Protein detail
CADH3
Cadherin-3 (Placental cadherin) (P-cadherin)
Protein symbol CADH3 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Cadherin-3 (Placental cadherin) (P-cadherin)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Transmembrane
655..677; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CDHPPCAD
Gene Description
Cadherin 3
Chromosome
16
Position
68636189-68727468
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineCell SpecificColonocytesSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CTND1 | O60716 | CADH3 | P22223 | Yes | Yes | No | InnateDBHPRDSIGNORBioGRID | InnateDB:8660921HPRD:8660921BioGRID:8660921SIGNOR:14610055 |
| CADH3 | P22223 | CTNB1 | P35222 | Yes | Yes | No | HPRDHINTSIGNOR | HPRD:12800191SIGNOR:21255999HPRD:8227214HPRD:11889072HPRD:10381631HINT:36950384HINT:33961781 |
| ARVC | O00192 | CADH3 | P22223 | Yes | Yes | No | SIGNOR | SIGNOR:14610055 |
| CTND2 | Q9UQB3 | CADH3 | P22223 | Yes | Yes | No | SIGNOR | SIGNOR:14610055 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
829
Mass
91,418
Sequence
MGLPRGPLASLLLLQVCWLQCAASEPCRAVFREAEVTLEAGGAEQEPGQALGKVFMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIFPSKRILRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVETCPGPWKGGFILPVLGAVLALLFLLLVLLLLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPTIIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGEDD
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P22223-1; Sequence=Displayed; Name=2; IsoId=P22223-2; Sequence=VSP_024820
Alternative Sequence
761..829; NLKAANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGEDD -> GRGERGSQRGNGGLQLARGRTRRS (in isoform 2)
3D Structural Models
Turn
149..151; 162..164; 175..177; 274..276; 288..290
Helix
134..137; 303..305
Beta Strand
108..110; 114..117; 124..130; 141..148; 152..154; 157..160; 166..169; 179..189; 194..196; 199..206; 214..216; 218..225; 233..236; 246..249; 254..262; 265..267; 269..272; 278..281; 293..301; 309..319
3D Structure
X-ray crystallography (19)
Domain & Motif Annotations
Domain (CC)
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain (FT)
108..215; Cadherin 1; 216..328; Cadherin 2; 329..440; Cadherin 3; 441..546; Cadherin 4; 547..650; Cadherin 5
Clinical Relevance
Disease Involvement
Disease variantEctodermal dysplasiaHypotrichosis
Related Diseases
Biomarker
Phase 1