Protein detail

MDR3

Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (P-glycoprotein 3)

Entry name MDR3	UniProt ID P21439	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 12	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (P-glycoprotein 3)

Protein Class (9)

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (7)

Predicted intracellular proteins
Human disease related genes:Digestive system diseases:Liver diseases
Potential drug targets
Enzymes
ENZYME proteins
Transporters:Primary Active Transporters
Disease related genes

Transmembrane

51..73; Helical; 119..139; Helical; 189..210; Helical; 218..238; Helical; 297..318; Helical; 333..354; Helical; 712..732; Helical; 756..776; Helical; 832..852; Helical; 854..873; Helical; 934..956; Helical; 973..994; Helical

Transmembrane Count

Ensembl

ENSG00000005471

Entrez Gene Symbol

ABCB4

Gene Synonym (5)

GBD1MDR2MDR3PFIC-3PGY3

Gene Description

ATP binding cassette subfamily B member 4

Chromosome

Position

87401696-87480435

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway8

Protein Function (7)

Predicted intracellular proteins
Human disease related genes:Digestive system diseases:Liver diseases
Potential drug targets
Enzymes
ENZYME proteins
Transporters:Primary Active Transporters
Disease related genes

Cellular Component (11)

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Molecular Function (7)

Biological Process (3)

KEGG (2)

Reactome (6)

Canonical Pathways (3)

M290 Pid il12 stat4 pathway
M54 Pid il12 2pathway
M34 Pid tcr pathway

Mediation Categories (4)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence27

Ligand-Receptor Signaling (26)

26 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
abc	transporter	DGIdb	No	Yes	No	No	No
transporter	transporter	DGIdb	No	Yes	No	No	No
active	transporter	Surfaceome	No	Yes	No	No	No
abcb	transporter	Surfaceome	No	Yes	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	2	38113368 41307968

Sequence, Structure & Domains13

Sequences

Length

1,286

Mass

141,523

Sequence

MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P21439-1; Sequence=Displayed; Name=2; IsoId=P21439-2; Sequence=VSP_023263; Name=3; IsoId=P21439-3; Sequence=VSP_046258, VSP_023263

Alternative Sequence

929..975; Missing (in isoform 3); 1094..1100; Missing (in isoform 2 and isoform 3)

3D Structural Models

Turn

45..48; 619..621; 1045..1048; 1107..1109; 1240..1245

Helix

51..68; 70..73; 75..78; 108..159; 162..167; 173..187; 190..212; 214..221; 224..261; 263..268; 272..324; 330..349; 351..372; 435..442; 460..462; 465..471; 486..494; 499..508; 512..517; 521..523; 528..530; 535..547; 565..578; 614..618; 623..628; 697..700; 708..722; 724..738; 747..795; 800..804; 810..828; 831..852; 854..860; 861..863; 864..901; 903..909; 912..965; 970..1012; 1075..1083; 1112..1117; 1133..1138; 1148..1157; 1161..1166; 1177..1179; 1184..1196; 1214..1227

Beta Strand

394..398; 404..406; 424..428; 452..455; 472..475; 483..485; 518..520; 552..558; 583..587; 598..604; 607..612; 739..742; 744..746; 796..798; 1034..1038; 1051..1053; 1056..1059; 1064..1068; 1119..1122; 1130..1132; 1167..1171; 1201..1207; 1209..1212; 1231..1236; 1247..1253

3D Structure

Electron microscopy (4)

Domain & Motif Annotations

Domain (FT)

57..359; ABC transmembrane type-1 1; 394..630; ABC transporter 1; 711..999; ABC transmembrane type-1 2; 1034..1279; ABC transporter 2

Region

625..647; Interaction with HAX1

Protein Families (3)

ABC transporter superfamily
ABCB family
Multidrug resistance exporter (TC 3.A.1.201) subfamily

Sequence Similarities

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Clinical Relevance6

Disease Involvement (2)

Disease variantIntrahepatic cholestasis

Related Diseases (3)

Acute myeloid leukaemia Breast cancer Solid tumour/cancer

Biomarker

Discontinued in Phase 3; Phase 2

Drug Targets

Clinical trial target

Drugs (5)

IMATINIB VINCRISTINE VINBLASTINE CYCLOSPORINE MITOMYCIN

Antibody (2)

HPA049395 HPA053288

Supporting Publications4

PMID	Title	Abstract
26538482	Insights into immune responses in oral cancer through proteomic analysis of saliva and salivary extracellular vesicles.	No abstract available
37862381	Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
38937789	The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages.	No abstract available