Protein detail

EPHA1

Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)

Entry name EPHA1	UniProt ID P21709	EVMP confidence score 0.25
Supporting publications (n) 3	Transmembrane count 1	Protein classification Cancer-related genesEnzymesPlasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)

Protein Class (4)

Cancer-related genesEnzymesPlasma proteinsPredicted membrane proteins

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Kinases:Tyr protein kinases

Transmembrane

548..568; Helical

Transmembrane Count

Ensembl

ENSG00000146904

Entrez Gene Symbol

EPHA1

Gene Synonym (3)

EPHEPHTEPHT1

Gene Description

EPH receptor A1

Chromosome

Position

143390289-143408856

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Tissue SpecificliverCell SpecificEndometrial luminal cells

Function & Pathway7

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Kinases:Tyr protein kinases

Cellular Component (2)

Molecular Function (6)

Biological Process (3)

KEGG

hsa04360 Axon guidance

Reactome (6)

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence66

Ligand-Receptor Signaling (62)

62 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	Baccin2019	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EFNA1	P20827	EPHA1	P21709	Yes	Yes	No	iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:9330863 Cellinker:15114347 SIGNOR:9576626 Baccin2019:9330863 connectomeDB2020:11519828 connectomeDB2020:8755474 Cellinker:11519828 SignaLink3:11519828 SignaLink3:8755474 Cellinker:8755474 SignaLink3:18988627 LRdb:11114742 CellChatDB:15114347 SignaLink3:23331499 HPRD:11519828 connectomeDB2020:9330863 Baccin2019:8755474 HPMR:9330863 ICELLNET:24003208 HPRD:8755474 SIGNOR:9330863 Baccin2019:11519828 ICELLNET:15114347 SignaLink3:9267020

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	EPHA1	P21709	2	PDB	PDB:3hilPDB:2k1kPDB:2k1l
	EPHA10 EPHA7	Q15375 Q5JZY3	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains12

Sequences

Length

976

Mass

108,127

Sequence

MERRWPLGLGLVLLLCAPLPPGARAKEVTLMDTSKAQGELGWLLDPPKDGWSEQQQILNGTPLYMYQDCPMQGRRDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKETFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLVSGSVKLNVERCSLGRLTRRGLYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTLPGPAGLVEVAGTCLPHARASPRPSGAPRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEACVACPSGSYRMDMDTPHCLTCPQQSTAESEGATICTCESGHYRAPGEGPQVACTGPPSAPRNLSFSASGTQLSLRWEPPADTGGRQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHFSPGARGLTTPAVHVNGLEPYANYTFNVEAQNGVSGLGSSGHASTSVSISMGHAESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLTYELHVLNQDEERYQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPGPFSPDHEFRTSPPVSRGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRDRATDVDREDKLWLKPYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIANFDPRMTLRLPSLSGSDGIPYRTVSEWLESIRMKRYILHFHSAGLDTMECVLELTAEDLTQMGITLPGHQKRILCSIQGFKD

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P21709-1; Sequence=Displayed; Name=2; IsoId=P21709-2; Sequence=VSP_056010, VSP_056013; Name=3; IsoId=P21709-3; Sequence=VSP_056011, VSP_056012

Alternative Sequence

446..490; ESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLTYELHVLNQDE -> DPTLSLWTPRVTVRPVSETGEERTEATRADLGGVPAPKPWGEPDL (in isoform 2); 446..474; ESLSGLSLRLVKKEPRQLELTWAGSRPRS -> GERLRGAGTGTWWRQKGLRPQNKLMGRKP (in isoform 3); 475..976; Missing (in isoform 3); 491..976; Missing (in isoform 2)

3D Structural Models

Helix

545..570; 918..924; 928..930; 931..936; 942..945; 950..955; 961..973

Beta Strand

538..540

3D Structure

NMR spectroscopy (2); X-ray crystallography (2)

Domain & Motif Annotations

Motif

974..976; PDZ-binding

Domain (FT)

27..209; Eph LBD; 332..445; Fibronectin type-III 1; 447..538; Fibronectin type-III 2; 624..884; Protein kinase; 913..976; SAM

Protein Families (3)

Protein kinase superfamily
Tyr protein kinase family
Ephrin receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

Clinical Relevance3

Disease Involvement

Cancer-related genes

Drugs (2)

COMPOUND 22 [PMID: 21823616]VANDETANIB

Antibody

CAB026144

Supporting Publications3

PMID	Title	Abstract
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available