CD22-alpha; IsoId=P20273-2; Sequence=VSP_002531; Name=3; IsoId=P20273-3; Sequence=VSP_045363; Name=4; IsoId=P20273-4; Sequence=VSP_047223, VSP_047224; Name=5; IsoId=P20273-5; Sequence=VSP_054619, VSP_054620
Alternative Sequence
1..3; MHL -> MSL (in isoform 5); 4..175; Missing (in isoform 5); 241..417; Missing (in isoform CD22-alpha); 330..417; Missing (in isoform 3); 737..751; VRRAPLSEGPHSLGC -> RCRVLRDAETSPGLR (in isoform 4); 752..847; Missing (in isoform 4)
3D Structural Models
Turn
66..69; 79..81
Helix
21..23; 82..84; 87..89; 111..113; 210..212; 301..303; 563..565; 651..653
Beta Strand
24..28; 30..35; 40..42; 45..48; 54..65; 70..78; 91..94; 98..101; 104..108; 115..122; 127..139; 144..146; 157..164; 172..178; 187..196; 198..206; 216..225; 228..235; 239..250; 251..253; 254..256; 261..272; 276..281; 284..286; 291..296; 305..312; 317..319; 323..327; 528..530; 543..545; 552..555; 567..572; 585..587; 590..602; 604..607; 612..622; 625..630; 636..638; 641..646; 655..662; 667..669; 673..678
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Motif
760..765; ITIM motif 1; 794..799; ITIM motif 2; 820..825; ITIM motif 3; 840..845; ITIM motif 4
Domain (CC)
Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain (FT)
20..138; Ig-like V-type; 143..235; Ig-like C2-type 1; 242..326; Ig-like C2-type 2; 331..416; Ig-like C2-type 3; 419..500; Ig-like C2-type 4; 505..582; Ig-like C2-type 5; 593..676; Ig-like C2-type 6
Protein Families (2)
- Immunoglobulin superfamily
- SIGLEC (sialic acid binding Ig-like lectin) family
Sequence Similarities
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Clinical Relevance9
Disease Involvement
FDA approved drug targets
Related Diseases (14)
Biomarker
Phase 1; Phase 1/2; Investigative; Phase 3; Approved
Drug Targets
FDA approved drug targets
Drugs (19)
EPRATUZUMABNULLIMMUNOTOXINOSPA PROTEINANTI-CD22 CAR T CELLS PREPARATIONINOTUZUMAB OZOGAMICINBECTUMOMABINOTUZUMABEPRATUZUMAB 90YMOXETUMOMAB PASUDOTOXMONO-DGA-RFB4DEGLYCOSYLATED RICIN A CHAIN-CONJUGATED ANTI-CD19/ANTI-CD22 IMMUNOTOXINSYTTRIUM Y 90 EPRATUZUMABANTI-CD22 CAR-EXPRESSING T LYMPHOCYTESAUTO3IMMURAIT-LL2BL22PINATUZUMAB VEDOTINYTTRIUM Y 90 EPRATUZUMAB TETRAXETAN
Interaction Protein (2)
ENSG00000111679ENSG00000254087
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications12
| PMID | Title | Abstract |
|---|---|---|
| 22106071 | Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT). | No abstract available |
| 25471207 | Intraluminal proteome and peptidome of human urinary extracellular vesicles. | No abstract available |
| 30071318 | Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No abstract available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |
| 38490958 | Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 38871730 | Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes. | No abstract available |
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