Protein detail
CNR1
Cannabinoid receptor 1 (CB-R) (CB1) (CANN6)
Protein symbol CNR1 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 7 | Protein classification Disease related genesFDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Cannabinoid receptor 1 (CB-R) (CB1) (CANN6)
Protein Class
Disease related genesFDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
117..142; Helical; Name=1; 155..175; Helical; Name=2; 188..212; Helical; Name=3; 233..255; Helical; Name=4; 274..299; Helical; Name=5; 345..365; Helical; Name=6; 378..399; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
CANN6CB-RCB1CB1ACB1K5CNR
Gene Description
Cannabinoid receptor 1
Chromosome
6
Position
88139864-88166347
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Transporters
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CNR1 | PTK2 | Q05397 | Y | 397 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:28826534 |
Ligand-Receptor Signaling
53 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | UniProt_keyword | No | Yes | No | Yes | No |
| seven_transmembrane_7tm | receptor | HPMR | No | Yes | No | Yes | No |
| 7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| lysosphingolipid_lysophosphatidic_acid_edg_7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| rhodopsin | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | Surfaceome | No | Yes | No | Yes | No |
| class_a_rhodopsin | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_lipid | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_lipid_cannabinoid | receptor | GPCRdb | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
Regulatory Interaction Network
8 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CNR1 | P21554 | GNAI3 | P08754 | Yes | Yes | No | SIGNORHPRDCui2007CA1Wang | CA1:15082510HPRD:11168387SIGNOR:31160049 |
| CNR1 | P21554 | GNAO | P09471 | Yes | Yes | No | WangCui2007SIGNORCA1 | CA1:15082510SIGNOR:31160049 |
| CNR1 | P21554 | OX1R | O43613 | Yes | Yes | No | HPRDSIGNOR | HPRD:12690115SIGNOR:29751001 |
| CNR1 | P21554 | GNA14 | O95837 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| CNR1 | P21554 | GNA12 | Q03113 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| CNR1 | P21554 | GNAZ | P19086 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| CNR1 | P21554 | GNA13 | Q14344 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| CNR1 | P21554 | GNAI1 | P63096 | Yes | Yes | No | HPRDHINTSIGNOR | HINT:30639101HINT:28734930HINT:37160876SIGNOR:31160049HINT:32004463HPRD:11168387 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
472
Mass
52,858
Sequence
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=P21554-1; Sequence=Displayed; Name=2; Synonyms=CB1a, Short; IsoId=P21554-2; Sequence=VSP_001868; Name=3; Synonyms=CB1b; IsoId=P21554-3; Sequence=VSP_016529
Alternative Sequence
1..89; MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSF -> MALQIPPSAPSPLTSCTWAQMTFSTKTS (in isoform 2); 22..54; Missing (in isoform 3)
3D Structural Models
Turn
221..223
Helix
105..107; 113..143; 145..148; 151..153; 154..178; 186..219; 224..227; 230..249; 250..253; 257..260; 273..300; 302..305; 306..309; 334..367; 375..400; 402..409; 411..415
Beta Strand
100..102; 266..268
3D Structure
Electron microscopy (18); NMR spectroscopy (7); X-ray crystallography (7)
Domain & Motif Annotations
Region
2..23; Required for mitochondrial localization
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
FDA approved drug targetsNeurodegenerationObesity
Drug Targets
FDA approved drug targets
Drugs
SURINABANTTARANABANTNULLRIMONABANTANISINDIONENP118809TEBIPENEMNONABINEV24343DRONABINOLOTENABANTDRINABANTCP55940AMAUROMINEORLISTATIBIPINABANTCANNABIDIOLHEMOPRESSINAVE-1625NABILONEAZD22072-ARACHIDONYL GLYCERYL ETHERSAD448N-[6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-YL]-4,4,4-TRIFLUORO-3-HYDROXYBUTANAMIDE (DIASTEREOMERIC MIX)TM38837CHEMBL:CHEMBL498746NIMACIMABJD50372-ARACHIDONOYLGLYCEROLCONATUMUMABWIN55212-2