Protein detail
S1PR1
Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363)
Protein symbol S1PR1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 7 | Protein classification Cancer-related genesCD markersFDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363)
Protein Class
Cancer-related genesCD markersFDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters
Protein Function
- G-protein coupled receptors:Lysolipids receptors
- Transporters
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- G-protein coupled receptors:GPCRs excl olfactory receptors
- FDA approved drug targets:Small molecule drugs
Transmembrane
47..68; Helical; Name=1; 83..104; Helical; Name=2; 117..138; Helical; Name=3; 161..182; Helical; Name=4; 197..224; Helical; Name=5; 258..278; Helical; Name=6; 290..310; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
CD363D1S3362edg-1EDG1
Gene Description
Sphingosine-1-phosphate receptor 1
Chromosome
1
Position
101236865-101243713
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorSecretome LocationIntracellular and membraneSecretome FunctionTransport
Function & Pathway
Protein Function
- G-protein coupled receptors:Lysolipids receptors
- Transporters
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- G-protein coupled receptors:GPCRs excl olfactory receptors
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-500792 gpcr ligand binding
- R-hsa-5663205 infectious disease
- R-hsa-6785807 interleukin 4 and interleukin 13 signaling
- R-hsa-419408 lysosphingolipid and lpa receptors
- R-hsa-9679191 potential therapeutics for sars
- R-hsa-9679506 sars cov infections
- R-hsa-372790 signaling by gpcr
- R-hsa-449147 signaling by interleukins
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| S1PR1 | AKT1 | P31749 | T | 236 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDdbPTMKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:17570479KEA:11583630dbPTM:11583630ProtMapper:11583630HPRD:11583630SIGNOR:11583630 |
| S1PR1 | PDK1 | Q15118 | T | 236 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| S1PR1 | PRKCA | P17252 | T | 236 | phosphorylation | KEA | KEA:17570479 |
| S1PR1 | RPS6KA3 | P51812 | T | 236 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
52 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | Surfaceome | No | Yes | No | Yes | No |
| class_a_rhodopsin | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_lipid | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_lipid_lysophospholipid_s1p | receptor | GPCRdb | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| AKT1 | P31749 | S1PR1 | P21453 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperdbPTMPhosphoSite_KEAHPRDWangPhosphoSite_ProtMapperNetworKIN_KEAHPRD-phosphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteSPIKE_LCSPIKE | KEA:17570479KEA:11583630HPRD-phos:11583630dbPTM:11583630SPIKE:11583630PhosphoSite:25588843ProtMapper:11583630SPIKE_LC:11583630PhosphoSite:11583630HPRD:11583630SIGNOR:11583630 |
| S1PR1 | P21453 | GNAI3 | P08754 | Yes | Yes | No | HPRDWangLit-BM-17SIGNOR | Lit-BM-17:8626678HPRD:8626678SIGNOR:31160049 |
| S1PR1 | P21453 | GNAZ | P19086 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| ZDHC5 | Q9C0B5 | S1PR1 | P21453 | Yes | Yes | No | SIGNOR | SIGNOR:29185452 |
| S1PR1 | P21453 | GNAO | P09471 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| S1PR1 | P21453 | GNAI1 | P63096 | Yes | Yes | No | WangSIGNORHPRDHINTSPIKE_LCLit-BM-17 | SIGNOR:31160049Lit-BM-17:8626678HPRD:8626678HINT:34526663HINT:35412894HINT:37039481HINT:34937912SPIKE_LC:16189514HINT:8626678 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
382
Mass
42,811
Sequence
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
3D Structural Models
Turn
74..77; 109..111; 177..180; 234..236; 284..286
Helix
23..32; 36..39; 48..72; 79..103; 106..108; 114..148; 158..176; 188..190; 200..233; 249..281; 289..291; 294..313; 318..322
Beta Strand
151..153; 183..186; 193..195; 245..248; 314..317
3D Structure
Electron microscopy (15); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
351..366; Basic and acidic residues; 371..382; Polar residues
Region
350..382; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
Cancer-related genesFDA approved drug targets
Related Diseases
Biomarker
Phase 1; Phase 2; Phase 3; Approved; Investigative; Terminated
Drug Targets
FDA approved drug targets
Drugs
PONESIMODNULLFINGOLIMODFINGOLIMOD LAURYL SULFATEETRASIMODKRP203CENERIMODAMISELIMOD HYDROCHLORIDEOZANIMOD HYDROCHLORIDEASP-4058BMS-986104OZANIMODSIPONIMODFINGOLIMOD HYDROCHLORIDE9,10-PHENANTHRENEQUINONESAR 247799.00CHEMBL:CHEMBL1362503AMISELIMODGSK-2018682CHEMBL:CHEMBL171699SIPONIMOD FUMARATE(S)-FTY720PISOVELLERALCHEMBL:CHEMBL586135CHEMBL:CHEMBL579318SONEPCIZUMABPINAFIDEMOCRAVIMOD HYDROCHLORIDE