Protein detail

CNR1

Cannabinoid receptor 1 (CB-R) (CB1) (CANN6)

Protein symbol CNR1	UniProt ID P21554	EVMP score 0.50
Frequency 2	Transmembrane count 7	Protein classification Disease related genesFDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Cannabinoid receptor 1 (CB-R) (CB1) (CANN6)

Protein Class

Disease related genesFDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

117..142; Helical; Name=1; 155..175; Helical; Name=2; 188..212; Helical; Name=3; 233..255; Helical; Name=4; 274..299; Helical; Name=5; 345..365; Helical; Name=6; 378..399; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000118432

Entrez Gene Symbol

CNR1

Gene Synonym

CANN6CB-RCB1CB1ACB1K5CNR

Gene Description

Cannabinoid receptor 1

Chromosome

Position

88139864-88166347

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Transporters
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CNR1	PTK2	Q05397	Y	397	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:28826534

Ligand-Receptor Signaling

53 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No

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Regulatory Interaction Network

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CNR1	P21554	GNAI3	P08754	Yes	Yes	No	SIGNORHPRDCui2007CA1Wang	CA1:15082510 HPRD:11168387 SIGNOR:31160049
CNR1	P21554	GNAO	P09471	Yes	Yes	No	WangCui2007SIGNORCA1	CA1:15082510 SIGNOR:31160049
CNR1	P21554	OX1R	O43613	Yes	Yes	No	HPRDSIGNOR	HPRD:12690115 SIGNOR:29751001
CNR1	P21554	GNA14	O95837	Yes	Yes	No	SIGNOR	SIGNOR:31160049
CNR1	P21554	GNA12	Q03113	Yes	Yes	No	SIGNOR	SIGNOR:31160049
CNR1	P21554	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
CNR1	P21554	GNA13	Q14344	Yes	Yes	No	SIGNOR	SIGNOR:31160049
CNR1	P21554	GNAI1	P63096	Yes	Yes	No	HPRDHINTSIGNOR	HINT:30639101 HINT:28734930 HINT:37160876 SIGNOR:31160049 HINT:32004463 HPRD:11168387

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ARRB1 AVPR2 CNR1	P21554 P30518 P49407	1:1:1	PDB	PDB:8wrz

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blotting	3	24505114 40098346 31588238

Sequence, Structure & Domains

Sequences

Length

472

Mass

52,858

Sequence

MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=P21554-1; Sequence=Displayed; Name=2; Synonyms=CB1a, Short; IsoId=P21554-2; Sequence=VSP_001868; Name=3; Synonyms=CB1b; IsoId=P21554-3; Sequence=VSP_016529

Alternative Sequence

1..89; MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSF -> MALQIPPSAPSPLTSCTWAQMTFSTKTS (in isoform 2); 22..54; Missing (in isoform 3)

3D Structural Models

Turn

221..223

Helix

105..107; 113..143; 145..148; 151..153; 154..178; 186..219; 224..227; 230..249; 250..253; 257..260; 273..300; 302..305; 306..309; 334..367; 375..400; 402..409; 411..415

Beta Strand

100..102; 266..268

3D Structure

Electron microscopy (18); NMR spectroscopy (7); X-ray crystallography (7)

Domain & Motif Annotations

Region

2..23; Required for mitochondrial localization

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Disease Involvement

FDA approved drug targetsNeurodegenerationObesity

Drug Targets

FDA approved drug targets

Antibody

HPA042256 HPA069945