Protein detail

TA2R

Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)

Entry name TA2R	UniProt ID P21731	EVMP score 0.50
Frequency 1	Transmembrane count 7	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)

Protein Function

Disease related genes
Human disease related genes:Cardiovascular diseases:Hematologic diseases
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

30..52; Helical; Name=1; 67..87; Helical; Name=2; 107..128; Helical; Name=3; 150..172; Helical; Name=4; 194..219; Helical; Name=5; 247..270; Helical; Name=6; 290..311; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000006638

Entrez Gene Symbol

TBXA2R

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificlungCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificcentral nervous system macrophageSecretome LocationSecreted in other tissuesSecretome FunctionReceptor

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Cardiovascular diseases:Hematologic diseases
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M65 Pid fra pathway
M255 Pid hif1 tfpathway

Mediation Categories

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

31 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TBXA2R	PRKACA	P17612	S	331	phosphorylation	SIGNOR_ProtMapperPhosphoSiteSIGNORProtMapper	SIGNOR:12147288 ProtMapper:12147288
TBXA2R	PRKACA	P17612	T	332	phosphorylation	MIMPPhosphoSitePhosphoSite_MIMP
TBXA2R	PRKACA	P17612	S	330	phosphorylation	MIMPPhosphoSitePhosphoSite_MIMP
TBXA2R	PRKACA	P17612	S	324	phosphorylation	PhosphoSite
TBXA2R	PRKACA	P17612	S	329	phosphorylation	NCI-PID_ProtMapperProtMapperKEAPhosphoSitePhosphoSite_ProtMapper	ProtMapper:11389883 KEA:11749379 ProtMapper:7961988 ProtMapper:10827090
TBXA2R	PRKG1	Q13976	T	332	phosphorylation	MIMPPhosphoSitePhosphoSite_MIMP
TBXA2R	PRKG1	Q13976	S	330	phosphorylation	MIMPPhosphoSitePhosphoSite_MIMP
TBXA2R	PRKG1	Q13976	S	331	phosphorylation	NCI-PID_ProtMapperPhosphoSiteProtMapper	ProtMapper:17466390 ProtMapper:11516166 ProtMapper:9560198 ProtMapper:14530262 ProtMapper:9915793
TBXA2R	PRKG1	Q13976	T	337	phosphorylation	NCI-PID_ProtMapperProtMapper	ProtMapper:17466390 ProtMapper:11516166 ProtMapper:9560198 ProtMapper:14530262 ProtMapper:9915793
TBXA2R	GRK2	P25098	S	357	phosphorylation	MIMPPhosphoSitePhosphoSite_MIMP

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Ligand-Receptor Signaling

57 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No

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Regulatory Interaction Network

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ARBK2	P35626	TA2R	P21731	Yes	No	Yes	PhosphoSite_MIMPMIMPNCI-PID_ProtMapperiPTMnetSIGNORProtMapperWang	SIGNOR:16956790 ProtMapper:10085139
TA2R	P21731	GNA13	Q14344	Yes	Yes	Yes	SIGNORHPRDHINTBioGRIDWangLit-BM-17	BioGRID:10488151 SIGNOR:31160049 Lit-BM-17:12399457 Lit-BM-17:10488151 Lit-BM-17:8290554 HINT:15782186 HPRD:10395940 Lit-BM-17:15782186 HPRD:8290554 HINT:12399457
TA2R	P21731	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:31160049
ARBK1	P25098	TA2R	P21731	Yes	No	Yes	PhosphoSite_MIMPMIMPNCI-PID_ProtMapperPhosphoSite_norefSIGNORiPTMnetProtMapperWangPhosphoSite	PhosphoSite:16956790 SIGNOR:16956790 ProtMapper:10085139
TA2R	P21731	GNAQ	P50148	Yes	Yes	No	SIGNORHPRDHINTBioGRIDLit-BM-17	BioGRID:12726995 Lit-BM-17:15134434 SIGNOR:31160049 HPRD:9152406 Lit-BM-17:20590159 Lit-BM-17:12399457 HPRD:12193606 HINT:15782186 HINT:20590159 BioGRID:23962128 Lit-BM-17:21940795 Lit-BM-17:23962128 Lit-BM-17:12726995 Lit-BM-17:15782186 HINT:12399457
KPCA	P17252	TA2R	P21731	Yes	No	Yes	PhosphoSite_MIMPMIMPNCI-PID_ProtMapperPhosphoSite_norefSIGNORiPTMnetProtMapperHINTBioGRIDWangPhosphoSitePhosphoSite_ProtMapper	ProtMapper:15100160 BioGRID:12370102 ProtMapper:9054415 PhosphoSite:18578522 ProtMapper:9560198 SIGNOR:16956790 BioGRID:11504827 ProtMapper:16956790 HINT:11504827 HINT:12370102 ProtMapper:11015313 ProtMapper:14530262 PhosphoSite:12370102 ProtMapper:11516166 PhosphoSite:17466390 PhosphoSite:15100160 ProtMapper:9915793 PhosphoSite:24490858 ProtMapper:17466390 ProtMapper:7961988 PhosphoSite:10827090
TA2R	P21731	GNA14	O95837	Yes	Yes	No	SIGNOR	SIGNOR:31160049
KAPCA	P17612	TA2R	P21731	Yes	No	Yes	WangPhosphoSite_MIMPMIMPNCI-PID_ProtMapperPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSite_KEAKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:12147288 ProtMapper:11389883 ProtMapper:10827090 PhosphoSite:14530262 PhosphoSite:12147288 KEA:11749379 ProtMapper:7961988 ProtMapper:12147288

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

343

Mass

37,431

Sequence

MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha, Placenta receptor; IsoId=P21731-3; Sequence=Displayed; Name=2; Synonyms=Beta, Endothelial receptor; IsoId=P21731-2; Sequence=VSP_001925

Alternative Sequence

329..343; SLSLQPQLTQRSGLQ -> RSLTLWPSLEYSGTISAHCNLRLPGSSDSRASASRAAGITGVSHCARPCMLFDPEFDLLAGVQLLPFEPPTGKALSRKD (in isoform 2)

3D Structural Models

Turn

19..25; 28..32; 137..139; 308..311

Helix

33..55; 63..90; 95..98; 104..135; 146..164; 167..169; 191..226; 229..234; 239..269; 284..298; 300..307; 313..319

Beta Strand

174..176; 183..185

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Related Diseases

Angina pectoris Arterial occlusive disease Asthma Cardiovascular disease Chronic arterial occlusive disease Coronary atherosclerosis Diabetic foot ulcer Myocardial infarction Neuropathy Sexual dysfunction Solid tumour/cancer Thrombosis Vasomotor/allergic rhinitis

Biomarker

Phase 2; Discontinued in Phase 3; Terminated; Phase 1; Phase 4; Approved; Clinical trial; Phase 2/3

Drugs

DINOPROST NULL VINBLASTINE TERBOGREL IFETROBAN SODIUM CYCLOSPORINE FUROSEMIDE TERUTROBAN RAMATROBAN RIDOGREL SERATRODAST PICOTAMIDE PAREGORIC ALPROSTADIL LAROPIPRANT

Interaction Protein

ENSG00000123131

Interaction Count

Interaction Dataset

intact_biogrid