Protein detail

FGFR3

Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)

Entry name FGFR3	UniProt ID P22607	EVMP score 0.47
Frequency 11	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)

Protein Class

Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteins

Protein Function

Cancer-related genes:Mutational cancer driver genes
Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
CD markers
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Human disease related genes:Cancers:Cancers of the urinary system
Human disease related genes:Congenital malformations:Congenital malformations of skin
Human disease related genes:Congenital malformations:Other congenital malformations
Kinases:Tyr protein kinases
Disease related genes
Human disease related genes:Cancers:Cancers of male genital organs
Predicted secreted proteins
FDA approved drug targets:Small molecule drugs

Transmembrane

376..396; Helical

Transmembrane Count

Ensembl

ENSG00000068078

Entrez Gene Symbol

FGFR3

Gene Synonym

ACHCD333CEK2JTK4

Gene Description

Fibroblast growth factor receptor 3

Chromosome

Position

1793293-1808872

Frequency

EVMP Score

0.47

Fluorescence & Localization

Cell SpecificAstrocytesSingle-Nuclei Brain SpecificpericyteBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells

Function & Pathway

Protein Function

Cancer-related genes:Mutational cancer driver genes
Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
CD markers
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Human disease related genes:Cancers:Cancers of the urinary system
Human disease related genes:Congenital malformations:Congenital malformations of skin
Human disease related genes:Congenital malformations:Other congenital malformations
Kinases:Tyr protein kinases
Disease related genes
Human disease related genes:Cancers:Cancers of male genital organs
Predicted secreted proteins
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
FGFR3	FGFR1	P11362	Y	599	phosphorylation	PhosphoSite
FGFR3	IGF1R	P08069	Y	647	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

63 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	Yes	Yes	No
secreted	secreted	UniProt_keyword	No	No	Yes	Yes	No
secreted	secreted	OmniPath	No	No	Yes	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	Yes	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	Yes	Yes	No
cell_surface	cell_surface	OmniPath	No	No	Yes	Yes	No

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Regulatory Interaction Network

10 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FGF9	P31371	FGFR3	P22607	Yes	Yes	No	iTALKICELLNETHINTSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:25772309 connectomeDB2020:15231666 connectomeDB2020:8576175 HPRD:8576175 SignaLink3:8576175 ICELLNET:25772309 SignaLink3:10574949 HPRD:10574949 Cellinker:8576175 CellTalkDB:16597617 Cellinker:15231666 HINT:8576175 SignaLink3:23331499 connectomeDB2020:10574949 Cellinker:10574949 HINT:10574949 Cellinker:16597617 SignaLink3:8663044 LRdb:16597617
FGFR3	P22607	LGUL	Q04760	Yes	Yes	No	SIGNOR	SIGNOR:34838714
FGFR3	P22607	CILK1	Q9UPZ9	Yes	No	Yes	SIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:30782830 SIGNOR:30782830 PhosphoSite:30782830
FGFR3	P22607	TET2	Q6N021	Yes	No	Yes	SIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:33097695 ProtMapper:33097695 SIGNOR:33097695
FGFR3	P22607	M3K7	O43318	Yes	Yes	No	SIGNOR	SIGNOR:24466111
FGFR3	P22607	STAT3	P40763	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperHPRD-phos	HPRD-phos:12244095 HPRD:10918587 KEA:8272872 HPRD-phos:12626508 KEA:12626508 KEA:9582023 ProtMapper:11350938 HPRD-phos:10918587 KEA:11940572 KEA:9083098 HPRD:14551213 HPRD:12244095 KEA:11850821 KEA:12244095 ProtMapper:17016520 KEA:9305919 ProtMapper:10918587 ProtMapper:11294897 KEA:10918587 HPRD-phos:11350938 ProtMapper:12244095 ProtMapper:17389395 HPRD:11940572 HPRD:12626508 ProtMapper:29030113 HPRD:12576423 HPRD-phos:12576423 KEA:8626374 ProtMapper:14551213 KEA:15592455 SIGNOR:10918587 KEA:11350938 HPRD:11350938 HPRD-phos:19901323 HPRD-phos:11294897 HPRD-phos:14551213 KEA:9566874 HPRD-phos:17389395 KEA:11294897 ProtMapper:16497976 KEA:14551213 ProtMapper:19901323 HPRD-phos:8626374 HPRD-phos:16497976 HPRD:8626374 ProtMapper:11940572 HPRD:11294897 ProtMapper:12626508 ProtMapper:8626374 ProtMapper:12576423 HPRD-phos:11940572 KEA:11429593 HPRD-phos:17016520 KEA:12576423
FGF2	P09038	FGFR3	P22607	Yes	Yes	No	iTALKICELLNETSIGNORDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	CellTalkDB:16597617 Cellinker:25772309 SIGNOR:15780951 SIGNOR:22298955 LRdb:16597617 ICELLNET:25772309 Cellinker:10574949 HPRD:10574949 HPMR:8663044 connectomeDB2020:10574949 DIP:9045692 Cellinker:8663044 connectomeDB2020:8663044
FGFR3	P22607	STAT1	P42224	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperACSNHPRD-phos	HPRD-phos:7690989 HPRD:10918587 ProtMapper:19088846 HPRD-phos:7657660 ProtMapper:15322115 KEA:10748192 HPRD:15322115 HPRD:7657660 ACSN:16488589 ProtMapper:12817007 ProtMapper:7657660 KEA:15322115 HPRD-phos:10918587 KEA:12637327 ACSN:17496910 HPRD-phos:11839738 ProtMapper:7690989 ACSN:15567848 ACSN:15199124 KEA:11839738 HPRD:7543024 KEA:11438544 HPRD:7690989 KEA:7592750 KEA:12817007 HPRD-phos:7543024 HPRD:12637327 ProtMapper:10918587 ACSN:14585353 ACSN:12040186 KEA:10918587 ProtMapper:11294897 ACSN:19615955 ACSN:11447289 KEA:11152457 HPRD:12817007 HPRD-phos:15322115 HPRD-phos:12817007 HPRD:11839738 KEA:7690989 ProtMapper:29030113 ACSN:15173823 ProtMapper:11839738 ProtMapper:12637327 SIGNOR:10918587 KEA:10982844 HPRD-phos:12637327 HPRD-phos:11294897 KEA:11294897 KEA:9355737 ACSN:19568798 KEA:7657660 ACSN:6321473 HPRD:11294897 KEA:7543024 ACSN:11997436 ProtMapper:7543024
FGF1	P05230	FGFR3	P22607	Yes	Yes	No	iTALKICELLNETSIGNORHINTDIPLit-BM-17CellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015CellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb	Cellinker:25772309 SPIKE_LC:17145710 Cellinker:14732692 HPRD:14732692 HINT:22955284 HINT:9045692 Lit-BM-17:10574949 ICELLNET:25772309 HPRD:10574949 Lit-BM-17:9045692 connectomeDB2020:14732692 HINT:14732692 DIP:9045692 Lit-BM-17:14732692 CellTalkDB:16597617 DIP:22244757 HINT:22244757 HINT:8576175 Lit-BM-17:8576175 connectomeDB2020:10574949 SIGNOR:22298955 Cellinker:10574949 HINT:10574949 SPIKE_LC:14732692 LRdb:16597617
FGFR3	P22607	KS6A3	P51812	Yes	No	No	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetProtMapperRLIMS-P_ProtMapperKinexus_KEAKEAREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:17785199 PhosphoSite:25014166 ProtMapper:19223461 KEA:18156174 ProtMapper:23936765 ProtMapper:18156174

Protein Complex Composition

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
FGF1 FGFR3	P05230 P22607	1:1	PDB	PDB:1ry7
FGFR3	P22607	2	PDB	PDB:2lzlPDB:8uduPDB:6pnxPDB:8udvPDB:9cd7PDB:8udt
B9D1 B9D2 FGFR3 TMEM231	P22607 Q9BPU9 Q9H6L2 Q9UPM9	0:0:0:0	hu.MAP
FGF23 FGFR3 KL	P22607 Q9GZV9 Q9UEF7	2:1:1	PDB	PDB:7ysu

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass Spectrometry	1	38113368

Sequence, Structure & Domains

Sequences

Length

806

Mass

87,710

Sequence

MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=IIIc; IsoId=P22607-1; Sequence=Displayed; Name=2; Synonyms=IIIb; IsoId=P22607-2; Sequence=VSP_002988; Name=3; Synonyms=FGFR3deltaTM; IsoId=P22607-3; Sequence=VSP_002989; Name=4; IsoId=P22607-4; Sequence=VSP_040945

Alternative Sequence

311..422; Missing (in isoform 3); 311..358; TAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLP -> SWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRA (in isoform 2); 654..806; GRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT -> LVLWGPALGDLHAGGLPVPRHPCGGALQAAEGGPPHGQARQLHTRPVHDHAGVLACRALPEAHLQAAGGGPGPCPYRDVHRRVPGPVGAFRAVLPGWPGHPQLQLLRGRLRVCPRPAAPGPTQQWGLADVKGHWSPTM (in isoform 4)

3D Structural Models

Turn

208..211; 319..321; 643..645

Helix

156..158; 220..222; 293..295; 374..398; 463..465; 469..471; 516..532; 563..568; 591..610; 620..622; 658..660; 663..668; 673..688; 700..708; 721..730; 735..737; 741..756

Beta Strand

152..154; 163..167; 172..175; 185..187; 212..215; 226..232; 235..246; 263..268; 271..273; 283..289; 302..304; 324..326; 331..333; 335..345; 348..357; 369..372; 472..477; 480..492; 495..497; 502..508; 541..545; 547..550; 552..556; 571..573; 623..625; 631..633; 646..649; 653..655

3D Structure

Electron microscopy (1); NMR spectroscopy (1); X-ray crystallography (11)

Domain & Motif Annotations

Compositional Bias

132..145; Acidic residues; 771..787; Low complexity

Domain (CC)

The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans.

Domain (FT)

24..126; Ig-like C2-type 1; 151..244; Ig-like C2-type 2; 253..355; Ig-like C2-type 3; 472..761; Protein kinase

Region

126..153; Disordered; 765..806; Disordered

Protein Families

Protein kinase superfamily
Tyr protein kinase family
Fibroblast growth factor receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesCraniosynostosisDeafnessDisease variantDwarfismEctodermal dysplasiaFDA approved drug targetsLacrimo-auriculo-dento-digital syndrome

Related Diseases

Alzheimer disease Bladder cancer Breast cancer Coronary atherosclerosis Endometrial cancer Liver cancer Multiple myeloma Myeloproliferative neoplasm Myocardial infarction Renal cell carcinoma Retina cancer Skeletal anomaly Solid tumour/cancer Ureteral cancer

Biomarker

Phase 1/2; Phase 2; Phase 4; Approved; Phase 1; Phase 3; Terminated

Drug Targets

FDA approved drug targets

Drugs

NINTEDANIB ESYLATE NULL XL-999 PD173074 LINIFANIB GEFITINIB DACTOLISIB INFIGRATINIB MK-2461 FUTIBATINIB CETRELIMAB HMPL-453 PALIFERMIN DERAZANTINIB VOFATAMAB TYROSINE KINASE INHIBITOR SU5402 DOCETAXEL ANHYDROUS CEDIRANIB INFIGRATINIB PHOSPHATE 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE NIVOLUMAB XL228 FGFR INHIBITOR CPL304110 ALISERTIB LY2874455 PAZOPANIB BRIVANIB FEXAGRATINIB ERDAFITINIB ALPELISIB CISPLATIN NVP-TAE684 BORTEZOMIB PICTILISIB TRAPIDIL TASURGRATINIB SORAFENIB IRINOTECAN HYDROCHLORIDE ENMD-2076 MLN-8054 RABEPRAZOLE MASITINIB ZOLIGRATINIB BRIVANIB ALANINATE ENMD-981693 U0126 AZD-4547 CP-547632 ROGARATINIB DOVITINIB PONATINIB VARGATEF PD98059 ASP5878 SP-600125 AEE-788 DASATINIB ANHYDROUS SSR128129E PF-562271 MIDOSTAURIN ERLOTINIB PEMIGATINIB ILORASERTIB FGFR3 INHIBITOR TYRA-300 PRN1371 SINTILIMAB RG-7444 ENTRECTINIB FP-1039 TRAFERMIN DOVITINIB LACTATE RG-1530 IPATASERTIB AVUTOMETINIB ANLOTINIB GUNAGRATINIB HESPERADIN REGORAFENIB FGFR/CSF-1R INHIBITOR 3D185 LY-2874455 MEK INHIBITOR RO4987655 ATEZOLIZUMAB TAMATINIB CENISERTIB GEMCITABINE CHEMBL:CHEMBL578061 SELUMETINIB PI3K/BET INHIBITOR LY294002 CP-459632 ORANTINIB FGFR INHIBITOR DEBIO 1347 S-49076 TOZASERTIB CYC-116 QUISINOSTAT

Antibody

CAB004231 HPA067204

Interaction Protein

ENSG00000096384ENSG00000104824ENSG00000105401ENSG00000113578

Interaction Count

Interaction Dataset

intact_biogrid