Protein detail
LSHR
Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R)
Entry name LSHR | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 7 | Protein classification Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R)
Protein Class
Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Endocrine and metabolic diseases:Gonadal diseases
- Predicted intracellular proteins
- Human disease related genes:Reproductive system diseases:Reproductive system diseases
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Transmembrane
364..385; Helical; Name=1; 396..416; Helical; Name=2; 440..462; Helical; Name=3; 483..505; Helical; Name=4; 526..549; Helical; Name=5; 571..594; Helical; Name=6; 606..627; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
HHGLCGRLGR2LHRULG5
Gene Description
Luteinizing hormone/choriogonadotropin receptor
Chromosome
2
Position
48686774-48755730
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Human disease related genes:Endocrine and metabolic diseases:Gonadal diseases
- Predicted intracellular proteins
- Human disease related genes:Reproductive system diseases:Reproductive system diseases
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M199 Pid p38 mk2 pathway
- M229 Pid p38 alpha beta downstream pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
60 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | Almen2009 | No | Yes | No | Yes | No |
| rhodopsin | receptor | Almen2009 | No | Yes | No | Yes | No |
| gpcr | receptor | UniProt_keyword | No | Yes | No | Yes | No |
| seven_transmembrane_7tm | receptor | HPMR | No | Yes | No | Yes | No |
| 7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| lgr_glycoprotein_hormones_relaxin_like_7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| rhodopsin | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | Surfaceome | No | Yes | No | Yes | No |
| class_a_rhodopsin | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_protein | receptor | GPCRdb | No | Yes | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| LSHB | P01229 | LSHR | P22888 | Yes | Yes | No | iTALKGuide2Pharma_LRdbSIGNORHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:3470775LRdb:12727981scConnect:1922095Cellinker:12727981LRdb:3470775HPRD:3470775connectomeDB2020:3470775SIGNOR:10446903connectomeDB2020:1922095Cellinker:1922095Guide2Pharma:1922095CellTalkDB:1922095LRdb:1922095scConnect:12727981Guide2Pharma:12727981connectomeDB2020:12727981 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
Sequence, Structure & Domains
Sequences
Length
699
Mass
78,643
Sequence
MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
Alternative Products
Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=Long; IsoId=P22888-1; Sequence=Displayed; Name=Short; IsoId=P22888-2; Sequence=VSP_001962
Alternative Sequence
227..289; Missing (in isoform Short)
3D Structural Models
Turn
66..71; 91..93; 166..171; 215..218; 422..424; 561..563; 624..626
Helix
242..244; 262..264; 276..282; 360..372; 375..385; 393..421; 426..434; 437..469; 480..497; 500..503; 522..553; 564..593; 601..611; 614..623; 628..641
Beta Strand
53..58; 77..82; 102..105; 127..133; 151..157; 172..175; 177..180; 193..203; 219..222; 225..228; 239..241; 246..249; 270..272; 343..345; 556..559
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Repeat
96..115; LRR 1; 124..145; LRR 2; 149..171; LRR 3; 175..196; LRR 4; 198..220; LRR 5; 223..244; LRR 6
Domain (FT)
27..66; LRRNT
Protein Families
- G-protein coupled receptor 1 family
- FSH/LSH/TSH subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Clinical Relevance
Disease Involvement
Disease variantFDA approved drug targets
Related Diseases
Biomarker
Approved; Terminated; Discontinued in Phase 3; Phase 1; Phase 2; Investigative
Drug Targets
FDA approved drug targets
Drugs