Protein detail
GTR5
Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)
Entry name GTR5 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 3 | Transmembrane count 12 | Protein classification Metabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)
Protein Class (5)
Metabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Transmembrane
19..39; Helical; Name=1; 69..91; Helical; Name=2; 99..119; Helical; Name=3; 127..149; Helical; Name=4; 162..182; Helical; Name=5; 193..213; Helical; Name=6; 278..298; Helical; Name=7; 314..334; Helical; Name=8; 343..363; Helical; Name=9; 372..394; Helical; Name=10; 413..433; Helical; Name=11; 440..460; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
GLUT5
Gene Description
Solute carrier family 2 member 5
Chromosome
1
Position
9035106-9088478
Supporting publications (n)
3
EVMP confidence score
0.50
Fluorescence & Localization1
Cell SpecificEsophageal apical cells
Function & Pathway7
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Cellular Component (5)
Molecular Function (4)
Biological Process (3)
Reactome (4)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence23
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains7
Sequences
Length
501
Mass
54,974
Sequence
MEQQDQSMKEGRLTLVLALATLIAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNKVSEVYPEKEELKELPPVTSEQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P22732-1; Sequence=Displayed; Name=2; IsoId=P22732-2; Sequence=VSP_042031
Alternative Sequence
192..501; WPILLGLTGVPAALQLLLLPFFPESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNKVSEVYPEKEELKELPPVTSEQ -> EFRTSREHPHPFTTTLGPLLVFQSHHHRTGLSADWSLLTGWMSLGGPSCPEPT (in isoform 2)
Domain & Motif Annotations
Protein Families (3)
- Major facilitator superfamily
- Sugar transporter (TC 2.A.1.1) family
- Glucose transporter subfamily
Sequence Similarities
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Clinical Relevance5
Drugs (2)
Interaction Protein
ENSG00000169379
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No abstract available |
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |