Protein detail

FGFR3

Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)

Entry name
FGFR3
UniProt ID
P22607
EVMP confidence score
0.47
Supporting publications (n)
11
Transmembrane count
1
Protein classification
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information13
Protein Names
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Protein Class (10)
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins
Protein Function (18)
  • Cancer-related genes:Mutational cancer driver genes
  • Predicted intracellular proteins
  • Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
  • ENZYME proteins:Transferases
  • Cancer-related genes:Mutated cancer genes
  • CD markers
  • RAS pathway related proteins
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
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Transmembrane
376..396; Helical
Transmembrane Count
1
Ensembl
ENSG00000068078
Entrez Gene Symbol
FGFR3
Gene Synonym (4)
ACHCD333CEK2JTK4
Gene Description
Fibroblast growth factor receptor 3
Chromosome
4
Position
1793293-1808872
Supporting publications (n)
11
EVMP confidence score
0.47
Fluorescence & Localization5
FGFR3 fluorescence
Cell SpecificAstrocytesSingle-Nuclei Brain SpecificpericyteBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells
Function & Pathway7
Protein Function (18)
  • Cancer-related genes:Mutational cancer driver genes
  • Predicted intracellular proteins
  • Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
  • ENZYME proteins:Transferases
  • Cancer-related genes:Mutated cancer genes
  • CD markers
  • RAS pathway related proteins
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
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Cellular Component (8)
Molecular Function (6)
Biological Process (3)
KEGG (13)
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Reactome (22)
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Mediation Categories (4)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence80

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
FGFR3FGFR1P11362Y599phosphorylationPhosphoSite
FGFR3IGF1RP08069Y647phosphorylationKEAKEA:17570479

Ligand-Receptor Signaling (63)

63 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorHGNCNoYesYesYesNo
receptorreceptorCellPhoneDBNoYesYesYesNo
receptorreceptorGO_IntercellNoYesYesYesNo
receptorreceptorHPMRNoYesYesYesNo
receptorreceptorICELLNETNoYesYesYesNo
receptorreceptorCellChatDBNoYesYesYesNo
receptorreceptorCellTalkDBNoYesYesYesNo
receptorreceptorSurfaceomeNoYesYesYesNo
receptorreceptorRamilowski2015NoYesYesYesNo
receptorreceptorLRdbNoYesYesYesNo
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Regulatory Interaction Network (10)

10 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
FGF9P31371FGFR3P22607YesYesNoiTALKICELLNETHINTSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdbCellinker:25772309connectomeDB2020:15231666connectomeDB2020:8576175HPRD:8576175SignaLink3:8576175ICELLNET:25772309SignaLink3:10574949HPRD:10574949Cellinker:8576175CellTalkDB:16597617Cellinker:15231666HINT:8576175SignaLink3:23331499connectomeDB2020:10574949Cellinker:10574949HINT:10574949Cellinker:16597617SignaLink3:8663044LRdb:16597617
FGFR3P22607LGULQ04760YesYesNoSIGNORSIGNOR:34838714
FGFR3P22607CILK1Q9UPZ9YesNoYesSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:30782830SIGNOR:30782830PhosphoSite:30782830
FGFR3P22607TET2Q6N021YesNoYesSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperPhosphoSite:33097695ProtMapper:33097695SIGNOR:33097695
FGFR3P22607M3K7O43318YesYesNoSIGNORSIGNOR:24466111
FGFR3P22607STAT3P40763YesYesNophosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperHPRD-phosHPRD-phos:12244095HPRD:10918587KEA:8272872HPRD-phos:12626508KEA:12626508KEA:9582023ProtMapper:11350938HPRD-phos:10918587KEA:11940572KEA:9083098HPRD:14551213HPRD:12244095KEA:11850821KEA:12244095ProtMapper:17016520KEA:9305919ProtMapper:10918587ProtMapper:11294897KEA:10918587HPRD-phos:11350938ProtMapper:12244095ProtMapper:17389395HPRD:11940572HPRD:12626508ProtMapper:29030113HPRD:12576423HPRD-phos:12576423KEA:8626374ProtMapper:14551213KEA:15592455SIGNOR:10918587KEA:11350938HPRD:11350938HPRD-phos:19901323HPRD-phos:11294897HPRD-phos:14551213KEA:9566874HPRD-phos:17389395KEA:11294897ProtMapper:16497976KEA:14551213ProtMapper:19901323HPRD-phos:8626374HPRD-phos:16497976HPRD:8626374ProtMapper:11940572HPRD:11294897ProtMapper:12626508ProtMapper:8626374ProtMapper:12576423HPRD-phos:11940572KEA:11429593HPRD-phos:17016520KEA:12576423
FGF2P09038FGFR3P22607YesYesNoiTALKICELLNETSIGNORDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdbCellTalkDB:16597617Cellinker:25772309SIGNOR:15780951SIGNOR:22298955LRdb:16597617ICELLNET:25772309Cellinker:10574949HPRD:10574949HPMR:8663044connectomeDB2020:10574949DIP:9045692Cellinker:8663044connectomeDB2020:8663044
FGFR3P22607STAT1P42224YesYesNoHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperACSNHPRD-phosHPRD-phos:7690989HPRD:10918587ProtMapper:19088846HPRD-phos:7657660ProtMapper:15322115KEA:10748192HPRD:15322115HPRD:7657660ACSN:16488589ProtMapper:12817007ProtMapper:7657660KEA:15322115HPRD-phos:10918587KEA:12637327ACSN:17496910HPRD-phos:11839738ProtMapper:7690989ACSN:15567848ACSN:15199124KEA:11839738HPRD:7543024KEA:11438544HPRD:7690989KEA:7592750KEA:12817007HPRD-phos:7543024HPRD:12637327ProtMapper:10918587ACSN:14585353ACSN:12040186KEA:10918587ProtMapper:11294897ACSN:19615955ACSN:11447289KEA:11152457HPRD:12817007HPRD-phos:15322115HPRD-phos:12817007HPRD:11839738KEA:7690989ProtMapper:29030113ACSN:15173823ProtMapper:11839738ProtMapper:12637327SIGNOR:10918587KEA:10982844HPRD-phos:12637327HPRD-phos:11294897KEA:11294897KEA:9355737ACSN:19568798KEA:7657660ACSN:6321473HPRD:11294897KEA:7543024ACSN:11997436ProtMapper:7543024
FGF1P05230FGFR3P22607YesYesNoiTALKICELLNETSIGNORHINTDIPLit-BM-17CellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015CellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdbCellinker:25772309SPIKE_LC:17145710Cellinker:14732692HPRD:14732692HINT:22955284HINT:9045692Lit-BM-17:10574949ICELLNET:25772309HPRD:10574949Lit-BM-17:9045692connectomeDB2020:14732692HINT:14732692DIP:9045692Lit-BM-17:14732692CellTalkDB:16597617DIP:22244757HINT:22244757HINT:8576175Lit-BM-17:8576175connectomeDB2020:10574949SIGNOR:22298955Cellinker:10574949HINT:10574949SPIKE_LC:14732692LRdb:16597617
FGFR3P22607KS6A3P51812YesNoNoSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetProtMapperRLIMS-P_ProtMapperKinexus_KEAKEAREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:17785199PhosphoSite:25014166ProtMapper:19223461KEA:18156174ProtMapper:23936765ProtMapper:18156174

Protein Complex Composition (4)

4 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
FGF1FGFR3P05230P226071:1PDBPDB:1ry7
FGFR3P226072PDBPDB:2lzlPDB:8uduPDB:6pnxPDB:8udvPDB:9cd7PDB:8udt
B9D1B9D2FGFR3TMEM231P22607Q9BPU9Q9H6L2Q9UPM90:0:0:0hu.MAP
FGF23FGFR3KLP22607Q9GZV9Q9UEF72:1:1PDBPDB:7ysu

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMass Spectrometry138113368
Sequence, Structure & Domains15

Sequences

Length
806
Mass
87,710
Sequence
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=IIIc; IsoId=P22607-1; Sequence=Displayed; Name=2; Synonyms=IIIb; IsoId=P22607-2; Sequence=VSP_002988; Name=3; Synonyms=FGFR3deltaTM; IsoId=P22607-3; Sequence=VSP_002989; Name=4; IsoId=P22607-4; Sequence=VSP_040945
Alternative Sequence
311..422; Missing (in isoform 3); 311..358; TAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLP -> SWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRA (in isoform 2); 654..806; GRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT -> LVLWGPALGDLHAGGLPVPRHPCGGALQAAEGGPPHGQARQLHTRPVHDHAGVLACRALPEAHLQAAGGGPGPCPYRDVHRRVPGPVGAFRAVLPGWPGHPQLQLLRGRLRVCPRPAAPGPTQQWGLADVKGHWSPTM (in isoform 4)

3D Structural Models

Turn
208..211; 319..321; 643..645
Helix
156..158; 220..222; 293..295; 374..398; 463..465; 469..471; 516..532; 563..568; 591..610; 620..622; 658..660; 663..668; 673..688; 700..708; 721..730; 735..737; 741..756
Beta Strand
152..154; 163..167; 172..175; 185..187; 212..215; 226..232; 235..246; 263..268; 271..273; 283..289; 302..304; 324..326; 331..333; 335..345; 348..357; 369..372; 472..477; 480..492; 495..497; 502..508; 541..545; 547..550; 552..556; 571..573; 623..625; 631..633; 646..649; 653..655
3D Structure
Electron microscopy (1); NMR spectroscopy (1); X-ray crystallography (11)

Domain & Motif Annotations

Compositional Bias
132..145; Acidic residues; 771..787; Low complexity
Domain (CC)
The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans.
Domain (FT)
24..126; Ig-like C2-type 1; 151..244; Ig-like C2-type 2; 253..355; Ig-like C2-type 3; 472..761; Protein kinase
Region
126..153; Disordered; 765..806; Disordered
Protein Families (3)
  • Protein kinase superfamily
  • Tyr protein kinase family
  • Fibroblast growth factor receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Clinical Relevance9
Disease Involvement (8)
Cancer-related genesCraniosynostosisDeafnessDisease variantDwarfismEctodermal dysplasiaFDA approved drug targetsLacrimo-auriculo-dento-digital syndrome
Related Diseases (14)
Alzheimer diseaseBladder cancerBreast cancerCoronary atherosclerosisEndometrial cancerLiver cancerMultiple myelomaMyeloproliferative neoplasmMyocardial infarctionRenal cell carcinomaRetina cancerSkeletal anomalySolid tumour/cancerUreteral cancer
Biomarker
Phase 1/2; Phase 2; Phase 4; Approved; Phase 1; Phase 3; Terminated
Drug Targets
FDA approved drug targets
Drugs (95)
NINTEDANIB ESYLATENULLXL-999PD173074LINIFANIBGEFITINIBDACTOLISIBINFIGRATINIBMK-2461FUTIBATINIBCETRELIMABHMPL-453PALIFERMINDERAZANTINIBVOFATAMABTYROSINE KINASE INHIBITOR SU5402DOCETAXEL ANHYDROUSCEDIRANIBINFIGRATINIB PHOSPHATE3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONENIVOLUMABXL228FGFR INHIBITOR CPL304110ALISERTIBLY2874455PAZOPANIBBRIVANIBFEXAGRATINIBERDAFITINIBALPELISIBCISPLATINNVP-TAE684BORTEZOMIBPICTILISIBTRAPIDILTASURGRATINIBSORAFENIBIRINOTECAN HYDROCHLORIDEENMD-2076MLN-8054RABEPRAZOLEMASITINIBZOLIGRATINIBBRIVANIB ALANINATEENMD-981693U0126AZD-4547CP-547632ROGARATINIBDOVITINIBPONATINIBVARGATEFPD98059ASP5878SP-600125AEE-788DASATINIB ANHYDROUSSSR128129EPF-562271MIDOSTAURINERLOTINIBPEMIGATINIBILORASERTIBFGFR3 INHIBITOR TYRA-300PRN1371SINTILIMABRG-7444ENTRECTINIBFP-1039TRAFERMINDOVITINIB LACTATERG-1530IPATASERTIBAVUTOMETINIBANLOTINIBGUNAGRATINIBHESPERADINREGORAFENIBFGFR/CSF-1R INHIBITOR 3D185LY-2874455MEK INHIBITOR RO4987655ATEZOLIZUMABTAMATINIBCENISERTIBGEMCITABINECHEMBL:CHEMBL578061SELUMETINIBPI3K/BET INHIBITOR LY294002CP-459632ORANTINIBFGFR INHIBITOR DEBIO 1347S-49076TOZASERTIBCYC-116QUISINOSTAT
Antibody (2)
CAB004231HPA067204
Interaction Protein (4)
ENSG00000096384ENSG00000104824ENSG00000105401ENSG00000113578
Interaction Count
4
Interaction Dataset
intact_biogrid
Supporting Publications11
PMIDTitleAbstract
22106071Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT).No abstract available
24505114Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform.These included proteins of known association with cancer exosomes such as MFG-E8, integrins, and MET, and also those less widely reported as exosomally associated, such as ROR1 and ITIH4.
26884841Exosomes mediated pentose phosphate pathway in ovarian cancer metastasis: a proteomics analysis.No abstract available
28242843Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line.No abstract available
31320591Exosomes regulate neurogenesis and circuit assembly.No abstract available
31508500Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping.No abstract available
31588238Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment.No abstract available
34889606Surface Nanosieving Polyether Sulfone Particles with Graphene Oxide Encapsulation for the Negative Isolation toward Extracellular Vesicles.No abstract available
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No abstract available
40784529Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.No abstract available
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