Protein detail
DRD4
D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor)
Protein symbol DRD4 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 7 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor)
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
30..50; Helical; Name=1; 72..92; Helical; Name=2; 111..131; Helical; Name=3; 153..173; Helical; Name=4; 193..213; Helical; Name=5; 347..367; Helical; Name=6; 383..403; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificDistal convoluted tubule cells
Function & Pathway
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
- GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go
- GO:0004952 dopamine neurotransmitter receptor activity
- GO:0004993 G protein-coupled serotonin receptor activity
- GO:0005515 protein binding
- GO:0015459 potassium channel regulator activity
- GO:0017124 SH3 domain binding
- GO:0030594 neurotransmitter receptor activity
- GO:0035240 dopamine binding
- GO:0042802 identical protein binding
- GO:0046872 metal ion binding
- GO:0051378 serotonin binding
- GO:0051379 epinephrine binding
- GO:0051380 norepinephrine binding
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
45 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| 7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| dopamine_7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| rhodopsin | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | Surfaceome | No | Yes | No | Yes | No |
| class_a_rhodopsin | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_aminergic | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_aminergic_dopamine | receptor | GPCRdb | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| DRD4 | P21917 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| DRD4 | P21917 | GNAO | P09471 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| DRD4 | P21917 | GNAI1 | P63096 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| DRD4 | P21917 | GNAZ | P19086 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| DRD4 | P21917 | GNB5 | O14775 | Yes | Yes | No | SIGNOR | SIGNOR:21303898 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
419
Mass
43,901
Sequence
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
3D Structural Models
Turn
97..99; 201..203
Helix
35..61; 63..65; 68..86; 88..96; 105..138; 151..171; 190..200; 204..220; 340..344; 347..371; 379..403; 405..412
Beta Strand
144..147
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
238..254; Pro residues
Repeat
249..264; 1; approximate; 265..280; 2; 281..296; 3; 297..312; 4; approximate
Region
230..264; Disordered; 249..312; 4 X 16 AA approximate tandem repeats of [PA]-A-P-G-L-P-[PQR]-[DG]-P-C-G-P-D-C-A-P; 317..336; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Drugs
APOMORPHINETHIETHYLPERAZINEVEBRELTINIBNULLOLANZAPINEDEXPRAMIPEXOLEROPINIROLEELZOVANTINIBSITRAVATINIBSGX-523PRAMIPEXOLECHLORPROMAZINESARIZOTAN HYDROCHLORIDEROTIGOTINECLOTHIAPINETHIORIDAZINETIVANTINIBMK-2461SAVOLITINIBPERGOLIDE MESYLATEAMOXAPINELOXAPINELOXAPINE SUCCINATECOMPOUND 1O [PMID: 24210504]BMS-777607CABOZANTINIB S-MALATEOLANZAPINE PAMOATEGLESATINIBGOLVATINIBCAPMATINIBCOMPOUND 19A [PMID: 30503936]MERESTINIBCOMPOUND R-16 [PMID: 21967808]FORETINIBBROMOCRIPTINE MESYLATECOMPOUND 27 [PMID: 21123062]COMPOUND 8I [PMID: 22765894]AM7COMPOUND 16 [PMID: 18945615]METHOTRIMEPRAZINEHALOPERIDOL DECANOATEPAMUFETINIBCLOZAPINELOXAPINE HYDROCHLORIDEALTIRATINIBEMIBETUZUMABNINGETINIBPRAMIPEXOLE DIHYDROCHLORIDEPROMAZINE HYDROCHLORIDEDROPERIDOLD6808GE-137ONARTUZUMABCRIZOTINIBDALMELITINIBPROMAZINETEPOTINIBHALOPERIDOL LACTATEENSARTINIBZICRONAPINEAMIVANTAMABAMG-337GUMARONTINIBPHA-665752ASENAPINEETILEVODOPAALECTINIBZIPRASIDONEPROPIOMAZINEZANZALINTINIBOMO-1TEREVALEFIMCHLORPROMAZINE HYDROCHLORIDEPARDOPRUNOXDEHYDRATED ALCOHOLLEVODOPATRIFLUOPERAZINE HYDROCHLORIDEERGOLOID MESYLATES, USPPIMOZIDEROPINIROLE HYDROCHLORIDEMELEVODOPAHEPATOCYTE GROWTH FACTORRIPK3 INHIBITOR 18NICOTINE POLACRILEXSU11274VABAMETKIB