EV MemProt Atlas

Basic Information

Protein Names

Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)

Protein Class

Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins

Protein Function

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Cancers:Cancers of the digestive system
Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
CD markers
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Human disease related genes:Congenital malformations:Other congenital malformations
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs
FDA approved drug targets:Biotech drugs

Transmembrane

378..398; Helical

Transmembrane Count

1

Ensembl

ENSG00000066468

Entrez Gene Symbol

FGFR2

Gene Synonym

BEKCD332CEK3CFD1ECT1JWSK-SAMKGFRTK14TK25

Gene Description

Fibroblast growth factor receptor 2

Chromosome

10

Position

121478332-121598458

Frequency

1

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBrain excitatory neuronsBlood Cell Specificplasmacytoid DC

Function & Pathway

Protein Function

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Cancers:Cancers of the digestive system
Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
CD markers
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Human disease related genes:Congenital malformations:Other congenital malformations
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M56 Pid lpa4 pathway
M8 Pid endothelin pathway
M15 Pid lysophospholipid pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

5 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
FGFR2	PRKCE	Q02156	S	782	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:23564461 ProtMapper:23564461
FGFR2	MAPK3	P27361	S	780	phosphorylation	PhosphoSite
FGFR2	MAPK1	P28482	S	780	phosphorylation	PhosphoSite
FGFR2	FGF2	P09038	S	780	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:18332103
FGFR2	FGFR1	P11362	Y	769	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

61 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	talklr	No	Yes	Yes	Yes	No
receptor	receptor	Cellinker	No	Yes	Yes	Yes	No
receptor	receptor	scConnect	No	Yes	Yes	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	Yes	Yes	No
receptor	receptor	CellCall	No	Yes	Yes	Yes	No
receptor	receptor	iTALK	No	Yes	Yes	Yes	No
growth_factor	receptor	iTALK	No	Yes	Yes	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	Yes	Yes	No
tyrosine_kinase	receptor	HGNC	No	Yes	Yes	Yes	No
receptor	receptor	HGNC	No	Yes	Yes	Yes	No

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Regulatory Interaction Network

20 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FGF18	O76093	FGFR2	P21802	Yes	Yes	No	iTALKICELLNETSIGNORSignaLink3CellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPRD_talklrCellinkerCellCallCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	CellTalkDB:16597617 Cellinker:10751172 Cellinker:25772309 ICELLNET:25772309 SIGNOR:8663044 SignaLink3:23331499 SignaLink3:8663044 connectomeDB2020:10751172 LRdb:16597617 HPRD:10751172
FGF22	Q9HCT0	FGFR2	P21802	Yes	Yes	No	CellChatDBCellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrICELLNETRamilowski2015Reactome_LRdbconnectomeDB2020SignaLink3CellinkerWangLRdbCellCallHPMR_talklr	CellTalkDB:16597617 Cellinker:25772309 ICELLNET:25772309 connectomeDB2020:12591959 SignaLink3:23331499 Cellinker:12591959 Cellinker:16597617 SignaLink3:8663044 LRdb:16597617
PTN11	Q06124	FGFR2	P21802	Yes	No	Yes	WangSIGNOR	SIGNOR:23420874
FGFR2	P21802	GRB2	P62993	Yes	Yes	No	KEGG-MEDICUSiPTMnetSIGNORProtMapperREACH_ProtMapperRLIMS-P_ProtMapperHINTIntActInnateDBWangLit-BM-17PhosphoSitePhosphoSite_ProtMapper	PhosphoSite:20554525 InnateDB:19735729 ProtMapper:26103942 PhosphoSite:26103942 PhosphoSite:33795832 HINT:22726438 HINT:24440983 IntAct:22726438 SIGNOR:22726438 Lit-BM-17:22726438 ProtMapper:23420874 HINT:19735729
FGF5	P12034	FGFR2	P21802	Yes	Yes	No	iTALKICELLNETSIGNORHPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrCellinkerCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	connectomeDB2020:11876253 CellTalkDB:16597617 Cellinker:25772309 connectomeDB2020:8386828 ICELLNET:25772309 HPRD:11876253 SIGNOR:8386828 Cellinker:16597617 LRdb:16597617 Cellinker:8386828 Cellinker:11876253
FGFR2	P21802	LGUL	Q04760	Yes	Yes	No	SIGNOR	SIGNOR:34838714
KPCE	Q02156	FGFR2	P21802	Yes	Yes	Yes	Sparser_ProtMapperiPTMnetSIGNORProtMapperACSNSIGNOR_ProtMapper	ACSN:11313945 ACSN:15567848 ProtMapper:23564461 ACSN:11940581 ACSN:17496910 ACSN:14585353 ACSN:21386996 SIGNOR:23564461 ACSN:19568798 ACSN:19615955 ACSN:16488589 ACSN:6321473 ACSN:12845332 ACSN:12040186 ACSN:8321321 ProtMapper:31146385 ACSN:11447289
FGFR2	P21802	FRS2	Q8WU20	Yes	Yes	Yes	WangCui2007SIGNORACSN	ACSN:15567848 ACSN:15574420 ACSN:17496910 ACSN:14585353 ACSN:15173823 ACSN:12040186 ACSN:19568798 SIGNOR:9182757 ACSN:16488589 ACSN:6321473 ACSN:11997436 ACSN:11274345 ACSN:11777939 ACSN:11447289
ADAM9	Q13443	FGFR2	P21802	Yes	No	Yes	SIGNOR	SIGNOR:22632802
MK03	P27361	FGFR2	P21802	Yes	No	Yes	WangPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:31146385

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Protein Complex Composition

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
FGF10 FGFR2	O15520 P21802	1:1	PDB	PDB:1nun
FGF1 FGFR2	P05230 P21802	2:2	PDB	PDB:4j23PDB:1e0oPDB:3ojmPDB:3cu1PDB:3oj2PDB:1djs
FGF2 FGFR2	P09038 P21802	4:4	PDB	PDB:1ii4PDB:1ev2PDB:1iil
FGFR2	P21802	2	PDB	PDB:5ugxPDB:6lvlPDB:8e1xPDB:7ozyPDB:2pzpPDB:8stgPDB:4j96PDB:4j99PDB:2pz5PDB:8w38PDB:2psqPDB:5uhnPDB:7kiePDB:8u1fPDB:6v6qPDB:4wv1PDB:4j97PDB:3euuPDB:4j95PDB:3darPDB:9u3nPDB:8h75PDB:8w3bPDB:3ri1PDB:3b2tPDB:8w3dPDB:6lvkPDB:5uglPDB:8swePDB:2py3PDB:2pvfPDB:8w2xPDB:6agxPDB:7kiaPDB:2pzrPDB:2pvyPDB:2pwlPDB:5ui0PDB:4j98PDB:2q0b
FGF8 FGFR2	P21802 P55075	2:2	PDB	PDB:2fdb
C8orf74 FGFR2 MORN2	P21802 Q502X0 Q6P047	0:0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	27863537

Sequence, Structure & Domains

Sequences

Length

821

Mass

92,025

Sequence

MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT

Alternative Products

Event=Alternative splicing; Named isoforms=17; Name=1; Synonyms=BEK, FGFR2IIIc; IsoId=P21802-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P21802-2; Sequence=VSP_002978; Name=3; Synonyms=BFR-1, FGFR2IIIb, KGFR; IsoId=P21802-3; Sequence=VSP_002969, VSP_002970, VSP_002971, VSP_002972; Name=4; Synonyms=K-sam; IsoId=P21802-4; Sequence=VSP_002964, VSP_002969, VSP_002970, VSP_002971, VSP_002972, VSP_002975, VSP_002976; Name=5; Synonyms=K-sam-I, BEK, IgIIIc; IsoId=P21802-5; Sequence=VSP_002975; Name=6; Synonyms=K-sam-IIC2; IsoId=P21802-6; Sequence=VSP_002975, VSP_002984; Name=7; Synonyms=K-sam-IIC3; IsoId=P21802-8; Sequence=VSP_002975, VSP_002978; Name=8; Synonyms=K-sam-IV, Soluble KGFR; IsoId=P21802-14; Sequence=VSP_002965, VSP_002966; Name=9; Synonyms=K-sam-III; IsoId=P21802-15; Sequence=VSP_002968; Name=10; Synonyms=TK14; IsoId=P21802-16; Sequence=VSP_002967, VSP_002975; Name=11; IsoId=P21802-17; Sequence=VSP_002969, VSP_002970, VSP_002971, VSP_002972, VSP_002978; Name=12; Synonyms=K-sam-IIC1, KGFR, IgIIIb; IsoId=P21802-18; Sequence=VSP_002969, VSP_002970, VSP_002971, VSP_002972, VSP_002975; Name=13; Synonyms=Soluble KGFR; IsoId=P21802-19; Sequence=VSP_002969, VSP_002970, VSP_002971, VSP_002972, VSP_002973, VSP_002974; Name=14; IsoId=P21802-20; Sequence=VSP_019608, VSP_019609; Name=15; IsoId=P21802-21; Sequence=VSP_002964, VSP_041915; Name=16; IsoId=P21802-22; Sequence=VSP_002964, VSP_002969, VSP_002970, VSP_002971, VSP_002972, VSP_002978; Name=17; IsoId=P21802-23; Sequence=VSP_041914

Alternative Sequence

37..152; EPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR -> G (in isoform 14); 37..125; Missing (in isoform 4, isoform 15 and isoform 16); 250..361; Missing (in isoform 17); 250..254; ERSPH -> GSQGL (in isoform 8); 255..821; Missing (in isoform 8); 313; K -> KVTK (in isoform 10); 314..429; Missing (in isoform 9); 314..330; AAGVNTTDKEIEVLYIR -> HSGINSSNAEVLALF (in isoform 3, isoform 4, isoform 11, isoform 12, isoform 13 and isoform 16); 334..335; FE -> EA (in isoform 3, isoform 4, isoform 11, isoform 12, isoform 13 and isoform 16); 341..353; TCLAGNSIGISFH -> ICKVSNYIGQANQ (in isoform 3, isoform 4, isoform 11, isoform 12, isoform 13 and isoform 16); 361; P -> PKQQ (in isoform 3, isoform 4, isoform 11, isoform 12, isoform 13 and isoform 16); 362..365; APGR -> GRRC (in isoform 13); 366..821; Missing (in isoform 13); 428..429; Missing (in isoform 4, isoform 5, isoform 6, isoform 7, isoform 10 and isoform 12); 429..430; Missing (in isoform 14); 761..821; LTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT -> PPNPSLMSIFRK (in isoform 4); 768..821; EYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT -> I (in isoform 2, isoform 7, isoform 11 and isoform 16); 769..821; YLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT -> EKKVSGAVDCHKPPCNPSHLPCVLAVDQ (in isoform 15); 778..821; QYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT -> PYSPCYPDPR (in isoform 6)

3D Structural Models

Turn

159..162; 463..465; 472..474; 490..492; 585..588; 636..638; 652..654; 659..662

Helix

200..202; 211..213; 223..225; 321..323; 334..336; 478..480; 525..541; 572..577; 590..592; 594..596; 600..619; 629..631; 645..647; 667..669; 672..677; 682..697; 709..718; 730..739; 744..746; 750..764

Beta Strand

152..157; 166..170; 175..178; 181..185; 188..193; 203..205; 208..210; 215..218; 227..235; 238..249; 266..269; 274..277; 287..293; 296..298; 299..301; 303..305; 309..314; 315..319; 324..327; 338..346; 349..360; 481..489; 494..500; 504..506; 513..518; 550..554; 556..558; 561..565; 568..571; 632..634; 640..642; 655..658; 664..666; 726..728

3D Structure

NMR spectroscopy (1); X-ray crystallography (56)

Domain & Motif Annotations

Compositional Bias

131..144; Acidic residues

Domain (CC)

The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. Alternative splicing events affecting the third Ig-like domain are crucial for ligand selectivity.

Domain (FT)

25..125; Ig-like C2-type 1; 154..247; Ig-like C2-type 2; 256..358; Ig-like C2-type 3; 481..770; Protein kinase

Region

131..151; Disordered; 161..178; Heparin-binding

Protein Families

Protein kinase superfamily
Tyr protein kinase family
Fibroblast growth factor receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesCraniosynostosisDisease variantEctodermal dysplasiaFDA approved drug targetsIntellectual disabilityLacrimo-auriculo-dento-digital syndromeProto-oncogene

Related Diseases

Alzheimer disease Bladder cancer Breast cancer Hepatitis virus infection Liver cancer Myeloproliferative neoplasm Oral mucositis Periodontal disease Retina cancer Solid tumour/cancer Stomach cancer

Biomarker

Phase 1/2; Phase 2; Approved; Phase 3; Terminated; Phase 1

Drug Targets

FDA approved drug targets

Drugs

S-49076 INAVOLISIB XL228 NINTEDANIB ESYLATE DOVITINIB FEXAGRATINIB NULL OLVEREMBATINIB ALPELISIB NAVITOCLAX BRIVANIB DERAZANTINIB PD173074 ORANTINIB PALIFERMIN BEMARITUZUMAB RABEPRAZOLE TG100-801 PEGINTERFERON ALFA-2A INFIGRATINIB HMPL-453 MUPARFOSTAT FUTIBATINIB MK-2461 FGFR INHIBITOR CPL304110 RG-1530 SUNITINIB ERDAFITINIB CETRELIMAB AKT INHIBITOR MK2206 TINENGOTINIB ZOTATIFIN VEMURAFENIB FGFR INHIBITOR DEBIO 1347 TASURGRATINIB PONATINIB ENMD-2076 TRAFERMIN PICTILISIB ENMD-981693 REGORAFENIB KIN-3248 BUPARLISIB MASITINIB PAZOPANIB AEE-788 ABT-737 APRUTUMAB IXADOTIN ZOLIGRATINIB XL999 LY2874455 FPA144 LUCITANIB TRAMETINIB DIMETHYL SULFOXIDE PEMIGATINIB INFIGRATINIB PHOSPHATE AZD-4547 FULVESTRANT VARGATEF FGFR1/2/3 INHIBITOR TYRA-200 FP-1039 THALIDOMIDE MEK INHIBITOR RO4987655 LENVATINIB SELUMETINIB ROGARATINIB ALOFANIB APRUTUMAB FGFR/CSF-1R INHIBITOR 3D185 LY-2874455 LIRAFUGRATINIB OXALIPLATIN PRN1371 ODM-203 CP-459632 AVUTOMETINIB TRABECTEDIN FGF RECEPTOR ANTAGONIST HGS1036 TEMUTERKIB CEDIRANIB XL-999 GUNAGRATINIB LEUCOVORIN CALCIUM PHA-665752 BRIVANIB ALANINATE FLUOROURACIL

Antibody

CAB010886 HPA035305

Interaction Protein

ENSG00000070193ENSG00000077782ENSG00000113578ENSG00000138685ENSG00000179295

Interaction Count

5

Interaction Dataset

intact_biogrid

Protein symbol FGFR2	UniProt ID P21802	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins