Protein detail
EPHA1
Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
Protein symbol EPHA1 | UniProt ID | EVMP score 0.25 |
Frequency 3 | Transmembrane count 1 | Protein classification Cancer-related genesEnzymesPlasma proteinsPredicted membrane proteins |
Basic Information
Protein Names
Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
Protein Class
Cancer-related genesEnzymesPlasma proteinsPredicted membrane proteins
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:Tyr protein kinases
Transmembrane
548..568; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
EPHEPHTEPHT1
Gene Description
EPH receptor A1
Chromosome
7
Position
143390289-143408856
Frequency
3
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificliverCell SpecificEndometrial luminal cells
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:Tyr protein kinases
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-3928663 epha mediated growth cone collapse
- R-hsa-3928665 eph ephrin mediated repulsion of cells
- R-hsa-2682334 eph ephrin signaling
- R-hsa-9675108 nervous system development
- R-hsa-2892247 pou5f1 oct4 sox2 nanog activate genes related to proliferation
- R-hsa-452723 transcriptional regulation of pluripotent stem cells
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
62 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | Baccin2019 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| EFNA1 | P20827 | EPHA1 | P21709 | Yes | Yes | No | iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:9330863Cellinker:15114347SIGNOR:9576626Baccin2019:9330863connectomeDB2020:11519828connectomeDB2020:8755474Cellinker:11519828SignaLink3:11519828SignaLink3:8755474Cellinker:8755474SignaLink3:18988627LRdb:11114742CellChatDB:15114347SignaLink3:23331499HPRD:11519828connectomeDB2020:9330863Baccin2019:8755474HPMR:9330863ICELLNET:24003208HPRD:8755474SIGNOR:9330863Baccin2019:11519828ICELLNET:15114347SignaLink3:9267020 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
976
Mass
108,127
Sequence
MERRWPLGLGLVLLLCAPLPPGARAKEVTLMDTSKAQGELGWLLDPPKDGWSEQQQILNGTPLYMYQDCPMQGRRDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKETFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLVSGSVKLNVERCSLGRLTRRGLYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTLPGPAGLVEVAGTCLPHARASPRPSGAPRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEACVACPSGSYRMDMDTPHCLTCPQQSTAESEGATICTCESGHYRAPGEGPQVACTGPPSAPRNLSFSASGTQLSLRWEPPADTGGRQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHFSPGARGLTTPAVHVNGLEPYANYTFNVEAQNGVSGLGSSGHASTSVSISMGHAESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLTYELHVLNQDEERYQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPGPFSPDHEFRTSPPVSRGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRDRATDVDREDKLWLKPYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIANFDPRMTLRLPSLSGSDGIPYRTVSEWLESIRMKRYILHFHSAGLDTMECVLELTAEDLTQMGITLPGHQKRILCSIQGFKD
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P21709-1; Sequence=Displayed; Name=2; IsoId=P21709-2; Sequence=VSP_056010, VSP_056013; Name=3; IsoId=P21709-3; Sequence=VSP_056011, VSP_056012
Alternative Sequence
446..490; ESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLTYELHVLNQDE -> DPTLSLWTPRVTVRPVSETGEERTEATRADLGGVPAPKPWGEPDL (in isoform 2); 446..474; ESLSGLSLRLVKKEPRQLELTWAGSRPRS -> GERLRGAGTGTWWRQKGLRPQNKLMGRKP (in isoform 3); 475..976; Missing (in isoform 3); 491..976; Missing (in isoform 2)
3D Structural Models
Helix
545..570; 918..924; 928..930; 931..936; 942..945; 950..955; 961..973
Beta Strand
538..540
3D Structure
NMR spectroscopy (2); X-ray crystallography (2)
Domain & Motif Annotations
Motif
974..976; PDZ-binding
Domain (FT)
27..209; Eph LBD; 332..445; Fibronectin type-III 1; 447..538; Fibronectin type-III 2; 624..884; Protein kinase; 913..976; SAM
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- Ephrin receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.