Protein detail
ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Membrane component chromosome 6 surface marker 1) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]
Protein symbol ENPP1 | UniProt ID | EVMP score 0.25 |
Frequency | Transmembrane count 1 | Protein classification CD markersDisease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsPredicted secreted proteins |
Basic Information
Protein Names
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Membrane component chromosome 6 surface marker 1) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]
Protein Class
CD markersDisease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Human disease related genes:Endocrine and metabolic diseases:Diabetes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
- CD markers
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Potential drug targets
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- Enzymes
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
- Disease related genes
Transmembrane
77..97; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
M6S1NPPSPC-1PCA1PDNP1
Gene Description
Ectonucleotide pyrophosphatase/phosphodiesterase 1
Chromosome
6
Position
131808016-131895155
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAdrenal medulla cellsSecretome LocationSecreted - unknown locationSecretome FunctionReceptor
Function & Pathway
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Human disease related genes:Endocrine and metabolic diseases:Diabetes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
- CD markers
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Potential drug targets
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- Enzymes
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
- Disease related genes
Cellular Component
Molecular Function
- GO:0003676 nucleic acid binding
- GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
- GO:0004527 exonuclease activity
- GO:0004528 phosphodiesterase I activity
- GO:0004551 dinucleotide phosphatase activity
- GO:0005044 scavenger receptor activity
- GO:0005158 insulin receptor binding
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008270 zinc ion binding
- GO:0016791 phosphatase activity
- GO:0030247 polysaccharide binding
- GO:0036219 GTP diphosphatase activity
- GO:0036221 UTP diphosphatase activity
- GO:0042803 protein homodimerization activity
- GO:0047429 nucleoside triphosphate diphosphatase activity
- GO:0047693 ATP diphosphatase activity
- GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding
- GO:0106177 cyclic-GMP-AMP hydrolase activity
Biological Process
KEGG
- hsa00230 Purine metabolism
- KEGG:hsa00240 Pyrimidine metabolism
- KEGG:hsa00500 Starch and sucrose metabolism
- KEGG:hsa00740 Riboflavin metabolism
- KEGG:hsa00760 Nicotinate and nicotinamide metabolism
- KEGG:hsa00770 Pantothenate and CoA biosynthesis
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa01232 Nucleotide metabolism
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | Yes | Yes | No |
| receptor | receptor | OmniPath | No | Yes | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | LOCATE | No | No | Yes | Yes | No |
| intracellular | intracellular | ComPPI | No | No | Yes | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| inhibitory_cofactor | receptor_regulator | CellChatDB | Yes | No | Yes | Yes | No |
| receptor_regulator | receptor_regulator | OmniPath | Yes | No | Yes | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | Surfaceome | Yes | No | Yes | Yes | No |
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Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ENPP1 | P22413 | INSR | P06213 | Yes | No | Yes | SIGNORHPRDHINTWangCellChatDB-cofactors | HPRD:10615944SIGNOR:10615944HINT:11289049HINT:10615944 |
| HS71B | P0DMV9 | ENPP1 | P22413 | Yes | Yes | No | SIGNOR | SIGNOR:19083193 |
| HS71A | P0DMV8 | ENPP1 | P22413 | Yes | Yes | No | SIGNOR | SIGNOR:19083193 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
925
Mass
104,924
Sequence
MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED
3D Structural Models
Turn
151..155; 282..285; 323..326; 413..415; 462..468; 478..480; 588..591; 685..688; 865..868
Helix
168..173; 180..183; 190..192; 222..227; 228..231; 233..240; 256..265; 269..272; 293..296; 298..300; 306..312; 346..357; 376..382; 387..409; 438..441; 471..477; 542..544; 566..568; 569..576; 592..594; 638..641; 646..656; 722..724; 726..729; 755..757; 769..788; 810..815; 845..847; 874..884; 889..896; 908..915
Beta Strand
163..165; 212..217; 242..246; 276..281; 286..288; 290..292; 366..372; 384..386; 417..421; 446..450; 456..461; 486..491; 509..514; 520..523; 530..534; 548..552; 595..597; 671..675; 677..684; 689..697; 736..738; 745..751; 763..765; 791..798; 804..806; 818..820; 823..825; 829..840; 849..859
3D Structure
Electron microscopy (1); NMR spectroscopy (1); X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
1..17; Gly residues
Motif
45..52; Di-leucine motif
Domain (CC)
The di-leucine motif is required for basolateral targeting in epithelial cells, and for targeting to matrix vesicles derived from mineralizing cells.; DOMAIN: The nuclease-like domain is most probably catalytically inactive as residues that are essential for catalysis in the DNA/RNA non-specific endonucleases are not conserved. However, it is required for the stability of the protein and the catalytic activity born by the phosphodiesterase domain.
Domain (FT)
104..144; SMB 1; 145..189; SMB 2
Region
1..43; Disordered; 191..591; Phosphodiesterase; 597..647; Linker; 654..925; Nuclease-like domain
Protein Families
Nucleotide pyrophosphatase/phosphodiesterase family
Sequence Similarities
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
Clinical Relevance
Disease Involvement
Diabetes mellitusDisease variantObesity
Biomarker
Phase 1/2
Interaction Protein
ENSG00000171105
Interaction Count
1
Interaction Dataset
intact_biogrid