Protein detail
ACM3
Muscarinic acetylcholine receptor M3
Protein symbol ACM3 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 7 | Protein classification Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteins |
Basic Information
Protein Names
Muscarinic acetylcholine receptor M3
Protein Class
Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteins
Protein Function
- Disease related genes
- Human disease related genes:Other diseases:Others
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
68..91; Helical; Name=1; 105..130; Helical; Name=2; 143..164; Helical; Name=3; 185..206; Helical; Name=4; 230..252; Helical; Name=5; 492..514; Helical; Name=6; 527..546; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Description
Cholinergic receptor muscarinic 3
Chromosome
1
Position
239386565-239915452
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineCell SpecificColonocytesBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Other diseases:Others
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04020 Calcium signaling pathway
- KEGG:hsa04080 Neuroactive ligand-receptor interaction
- KEGG:hsa04082 Neuroactive ligand signaling
- KEGG:hsa04725 Cholinergic synapse
- KEGG:hsa04742 Taste transduction
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04911 Insulin secretion
- KEGG:hsa04970 Salivary secretion
- KEGG:hsa04971 Gastric acid secretion
- KEGG:hsa04972 Pancreatic secretion
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
Reactome
- R-hsa-399997 acetylcholine regulates insulin secretion
- R-hsa-375280 amine ligand binding receptors
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-416476 g alpha q signalling events
- R-hsa-163685 integration of energy metabolism
- R-hsa-390648 muscarinic acetylcholine receptors
- R-hsa-422356 regulation of insulin secretion
- R-hsa-372790 signaling by gpcr
Canonical Pathways
- M88 Pid cd8 tcr pathway
- M54 Pid il12 2pathway
- M272 Pid cd8 tcr downstream pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
62 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
| gpcr | receptor | Almen2009 | No | Yes | No | Yes | No |
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Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ACM3 | P20309 | GNAI1 | P63096 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| ACM3 | P20309 | GNAQ | P50148 | Yes | Yes | No | KEGG-MEDICUSHPRDWangSIGNOR | HPRD:7629074SIGNOR:31160049 |
| ACM3 | P20309 | GNA14 | O95837 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| ACM3 | P20309 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| ACM3 | P20309 | GNA15 | P30679 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
590
Mass
66,128
Sequence
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
3D Structural Models
Turn
173..175; 545..547
Helix
65..95; 97..99; 102..104; 105..119; 121..130; 138..171; 176..179; 182..210; 231..239; 241..264; 489..502; 505..516; 523..533; 535..544; 549..560
Beta Strand
131..133; 211..213; 224..228; 280..283; 518..521
3D Structure
Electron microscopy (4); NMR spectroscopy (1)
Domain & Motif Annotations
Compositional Bias
334..345; Low complexity
Motif
275..281; Basolateral sorting signal
Region
323..357; Disordered
Protein Families
- G-protein coupled receptor 1 family
- Muscarinic acetylcholine receptor subfamily
- CHRM3 sub-subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Discontinued in Phase 3; Terminated; Approved
Drug Targets
FDA approved drug targets
Drugs
BENZQUINAMIDEDICYCLOMINE HYDROCHLORIDENULLMETHIXENEASM-024TALSACLIDINECHEMBL:CHEMBL1084941ATROPINEOCTOTROPINE METHYLBROMIDEZAMIFENACINOXYPHENCYCLIMINE HYDROCHLORIDEPIPERTRAMINE AMIDEACECLIDINEACLIDINIUMPROMETHAZINE HYDROCHLORIDEPROMAZINEDAROTROPIUM BROMIDEAFACIFENACINTARAFENACINCEVIMELINETHIETHYLPERAZINEMETHOTRIMEPRAZINEGLYCOPYRRONIUMOLANZAPINEDOXEPIN HYDROCHLORIDEOXYPHENCYCLIMINEOXYBUTYNINTOLTERODINETROPICAMIDESOLIFENACIN SUCCINATETIOTROPIUM BROMIDELAS190792HEXOCYCLIUM METHYLSULFATEFESOTERODINEDIPHENIDOLTRIDIHEXETHYL CHLORIDEIPRATROPIUM CATIONMETHYLHOMATROPINETIOTROPIUMACETYLCHOLINE CHLORIDEMETHSCOPOLAMINE BROMIDESUCCINYLCHOLINECLIDINIUMCCG-50014AZD8683CEVIMELINE HYDROCHLORIDEDEXAMETHASONEMETHSCOPOLAMINECARBAMOYLCHOLINEPILOCARPINE HYDROCHLORIDEACLIDINIUM BROMIDETRIDIHEXETHYLDIPHEMANIL METHYLSULFATESOLIFENACINISOPROPAMIDE IODIDEDARIFENACINAZD-9164SOFPIRONIUM BROMIDEATROPINE SULFATEREVEFENACINBETHANECHOL CHLORIDETROSPIUMTERODILINE HYDROCHLORIDENAVAFENTEROLUMECLIDINIUM BROMIDEPROPIOMAZINEMEPENZOLATE BROMIDEOXYPHENONIUM BROMIDECYCLOPENTOLATE HYDROCHLORIDEPROPANTHELINE BROMIDEBATEFENTEROLIMIDAFENACINMETHACHOLINE CHLORIDEPIPERTRAMINE