Protein detail
ACES
Acetylcholinesterase (AChE) (EC 3.1.1.7)
Entry name ACES | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 2 | Transmembrane count | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Acetylcholinesterase (AChE) (EC 3.1.1.7)
Protein Function (5)
- Predicted intracellular proteins
- Blood group antigen proteins
- Enzymes
- ENZYME proteins:Hydrolases
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificintestineCell SpecificColonocytes
Function & Pathway
Protein Function (5)
- Predicted intracellular proteins
- Blood group antigen proteins
- Enzymes
- ENZYME proteins:Hydrolases
- FDA approved drug targets:Small molecule drugs
Cellular Component (13)
- GO:0005576 extracellular region
- GO:0005604 basement membrane
- GO:0005615 extracellular space
- GO:0005634 nucleus
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0031594 neuromuscular junction
- GO:0043083 synaptic cleft
Page 1 of 2
Molecular Function (10)
- GO:0001540 amyloid-beta binding
- GO:0003990 acetylcholinesterase activity
- GO:0004104 cholinesterase activity
- GO:0005515 protein binding
- GO:0005518 collagen binding
- GO:0016787 hydrolase activity
- GO:0017171 serine hydrolase activity
- GO:0042166 acetylcholine binding
- GO:0042803 protein homodimerization activity
- GO:0043236 laminin binding
KEGG (3)
Reactome (9)
- R-hsa-1483206 glycerophospholipid biosynthesis
- R-hsa-556833 metabolism of lipids
- R-hsa-112316 neuronal system
- R-hsa-112311 neurotransmitter clearance
- R-hsa-2980736 peptide hormone metabolism
- R-hsa-1483257 phospholipid metabolism
- R-hsa-1483191 synthesis of pc
- R-hsa-422085 synthesis secretion and deacylation of ghrelin
- R-hsa-112315 transmission across chemical synapses
Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence21
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | Yes | Yes | ||
| extracellular | extracellular | LOCATE | Yes | Yes | |||
| extracellular | extracellular | OmniPath | Yes | Yes | |||
| intracellular | intracellular | LOCATE | Yes | Yes | |||
| intracellular | intracellular | ComPPI | Yes | Yes | |||
| intracellular | intracellular | GO_Intercell | Yes | Yes | |||
| intracellular | intracellular | UniProt_location | Yes | Yes | |||
| intracellular | intracellular | OmniPath | Yes | Yes | |||
| plasma_membrane | plasma_membrane | UniProt_location | Yes | Yes | |||
| plasma_membrane | plasma_membrane | OmniPath | Yes | Yes |
Page 1 of 2Next
Protein Complex Composition (2)
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ACHECOX4I1H4C4MCM5RPL14 | P13073P22303P33992P50914P62805 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9744 | ||
| ACHE | P22303 | 2 | PDB | PDB:7xn1PDB:7p1pPDB:8aenPDB:5hf8PDB:8dt5PDB:6zwePDB:6o50PDB:8dt4PDB:7e3hPDB:6o66PDB:6o5sPDB:7d9pPDB:6cqxPDB:6wvoPDB:6f25PDB:6wvcPDB:7d9oPDB:5hf6PDB:5hq3PDB:4ey4PDB:6cqzPDB:6wvqPDB:6u37PDB:8dt7PDB:6wvpPDB:6wuyPDB:6o5vPDB:7e3dPDB:6cqyPDB:6o52PDB:4m0ePDB:6ntoPDB:5hfaPDB:6o5rPDB:6wv1PDB:3liiPDB:6nthPDB:6ntkPDB:6ntmPDB:6o4wPDB:9omtPDB:5hf5PDB:6o4xPDB:7rb7PDB:6ntlPDB:8aevPDB:6ntnPDB:6cquPDB:6u34PDB:8dt2PDB:4ey6PDB:6cqtPDB:6wuzPDB:6cqvPDB:5hf9PDB:7rb6PDB:6wuvPDB:6cqwPDB:4m0fPDB:5fpqPDB:4ey7PDB:9omsPDB:6u3pPDB:6ntgPDB:6neaPDB:7p1nPDB:4ey5PDB:7d9q |
Sequence, Structure & Domains
Sequences
Length
614
Mass
67,796
Sequence
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=T; Synonyms=ACHE-S, synaptic; IsoId=P22303-1; Sequence=Displayed; Name=H; Synonyms=ACHE-E, erythrocytic, E4-E5; IsoId=P22303-2; Sequence=VSP_001457; Name=R; Synonyms=ACHE-R, readthrough; IsoId=P22303-4; Sequence=VSP_035569, VSP_035570; Name=4; IsoId=P22303-3; Sequence=VSP_035568
Alternative Sequence
357..444; Missing (in isoform 4); 575..614; DTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL -> ASEAPSTCPGFTHGEAAPRPGLPLPLLLLHQLLLLFLSHLRRL (in isoform H); 575..603; DTLDEAERQWKAEFHRWSSYMVHWKNQFD -> GMQGPAGSAGRRGVGARQCNPSLLPLASE (in isoform R); 604..614; Missing (in isoform R)
3D Structural Models
Turn
153..155; 266..268; 286..290; 371..373; 478..481; 536..538
Helix
37..39; 74..76; 112..115; 162..164; 167..173; 185..189; 202..217; 218..221; 235..244; 247..250; 272..285; 297..306; 309..315; 316..319; 343..349; 367..370; 387..397; 403..413; 422..437; 439..451; 472..474; 482..485; 488..490; 498..517; 557..564; 567..572; 580..601
Beta Strand
40..43; 46..49; 51..53; 60..67; 88..92; 99..101; 123..125; 129..137; 143..149; 176..180; 196..198; 223..233; 254..260; 292..294; 320..322; 325..327; 333..341; 356..362; 364..366; 379..381; 418..420; 455..461; 491..494; 526..528; 540..547; 550..553
3D Structure
X-ray crystallography (78)
Domain & Motif Annotations
Protein Families
Type-B carboxylesterase/lipase family
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.
Clinical Relevance
Related Diseases (16)
Alzheimer diseaseDementiaGlaucomaLips/oral mucosa miscellaneous disorderMild neurocognitive disorderMyasthenia gravisNeurodegenerative disorderOesophageal/gastroduodenal disorderPainParasitic worm infestationParkinsonismPediculosisSolid tumour/cancerSubstance abuseUnspecific substance harmful effectUrinary system disease
Biomarker
Approved; Phase 1/2; Discontinued in Phase 2; Phase 3; Investigative; Phase 1
Drugs (71)
GALANTAMINENULLPHYSOSTIGMINE SALICYLATEPRALIDOXIME CATIONDONEPEZILHUPERZINE ADEMECARIUM BROMIDEEDROPHONIUM CATION&BETA-CGRPACOTIAMIDE HYDROCHLORIDEITOPRIDEAMBENONIUMAMYLINAC187KBP-066DESOXYCORDIFOLINEEDROPHONIUM CHLORIDESALMON CALCITONINMINAPRINETURBINATINEACOTIAMIDEECHOTHIOPHATE IODIDERIVASTIGMINEMALATHIONLADOSTIGILPROPANIDIDTACRINEPHENSERINEEPTASTIGMINEMINAPRINE HYDROCHLORIDETACRINE HYDROCHLORIDEPHYSOSTIGMINEAMBENONIUM CHLORIDERADIOSENSITIZING AGENTSURONACRINE MALEATELATREPIRDINENEOSTIGMINERIVASTIGMINE TARTRATEMAGNESIUM CHLORIDE ANHYDROUSTHIOGUANINEHUMAN CALCITONINMIMOPEZILSKIMMIANINEBUNTANETAPDAVALINTIDE[125I]CT (HUMAN)DISTIGMINEGALACTITOLPRAMLINTIDEMETHADONE HYDROCHLORIDEHEXAFLUORENIUM BROMIDE8-AZAGUANINEDONEPEZIL HYDROCHLORIDEISOFLUROPHATEADRENOMEDULLIN 2/INTERMEDINCT-(8-32) (SALMON)PYRIDOSTIGMINEADRENOMEDULLIN[125I]CT (SALMON)BETAMETHASONEAMLINTIDEPYRIDOSTIGMINE BROMIDEKBP-088&ALPHA-CGRPPRALIDOXIME CHLORIDEECHOTHIOPHATEAMOCARZINE6-AMINONICOTINAMIDEMETHANESULFONYL FLUORIDE
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No related sentences available |