EV MemProt Atlas

Basic Information

Protein Names

Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)

Protein Class

Cancer-related genesDisease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters

Protein Function

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
Human disease related genes:Endocrine and metabolic diseases:Diabetes
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
Potential drug targets
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Transporters:Accessory Factors Involved in Transport
Kinases:Tyr protein kinases
Disease related genes

Transmembrane

644..664; Helical

Transmembrane Count

1

Ensembl

ENSG00000065361

Entrez Gene Symbol

ERBB3

Gene Synonym

HER3LCCS2

Gene Description

Erb-b2 receptor tyrosine kinase 3

Chromosome

12

Position

56076799-56103505

Frequency

1

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificheart muscleBrain Regional SpecificmidbrainCell SpecificT-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificT-cells

Function & Pathway

Protein Function

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
Human disease related genes:Endocrine and metabolic diseases:Diabetes
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
Potential drug targets
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Transporters:Accessory Factors Involved in Transport
Kinases:Tyr protein kinases
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

18 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ERBB3	ERBB2	P04626	Y	1,199	phosphorylation	KEA	KEA:17570479
ERBB3	HRG	P04196	Y	1,289	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:26148232
ERBB3	HRG	P04196	S	686	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:24036211
ERBB3	ROR1	Q01973	Y	1,307	phosphorylation	RLIMS-P_ProtMapperREACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:28114269
ERBB3	RORA	P35398	Y	1,307	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:28114269
ERBB3	FYN	P06241	Y	1,262	phosphorylation	KEA	KEA:17570479
ERBB3	INSR	P06213	Y	1,262	phosphorylation	KEA	KEA:17570479
ERBB3	LCK	P06239	Y	1,199	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling

77 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
growth_factor_neuregulin	receptor	ICELLNET	No	Yes	Yes	Yes	No
growth_factor_egfr_family	receptor	ICELLNET	No	Yes	Yes	Yes	No
receptor	receptor	OmniPath	No	Yes	Yes	Yes	No
extracellular	extracellular	HPMR	No	No	Yes	Yes	No
extracellular	extracellular	OmniPath	No	No	Yes	Yes	No
intracellular	intracellular	LOCATE	No	No	Yes	Yes	No
intracellular	intracellular	ComPPI	No	No	Yes	Yes	No
intracellular	intracellular	GO_Intercell	No	No	Yes	Yes	No
intracellular	intracellular	OmniPath	No	No	Yes	Yes	No
growth_factor_binder	ligand_regulator	GO_Intercell	Yes	No	Yes	Yes	No

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Regulatory Interaction Network

17 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EGFR	P00533	ERBB3	P21860	Yes	Yes	No	WangiPTMnetPhosphoPointSIGNORProtMapperHPRDCui2007HINTBioGRIDIntActLi2012SIGNOR_ProtMapperLit-BM-17SPIKESPIKE_LC	Lit-BM-17:10527633 HINT:23866081 Lit-BM-17:23436906 IntAct:10572067 Lit-BM-17:18803307 SPIKE_LC:17145710 BioGRID:27756321 SPIKE:17145710 HINT:17148612 SPIKE_LC:12648464 ProtMapper:7929151 HINT:24189400 SPIKE_LC:10572067 IntAct:35512704 HINT:10572067 HINT:21278786 IntAct:23866081 HINT:25315821 Lit-BM-17:24189400 SPIKE:12648464 Lit-BM-17:22439932 IntAct:17148612 HINT:22439932 BioGRID:10527633 IntAct:21278786 IntAct:23436906 Lit-BM-17:10572067 HINT:25468994 HPRD:10527633 HINT:31862538 SPIKE:10572067 SIGNOR:7929151
ERBB2	P04626	ERBB3	P21860	Yes	Yes	No	WangSparser_ProtMapperPhosphoPointSIGNORProtMapperREACH_ProtMapperHPRDHINTRLIMS-P_ProtMapperKEABioGRIDSignaLink3IntActCellinkerSPIKE_LCLit-BM-17NetworKIN_KEA	HINT:23866081 HINT:8665853 IntAct:10572067 Lit-BM-17:23436906 SPIKE_LC:17145710 HINT:16843263 HINT:34759323 HINT:17148612 Lit-BM-17:19411071 Lit-BM-17:21075308 SIGNOR:23912457 BioGRID:15504738 SPIKE_LC:10572067 IntAct:23688700 ProtMapper:29066975 HINT:10572067 HINT:21278786 IntAct:25241761 IntAct:20227043 IntAct:21203579 IntAct:24557338 HINT:25315821 IntAct:17426253 SIGNOR:12648465 HPRD:7538656 Lit-BM-17:22806884 HINT:20227043 HINT:25326665 IntAct:23680147 Cellinker:30898150 SIGNOR:8816440 IntAct:19411071 Lit-BM-17:23688700 HINT:17426253 IntAct:17148612 Lit-BM-17:23680147 HPRD:10799311 Lit-BM-17:20227043 Lit-BM-17:15504738 HINT:21075308 SignaLink3:12648465 ProtMapper:27531070 Lit-BM-17:19060928 SignaLink3:23331499 HINT:21203579 HINT:7592681 IntAct:21278786 IntAct:23436906 Lit-BM-17:25241761 IntAct:22806884 Lit-BM-17:10572067 ProtMapper:31752936 HPRD:11173924 IntAct:22733765 Lit-BM-17:9130710 HINT:19411071 Lit-BM-17:17426253 Lit-BM-17:24557338 HINT:22733765 HINT:31862538 Lit-BM-17:7592681 KEA:17570479 Lit-BM-17:16843263 ProtMapper:17003495 HINT:30898150 HINT:8816440
LRIG1	Q96JA1	ERBB3	P21860	Yes	Yes	Yes	SIGNORSignaLink3	SignaLink3:16123311 SignaLink3:23331499 SIGNOR:16123311
ERBB3	P21860	P85A	P27986	Yes	Yes	No	DOMINOWangPhosphoPointHPRDCui2007HINTSignaLink3BioGRIDACSNIntActSPIKE_LCLit-BM-17	Lit-BM-17:10383151 HINT:20007781 Lit-BM-17:18803287 HINT:10383151 IntAct:10572067 SPIKE_LC:16273093 SPIKE_LC:17145710 SignaLink3:11546794 HINT:22973453 IntAct:16273093 BioGRID:11694521 Lit-BM-17:21075308 ACSN:17496910 SPIKE_LC:10572067 HINT:10572067 HINT:21278786 IntAct:20227043 Lit-BM-17:9756944 Lit-BM-17:24189400 HINT:20227043 SignaLink3:18988627 Lit-BM-17:22439932 HINT:22439932 Lit-BM-17:20227043 DOMINO:16273093 HINT:21075308 Lit-BM-17:11546794 BioGRID:10383151 SignaLink3:23331499 HPRD:11546794 HINT:11546794 SignaLink3:21071413 HPRD:10383151 IntAct:21278786 Lit-BM-17:16273093 SignaLink3:10383151 Lit-BM-17:10572067 IntAct:20007781 Lit-BM-17:9130710 Lit-BM-17:20007781
NRG2	O14511	ERBB3	P21860	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTSignaLink3HPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	CellTalkDB:9168115 HPMR:9168115 HINT:15358134 HPRD:9168115 connectomeDB2020:9168115 SIGNOR:7514177 connectomeDB2020:9168114 LRdb:9168115 SignaLink3:9168114 HINT:9168115 ICELLNET:9168115 SignaLink3:9168115LRdb:917SignaLink3:23331499 HPRD:9168114
NRG1	Q02297	ERBB3	P21860	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETProtMapperSIGNORHINTSignaLink3DIPLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbtalklrscConnectHPRDIntActDLRP_talklrWangRamilowski2015BEL-Large-Corpus_ProtMapperHPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDREACH_ProtMapperSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb	Lit-BM-17:17697999 HINT:30523157 LRdb:11555649 LRdb:8702572 SignaLink3:11555649 connectomeDB2020:11555649 ICELLNET:10214951 connectomeDB2020:9565587 ProtMapper:16843264 ProtMapper:26148232 connectomeDB2020:8702572 LRdb:9565587 HINT:34759323 LRdb:7514177 HINT:11389077 SIGNOR:7477375 HINT:11555649 HPRD:9565587 DIP:17697999 Lit-BM-17:10970856 Lit-BM-17:11555649 HPRD:8702572 HINT:37398436 IntAct:7592681 HINT:10970856 HINT:10913256 HPRD:11555649 SignaLink3:23331499 connectomeDB2020:7514177 HINT:33961781 BioGRID:7592681 HINT:7592681 CellTalkDB:7514177 connectomeDB2020:7592681 LRdb:7592681 SignaLink3:9275162 SIGNOR:7514177 HINT:9168115 HPRD:7592681 Lit-BM-17:7592681 Lit-BM-17:9168115 SPIKE_LC:16189514
ANDR	P10275	ERBB3	P21860	Yes	Yes	No	SignaLink3	SignaLink3:15542423 SignaLink3:23331499
ERBB3	P21860	GRB2	P62993	Yes	Yes	No	DOMINOWangPhosphoPointSIGNORHPRDHINTIntActSPIKE_LCLit-BM-17	HINT:16729043 SIGNOR:16729043 HINT:24658140 SIGNOR:14967450 IntAct:16729043 Lit-BM-17:16729043 HPRD:11173924 IntAct:24658140 Lit-BM-17:9756944 Lit-BM-17:24189400 HPRD:16729043 SPIKE_LC:16729043 DOMINO:16729043 Lit-BM-17:24658140
ROR1	Q01973	ERBB3	P21860	Yes	Yes	No	Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapper	ProtMapper:28114269 SIGNOR:22439932
ERBB3	P21860		COMPLEX:P27986_P42336	Yes	Yes	No	SIGNOR	SIGNOR:16729043

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Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ERBB3	P21860	2	PDB	PDB:1m6bPDB:3kexPDB:7bhfPDB:3lmgPDB:7bhePDB:6kbiPDB:2l9uPDB:7d85
	ERBB3 S6B291	P21860 S6B291	4:4	PDB	PDB:5cus

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

1,342

Mass

148,098

Sequence

MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=long form; IsoId=P21860-1; Sequence=Displayed; Name=2; Synonyms=short form; IsoId=P21860-2; Sequence=VSP_002893, VSP_002894; Name=3; IsoId=P21860-3; Sequence=VSP_041663, VSP_041664; Name=4; IsoId=P21860-4; Sequence=VSP_041662; Name=5; IsoId=P21860-5; Sequence=VSP_041661

Alternative Sequence

1..643; Missing (in isoform 5); 1..59; Missing (in isoform 4); 141..183; EILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSC -> GQFPMVPSGLTPQPAQDWYLLDDDPRLLTLSASSKVPVTLAAV (in isoform 2); 184..1342; Missing (in isoform 2); 331; C -> F (in isoform 3); 332..1342; Missing (in isoform 3)

3D Structural Models

Turn

112..114; 158..160; 267..269; 345..347; 372..375; 425..427; 747..749; 870..872; 911..914; 952..954

Helix

43..53; 75..79; 163..166; 188..190; 199..201; 223..225; 240..242; 348..351; 365..369; 381..389; 410..412; 465..467; 470..474; 490..495; 514..516; 626..628; 641..670; 706..708; 758..764; 795..802; 803..806; 808..827; 837..839; 856..858; 865..868; 875..877; 880..885; 890..905; 917..919; 920..925; 938..947; 958..969; 972..974

Beta Strand

28..30; 38..41; 58..61; 63..67; 82..85; 87..91; 95..98; 115..120; 125..128; 133..135; 141..144; 146..150; 174..178; 194..198; 214..216; 218..222; 231..233; 235..239; 243..251; 254..258; 262..265; 270..274; 280..282; 285..289; 295..297; 300..304; 309..314; 317..322; 324..326; 330..332; 338..342; 355..363; 392..395; 397..399; 428..433; 451..457; 481..488; 509..513; 517..522; 528..531; 534..540; 542..545; 548..551; 560..562; 564..569; 572..581; 584..588; 591..595; 598..604; 608..612; 621..625; 709..717; 722..728; 731..733; 737..744; 753..755; 774..778; 780..788; 840..846; 848..850; 980..983

3D Structure

Electron microscopy (4); NMR spectroscopy (1); X-ray crystallography (17)

Domain & Motif Annotations

Compositional Bias

1042..1075; Polar residues

Domain (CC)

The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.

Domain (FT)

709..966; Protein kinase

Region

980..999; Disordered; 1033..1152; Disordered

Protein Families

Protein kinase superfamily
Tyr protein kinase family
EGF receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variant

Antibody

CAB025331 HPA045396 HPA070524

Interaction Protein

ENSG00000094631ENSG00000105647ENSG00000117461ENSG00000121879ENSG00000138032ENSG00000141736ENSG00000141738ENSG00000145675ENSG00000146648ENSG00000160691ENSG00000174791ENSG00000177885ENSG00000179295ENSG00000183386ENSG00000197747

Interaction Count

15

Interaction Dataset

intact_biogrid

Protein symbol ERBB3	UniProt ID P21860	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesDisease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters