Protein detail
MDR3
Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (P-glycoprotein 3)
Entry name MDR3 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 4 | Transmembrane count 12 | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (P-glycoprotein 3)
Protein Class (9)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (7)
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Liver diseases
- Potential drug targets
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
Transmembrane
51..73; Helical; 119..139; Helical; 189..210; Helical; 218..238; Helical; 297..318; Helical; 333..354; Helical; 712..732; Helical; 756..776; Helical; 832..852; Helical; 854..873; Helical; 934..956; Helical; 973..994; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
GBD1MDR2MDR3PFIC-3PGY3
Gene Description
ATP binding cassette subfamily B member 4
Chromosome
7
Position
87401696-87480435
Supporting publications (n)
4
EVMP confidence score
0.53
Function & Pathway
Protein Function (7)
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Liver diseases
- Potential drug targets
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
Cellular Component (11)
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0016020 membrane
- GO:0016324 apical plasma membrane
- GO:0030136 clathrin-coated vesicle
- GO:0045121 membrane raft
- GO:0046581 intercellular canaliculus
Page 1 of 2
Molecular Function (7)
Biological Process (3)
Reactome (6)
Canonical Pathways (3)
- M290 Pid il12 stat4 pathway
- M54 Pid il12 2pathway
- M34 Pid tcr pathway
Mediation Categories (4)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence27
Ligand-Receptor Signaling (26)
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| transporter | transporter | Surfaceome | Yes | ||||
| abc | transporter | DGIdb | Yes | ||||
| transporter | transporter | DGIdb | Yes | ||||
| active | transporter | Surfaceome | Yes | ||||
| abcb | transporter | Surfaceome | Yes |
Page 1 of 3Next
Sequence, Structure & Domains
Sequences
Length
1,286
Mass
141,523
Sequence
MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P21439-1; Sequence=Displayed; Name=2; IsoId=P21439-2; Sequence=VSP_023263; Name=3; IsoId=P21439-3; Sequence=VSP_046258, VSP_023263
Alternative Sequence
929..975; Missing (in isoform 3); 1094..1100; Missing (in isoform 2 and isoform 3)
3D Structural Models
Turn
45..48; 619..621; 1045..1048; 1107..1109; 1240..1245
Helix
51..68; 70..73; 75..78; 108..159; 162..167; 173..187; 190..212; 214..221; 224..261; 263..268; 272..324; 330..349; 351..372; 435..442; 460..462; 465..471; 486..494; 499..508; 512..517; 521..523; 528..530; 535..547; 565..578; 614..618; 623..628; 697..700; 708..722; 724..738; 747..795; 800..804; 810..828; 831..852; 854..860; 861..863; 864..901; 903..909; 912..965; 970..1012; 1075..1083; 1112..1117; 1133..1138; 1148..1157; 1161..1166; 1177..1179; 1184..1196; 1214..1227
Beta Strand
394..398; 404..406; 424..428; 452..455; 472..475; 483..485; 518..520; 552..558; 583..587; 598..604; 607..612; 739..742; 744..746; 796..798; 1034..1038; 1051..1053; 1056..1059; 1064..1068; 1119..1122; 1130..1132; 1167..1171; 1201..1207; 1209..1212; 1231..1236; 1247..1253
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Domain (FT)
57..359; ABC transmembrane type-1 1; 394..630; ABC transporter 1; 711..999; ABC transmembrane type-1 2; 1034..1279; ABC transporter 2
Region
625..647; Interaction with HAX1
Protein Families (3)
- ABC transporter superfamily
- ABCB family
- Multidrug resistance exporter (TC 3.A.1.201) subfamily
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Clinical Relevance
Disease Involvement (2)
Disease variantIntrahepatic cholestasis
Related Diseases (4)
Biomarker
Discontinued in Phase 3; Phase 2
Drug Targets
Clinical trial target
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 26538482 | Insights into immune responses in oral cancer through proteomic analysis of saliva and salivary extracellular vesicles. | No related sentences available |
| 37862381 | Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. | Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 38937789 | The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages. | No related sentences available |