Protein detail

DRD4

D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor)

Entry name DRD4	UniProt ID P21917	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor)

Protein Function (3)

Human disease related genes:Other diseases:Mental and behavioural disorders
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

30..50; Helical; Name=1; 72..92; Helical; Name=2; 111..131; Helical; Name=3; 153..173; Helical; Name=4; 193..213; Helical; Name=5; 347..367; Helical; Name=6; 383..403; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000069696

Entrez Gene Symbol

DRD4

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificDistal convoluted tubule cells

Function & Pathway7

Protein Function (3)

Human disease related genes:Other diseases:Mental and behavioural disorders
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (6)

Molecular Function (13)

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Biological Process (3)

KEGG (4)

Reactome (6)

Mediation Categories (4)

Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence52

Ligand-Receptor Signaling (45)

45 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No

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Regulatory Interaction Network (5)

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
DRD4	P21917	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
DRD4	P21917	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
DRD4	P21917	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:31160049
DRD4	P21917	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
DRD4	P21917	GNB5	O14775	Yes	Yes	No	SIGNOR	SIGNOR:21303898

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
DRD4-KLHL12-CUL3 complex	CUL3 DRD4 KLHL12	P21917 Q13618 Q53G59	0:0:0	CORUM	CORUM:6815	18303015

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains12

Sequences

Length

419

Mass

43,901

Sequence

MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC

3D Structural Models

Turn

97..99; 201..203

Helix

35..61; 63..65; 68..86; 88..96; 105..138; 151..171; 190..200; 204..220; 340..344; 347..371; 379..403; 405..412

Beta Strand

144..147

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

238..254; Pro residues

Repeat

249..264; 1; approximate; 265..280; 2; 281..296; 3; 297..312; 4; approximate

Region

230..264; Disordered; 249..312; 4 X 16 AA approximate tandem repeats of [PA]-A-P-G-L-P-[PQR]-[DG]-P-C-G-P-D-C-A-P; 317..336; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance1

Drugs (86)

APOMORPHINE THIETHYLPERAZINE VEBRELTINIB NULL OLANZAPINE DEXPRAMIPEXOLE ROPINIROLE ELZOVANTINIB SITRAVATINIB SGX-523 PRAMIPEXOLE CHLORPROMAZINE SARIZOTAN HYDROCHLORIDE ROTIGOTINE CLOTHIAPINE THIORIDAZINE TIVANTINIB MK-2461 SAVOLITINIB PERGOLIDE MESYLATE AMOXAPINE LOXAPINE LOXAPINE SUCCINATE COMPOUND 1O [PMID: 24210504]BMS-777607 CABOZANTINIB S-MALATE OLANZAPINE PAMOATE GLESATINIB GOLVATINIB CAPMATINIB COMPOUND 19A [PMID: 30503936]MERESTINIB COMPOUND R-16 [PMID: 21967808]FORETINIB BROMOCRIPTINE MESYLATE COMPOUND 27 [PMID: 21123062]COMPOUND 8I [PMID: 22765894]AM7 COMPOUND 16 [PMID: 18945615]METHOTRIMEPRAZINE HALOPERIDOL DECANOATE PAMUFETINIB CLOZAPINE LOXAPINE HYDROCHLORIDE ALTIRATINIB EMIBETUZUMAB NINGETINIB PRAMIPEXOLE DIHYDROCHLORIDE PROMAZINE HYDROCHLORIDE DROPERIDOL D6808 GE-137 ONARTUZUMAB CRIZOTINIB DALMELITINIB PROMAZINE TEPOTINIB HALOPERIDOL LACTATE ENSARTINIB ZICRONAPINE AMIVANTAMAB AMG-337 GUMARONTINIB PHA-665752 ASENAPINE ETILEVODOPA ALECTINIB ZIPRASIDONE PROPIOMAZINE ZANZALINTINIB OMO-1 TEREVALEFIM CHLORPROMAZINE HYDROCHLORIDE PARDOPRUNOX DEHYDRATED ALCOHOL LEVODOPA TRIFLUOPERAZINE HYDROCHLORIDE ERGOLOID MESYLATES, USP PIMOZIDE ROPINIROLE HYDROCHLORIDE MELEVODOPA HEPATOCYTE GROWTH FACTOR RIPK3 INHIBITOR 18 NICOTINE POLACRILEX SU11274 VABAMETKIB

Supporting Publications2

PMID	Title	Abstract
32560723	T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.	No abstract available
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No abstract available