Protein detail
MDR3
Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (P-glycoprotein 3)
Protein symbol MDR3 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 12 | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (P-glycoprotein 3)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Liver diseases
- Potential drug targets
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
Transmembrane
51..73; Helical; 119..139; Helical; 189..210; Helical; 218..238; Helical; 297..318; Helical; 333..354; Helical; 712..732; Helical; 756..776; Helical; 832..852; Helical; 854..873; Helical; 934..956; Helical; 973..994; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
GBD1MDR2MDR3PFIC-3PGY3
Gene Description
ATP binding cassette subfamily B member 4
Chromosome
7
Position
87401696-87480435
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Liver diseases
- Potential drug targets
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M290 Pid il12 stat4 pathway
- M54 Pid il12 2pathway
- M34 Pid tcr pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| abc | transporter | DGIdb | No | Yes | No | No | No |
| transporter | transporter | DGIdb | No | Yes | No | No | No |
| active | transporter | Surfaceome | No | Yes | No | No | No |
| abcb | transporter | Surfaceome | No | Yes | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
1,286
Mass
141,523
Sequence
MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P21439-1; Sequence=Displayed; Name=2; IsoId=P21439-2; Sequence=VSP_023263; Name=3; IsoId=P21439-3; Sequence=VSP_046258, VSP_023263
Alternative Sequence
929..975; Missing (in isoform 3); 1094..1100; Missing (in isoform 2 and isoform 3)
3D Structural Models
Turn
45..48; 619..621; 1045..1048; 1107..1109; 1240..1245
Helix
51..68; 70..73; 75..78; 108..159; 162..167; 173..187; 190..212; 214..221; 224..261; 263..268; 272..324; 330..349; 351..372; 435..442; 460..462; 465..471; 486..494; 499..508; 512..517; 521..523; 528..530; 535..547; 565..578; 614..618; 623..628; 697..700; 708..722; 724..738; 747..795; 800..804; 810..828; 831..852; 854..860; 861..863; 864..901; 903..909; 912..965; 970..1012; 1075..1083; 1112..1117; 1133..1138; 1148..1157; 1161..1166; 1177..1179; 1184..1196; 1214..1227
Beta Strand
394..398; 404..406; 424..428; 452..455; 472..475; 483..485; 518..520; 552..558; 583..587; 598..604; 607..612; 739..742; 744..746; 796..798; 1034..1038; 1051..1053; 1056..1059; 1064..1068; 1119..1122; 1130..1132; 1167..1171; 1201..1207; 1209..1212; 1231..1236; 1247..1253
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Domain (FT)
57..359; ABC transmembrane type-1 1; 394..630; ABC transporter 1; 711..999; ABC transmembrane type-1 2; 1034..1279; ABC transporter 2
Region
625..647; Interaction with HAX1
Protein Families
- ABC transporter superfamily
- ABCB family
- Multidrug resistance exporter (TC 3.A.1.201) subfamily
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Clinical Relevance
Disease Involvement
Disease variantIntrahepatic cholestasis
Related Diseases
Biomarker
Discontinued in Phase 3; Phase 2
Drug Targets
Clinical trial target