Protein detail

ZNF10

Zinc finger protein 10 (Zinc finger protein KOX1)

Entry name ZNF10	UniProt ID P21506	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteinsTranscription factors

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Zinc finger protein 10 (Zinc finger protein KOX1)

Protein Class (2)

Predicted intracellular proteinsTranscription factors

Protein Function (2)

Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Ensembl

ENSG00000256223

Entrez Gene Symbol

ZNF10

Gene Synonym

KOX1

Gene Description

Zinc finger protein 10

Chromosome

Position

133130575-133159465

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Cell SpecificEpididymal basal cellsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway6

Protein Function (2)

Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

Reactome

R-hsa-73857 rna polymerase ii transcription

Mediation Categories

Other mediation

Relations & Evidence13

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (8)

8 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CEP85L DUSP11 KLHL40 KLHL41 ZNF106 ZNF81	O60662 O75319 P51508 Q2TBA0 Q5SZL2 Q9H2Y7	0:0:0:0:0:0	hu.MAP2
CEP85L KLHL40 KLHL41 ZNF106 ZNF81	O60662 P51508 Q2TBA0 Q5SZL2 Q9H2Y7	0:0:0:0:0	hu.MAP2
BRCA1 CREB1 PIAS1 RAD51 SAE1 SUMO2 SUMO3 TP53 UBA2 UBE2I ZNF106	O75925 P04637 P16220 P38398 P55854 P61956 P63279 Q06609 Q9H2Y7 Q9UBE0 Q9UBT2	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4911
HRC ZNF101	P23327 Q8IZC7	0:0	hu.MAP2
BMS1 BOP1 DDX10 DDX56 KNOP1 UTP18 UTP3 ZNF106	Q13206 Q14137 Q14692 Q1ED39 Q9H2Y7 Q9NQZ2 Q9NY93 Q9Y5J1	0:0:0:0:0:0:0:0	hu.MAP2
DDX10 KNOP1 ZNF106	Q13206 Q1ED39 Q9H2Y7	0:0:0	hu.MAP2
KNOP1 ZNF106	Q1ED39 Q9H2Y7	0:0	hu.MAP2
CCDC71L HES6 NEUROG2 NEUROG3 PKDCC ZNF100	Q504Y2 Q8IYN0 Q8N9Z2 Q96HZ4 Q9H2A3 Q9Y4Z2	0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains7

Sequences

Length

573

Mass

66,455

Sequence

MDAKSLTAWSRTLVTFKDVFVDFTREEWKLLDTAQQIVYRNVMLENYKNLVSLGYQLTKPDVILRLEKGEEPWLVEREIHQETHPDSETAFEIKSSVSSRSIFKDKQSCDIKMEGMARNDLWYLSLEEVWKCRDQLDKYQENPERHLRQVAFTQKKVLTQERVSESGKYGGNCLLPAQLVLREYFHKRDSHTKSLKHDLVLNGHQDSCASNSNECGQTFCQNIHLIQFARTHTGDKSYKCPDNDNSLTHGSSLGISKGIHREKPYECKECGKFFSWRSNLTRHQLIHTGEKPYECKECGKSFSRSSHLIGHQKTHTGEEPYECKECGKSFSWFSHLVTHQRTHTGDKLYTCNQCGKSFVHSSRLIRHQRTHTGEKPYECPECGKSFRQSTHLILHQRTHVRVRPYECNECGKSYSQRSHLVVHHRIHTGLKPFECKDCGKCFSRSSHLYSHQRTHTGEKPYECHDCGKSFSQSSALIVHQRIHTGEKPYECCQCGKAFIRKNDLIKHQRIHVGEETYKCNQCGIIFSQNSPFIVHQIAHTGEQFLTCNQCGTALVNTSNLIGYQTNHIRENAY

Domain & Motif Annotations

Zinc Finger

206..232; C2H2-type 1; atypical; 265..287; C2H2-type 2; 293..315; C2H2-type 3; 321..343; C2H2-type 4; 349..371; C2H2-type 5; 377..399; C2H2-type 6; 405..427; C2H2-type 7; 433..455; C2H2-type 8; 461..483; C2H2-type 9; 489..511; C2H2-type 10; 517..539; C2H2-type 11; atypical

Domain (FT)

14..85; KRAB

Protein Families

Krueppel C2H2-type zinc-finger protein family

Sequence Similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Clinical Relevance4

Antibody

HPA003204

Interaction Protein

ENSG00000130726

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Abstract
34265469	Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer.	Furthermore, utilizing quantitative proteomics approach to reveal the proteomes of CD151-deleted exosomes and cells, we found that exosomal CD151 facilitated secretion of ribosomal proteins via exosomes while inhibiting exosome secretion of complement proteins. Moreover, we proved that CD151-deleted exosomes significantly decreased the migration and invasion of TNBC cells. Most importantly, we found that the tetraspanin CD151 expression levels in TNBC-derived serum exosomes were significantly higher than those exosomes from healthy subjects, and we validated our findings with samples from 16 additional donors. This is the first comparative study of the proteomes of TNBC patient-derived and CD151-deleted exosomes.
39996590	Surface Double Dendritic Magnetic Microfibrils for Rapid Isolation and Proteomic Profiling of Extracellular Vesicles from Microliters of Biofluids.	No abstract available