Protein detail

KELL

Kell blood group glycoprotein (EC 3.4.24.-) (CD antigen CD238)

Entry name
KELL
UniProt ID
P23276
EVMP confidence score
0.53
Supporting publications (n)
5
Transmembrane count
1
Protein classification
Basic Information
Protein Names
Kell blood group glycoprotein (EC 3.4.24.-) (CD antigen CD238)
Protein Function (6)
  • Predicted intracellular proteins
  • Blood group antigen proteins
  • Cancer-related genes:Mutated cancer genes
  • CD markers
  • Enzymes
  • Peptidases:Metallopeptidases
Transmembrane
48..67; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
ENSG00000197993
Entrez Gene Symbol
KEL
Supporting publications (n)
5
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificBasal prostatic cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificplasmacytoid DC
Function & Pathway
Protein Function (6)
  • Predicted intracellular proteins
  • Blood group antigen proteins
  • Cancer-related genes:Mutated cancer genes
  • CD markers
  • Enzymes
  • Peptidases:Metallopeptidases
Cellular Component (5)
Molecular Function (3)
Biological Process (3)
Reactome (4)
Mediation Categories (4)
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence28

Ligand-Receptor Signaling (26)

26 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
cell_surfacecell_surfaceconnectomeDB2020
cell_surfacecell_surfaceOmniPath
transmembranetransmembrane_predictedPhobius
transmembrane_phobiustransmembrane_predictedAlmen2009
transmembrane_sosuitransmembrane_predictedAlmen2009
transmembrane_tmhmmtransmembrane_predictedAlmen2009
Page 3 of 3Previous

Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
KELLP23276EDN3P14138YesYesHPRDSIGNORHPRD:10438732SIGNOR:10438732

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationR Sequencing138795909
Sequence, Structure & Domains

Sequences

Length
732
Mass
82,824
Sequence
MEGGDQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWAVARRVLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW

Domain & Motif Annotations

Domain (FT)
76..732; Peptidase M13
Region
1..37; Disordered; 684..703; Disordered
Protein Families
Peptidase M13 family
Sequence Similarities
Belongs to the peptidase M13 family.
Supporting Publications5
PMIDTitleRelated sentences
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No related sentences available
39001700Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles.No related sentences available
40840701Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma.No related sentences available
41068253Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.No related sentences available
41307968Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.No related sentences available